Tretinoin
Description
Tretinoin is a potent form of vitamin A that is applied topically to treat skin
conditions such as acne and photoaging. Its main mechanism of action involves regulating cell growth and differentiation by binding to specific nuclear receptors. For acne treatment, tretinoin helps prevent clogged pores by normalizing the keratinization process within hair follicles. It promotes the shedding of dead skin cells and possesses anti-inflammatory properties, which help reduce the redness and swelling associated with acne lesions. In addition to its effectiveness in treating acne, tretinoin plays a significant role in reversing the signs of photoaging, or sun damage. It stimulates collagen production, which helps minimize the appearance of fine lines and wrinkles. Tretinoin also improves skin texture and reduces hyperpigmentation, resulting in a more even and youthful complexion. To maximize the benefits of tretinoin while minimizing side effects, proper usage is essential. Users should avoid prolonged sun exposure after application and always wear sunscreen with at least SPF 15 when outdoors, as the medication can increase photosensitivity. Staying well-hydrated by drinking plenty of water is also recommended, as tretinoin can cause skin dryness. Additionally, it is important to avoid popping acne lesions, as this can spread bacteria and lead to increased scarring.
Uses
Contraindications
When should one not use Tretinoin
Side effects
Common side effects of this drug are:
- Dry skin
- Scaling or peeling of the skin
- Burning sensation on the skin
- Redness of the skin
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You should avoid using it on inflamed or sunburned skin, due to the possibility of severe irritation.
- You experience redness, dryness or severe irritation. The doctor may reduce the dose and frequency of Tretinoin application or may also discontinue the treatment for a short time.
- You should avoid being exposed to direct sunlight after applying Tretinoin to reduce the chances of photosensitization (which means skin damage due to UV or sunlight). Try to use a good sunscreen with at least SPF 15 and full clothes to avoid exposure....
- You have an allergy to fish proteins, as there are chances of developing severe itching or swollen red bumps on the skin.
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Since Tretinoin is to be used externally on the skin it is less likely to interact with other medicines.
- However, you should tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
- Especially, if you are already using topical medicated soaps, shampoos, cleansers or products with a high concentration of alcohol, as it can increase the irritation with Tretinoin.
- Caution is advised if you are also taking medicines that increase sensitivity to sunlight (photosensitizers) like thiazides (antihypertensives), tetracyclines, fluoroquinolones, sulfonamides (antibiotics to treat infection), phenothiazines to treat brain disorders, because of the risk of side effects associated with exposure to the sun....
Dosage
Overdose
Missed a Dose
Content Details
Dr. Mansi Savla
B. Pharm, PharmD
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: What is acne?
Q: Does Tretinoin remove acne scars?
Q: Can I use other acne products with Tretinoin?
Q: Is Tretinoin safe for long-term use?
Q: What if my skin becomes too dry or irritated?
References
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Medicines containing Tretinoin
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