Simvastatin

Molecule Description

Simvastatin belongs to a group of medicines referred to as Statins. It reduces

levels of bad cholesterol (Low-Density Lipoprotein, or LDL) and triglycerides in the blood while increasing the level of good cholesterol (High-Density Lipoprotein or HDL).

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Simvastatin

This medicine is used along with a proper diet to help lower bad cholesterol and fats (such as LDL and triglycerides) and raise good cholesterol in the blood.

Contraindications of Simvastatin

When should one not use Simvastatin

Allergic to the medicine
Metabolic syndrome (blood abnormalities associated with the development of heart diseases)
Muscle problems
Stroke caused by bleeding in the brain
Liver problems
Severe renal impairment
High blood sugar
Abnormal liver function tests
Chronic alcoholics
Hypersensitivity to the drug
Antifungal medicines like Itraconazole, Ketoconazole and Posaconazole
Antiretroviral therapy
Antibiotics like Erythromycin, Clarithromycin or Telithromycin
Antidepressants like Nefazodone
Cholesterol-lowering medicine like Gemfibrozil
Drugs related to Ciclosporin

Side effects of Simvastatin

Common side effects of this drug are:

Side effects of this medicine are rarely reported, and they may include muscle pain, tenderness, weakness, signs of kidney problems, liver problems, stomach pain, nausea and vomiting.

Precautions and Warnings of Simvastatin

Pregnancy

Can I take Simvastatin during pregnancy?

Do not take Simvastatin if you are pregnant or are planning a pregnancy or if you get pregnant while taking Simvastatin. Stop taking the medicine and see your doctor immediately. You should stop the medication of Simvastatin 1 month before trying to be pregnant.

Breast Feeding

Can I take Simvastatin while breastfeeding?

Do not take Simvastatin if you are breastfeeding because it is unknown if Simvastatin passes into the breast milk.

Driving

Can I drive if I have consumed Simvastatin?

Simvastatin can cause dizziness so make sure you are not affected before you drive.

Alcohol

Can I consume alcohol with Simvastatin?

There are no specific health risks associated with drinking alcohol while using Statins. Alcohol won’t immediately interfere with the Statins in your body. However, heavy drinkers or those who already have liver damage due to heavy drinking could be at higher risk for more severe side effects.

Other General Warnings

Talk to your doctor if

Tell your doctor before taking Simvastatin if you have had an allergic reaction to Simvastatin or any other medicines in the past, have liver or kidney problems, have severe lung disease, have an unde...

Mode of Action of Simvastatin

How Does It Work?

This medicine acts by competitively inhibiting a chemical (HMG-CoA reductase), the first and most crucial limiting enzyme of the cholesterol pathway.

Interactions of Simvastatin

Interactions with other medicines

Some medicines don't mix well with Simvastatin, including:
Some antibiotics and antifungals
Some HIV medicines
Some Hepatitis C medicines
Warfarin (stops blood clotting)
Cyclosporin (treats psoriasis and rheumatoid arthritis)
Danazol (treats endometriosis)
Nefazodone (treats depression)
Amiodarone (makes your heart stable)
Verapamil, Diltiazem, Amlodipine (for high blood pressure and heart problems)

Interactions with food items

Grapefruit juice can interfere with how your body handles Simvastatin. You should not drink grapefruit juice if you are taking Simvastatin.

Dietary Restrictions of Simvastatin

Eat a low-fat, low-cholesterol diet. Be sure to follow all the exercise and dietary suggestions made by your doctor or dietitian.

Dosage of Simvastatin

Overdose

Simvastatin overdose symptoms are not reported. Seek emergency medical attention if you think you have had an overdose of Simvastatin.

Missed a Dose

Take medicine as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to the regular dosing schedule. Do not double the dose to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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