Orlistat

Q: What should I inform the doctor before taking this medicine?

Inform doctor: , If you are taking a medicine for high blood pressure or high cholesterol or on thyroid medicine (Levothyroxine) as it may be necessary to adjust your dose , If you have any gastrointestinal problems or liver problems , If you had any previous surgeries

Molecule Description

Orlistat belongs to the class of medicines called gastrointestinal lipase inhib

itors that are used to control obesity.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Orlistat

Used for obesity management: by aiding in weight loss
Reduce the risk of regaining weight which is already lost

Contraindications of Orlistat

When should one not use Orlistat

Do not take this medicine if you are suffering from malabsorption, allergic reaction to Orlistat or reduced gallbladder function.

Side effects of Orlistat

Common side effects of this drug are:

Oily or fatty stools
Oily spotting on undergarments
Gas and oily discharge from the bowel
Increased number of bowel movements
Stomach pain
Nausea
Rectal pain
Severe pain in lower back
Upper stomach pain
Itching
Tired feeling
Loss of appetite
Dark urine, clay-colored stools and jaundice (yellowing of the skin and eyes)

Precautions and Warnings of Orlistat

Pregnancy

Can I take Orlistat during pregnancy?

Tell your doctor if you are pregnant, planning a pregnancy. Do not take Orlistat if you are pregnant.

Breast Feeding

Can I take Orlistat while breastfeeding?

You must not breastfeed your infant during treatment with Orlistat as it is unknown whether this medicine passes into human milk.

Driving

Can I drive if I have consumed Orlistat?

No known effect on your ability to drive a vehicle.

Alcohol

Can I consume alcohol with Orlistat?

No known interction. Consult with doctor while on this medication.

Other General Warnings

Talk to your doctor if

You have diabetes
You have kidney disease. Use of Orlistat may be associated with kidney stones in patients suffering from chronic kidney disease

Mode of Action of Orlistat

How Does It Work?

It works in your digestive system by blocking nearly one-third of the fat in the food from being digested. Orlistat attaches to the enzymes in your digestive system (lipases) and prevents them from br...

Interactions of Orlistat

Interactions with other medicines

Cyclosporine
Warfarin (blood-thinning medicine)
Amiodarone
Insulin or oral anti-diabetes medicine like Acarbose
Seizure medication (especially if your seizures get worse while taking orlistat)
Vitamin or mineral supplement that contains Beta Carotene or vitamin E
If you are taking any over-the-counter medicines or any other herbal medicines

Interactions with food items

It can be taken immediately before a meal, during a meal or up to one hour after a meal. No food interaction is reported.

Dietary Restrictions of Orlistat

No information is available on dietary restrictions while you are taking Orlistat, consult your doctor or pharmacist for further information.

Dosage of Orlistat

Overdose

The symptoms of an overdose of orlistat are not reported. They are presumably the same as the pronounced side effects, which include: nausea, vomiting, diarrhea, gas, abdominal distress, oily stools a...

Missed a Dose

Take the missed dose as soon as you remember but no more than one hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take medicine at your next r...

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Can I use this medicine in children?

A: This medicine must not be taken by children and adolescents under 18 years old.

Q: What should I inform the doctor before taking this medicine?

Inform doctor:
If you are taking a medicine for high blood pressure or high cholesterol or on thyroid medicine (Levothyroxine) as it may be necessary to adjust your dose
If you have any gastrointestinal problems or liver problems
If you had any previous surgeries

Q: Will this medicine be absorbed into blood?

A: Systemic absorption of Orlistat is minimal, however systemic absorption of the drug is not needed for activity.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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