Norfloxacin+Tinidazole

• Diarrhoea
• Dysentery

When should one not use Norfloxacin+Tinidazole

• If you are allergic to this medicine or any other components of Norfloxacin+Tinidazole.
• If you have a history of a tendon (tissue joining muscle to bone) infection or tendon rupture or damage with any medicine.
• If you are pregnant or breastfeeding.
• If you have a brain and nerves-related problem.
• If you have a history or any disorder related to blood.
• If you are suffering from muscle weakness due to myasthenia gravis.

Common side effects of this drug are:

• Headache
• Dizziness
• Nausea
• Vomiting
• Stomach cramps
• Body pain
• Weakness

Other General Warnings

• You have tendon or nerve problems.
• You have a condition that causes muscle weakness.
• You have problems with your heart like irregular heartbeats, abnormal heart rhythm, and slow heartbeat.
• You have problems with your kidney, liver or lung.
• You are pregnant or are planning to have a baby or are breastfeeding.
• You have fits, restlessness, light-headedness, confusion, and hallucinations or are suffering from a brain disorder.
• You have rheumatoid arthritis or a history of joint issues.
• You have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• You must avoid being in the sunlight for too long as Norfloxacin+Tinidazole may make you more sensitive to the sun.
• You are above 60 years of age, as older people may be at the risk of developing tendon disorders like tendon rupture.
• Patient on this treatment should drink enough water to keep the body hydrated as this medicine increases the chances of crystal formation in urine.
• Norfloxacin+Tinidazole is not recommended in patients below 18 years of age as their safety and efficacy have not been established.

How Does It Work?

• The combination of Norfloxacin+Tinidazole kills bacteria and protozoa that are responsible for diarrhoea.
• Norfloxacin is an antibiotic that damages the bacterial DNA and eventually kills them. It helps in clearing different types of bacterial infections.
• Tinidazole is an antiprotozoal and antibacterial agent that produces free radicals and damages the cells and DNA of protozoa.

Interactions with other medicines

• Concomitant use of this medicine along with Theophylline, may cause headache, insomnia, irritability, restlessness, fits, diarrhoea, nausea, vomiting, skin rash, shaking, and fast heart rate.
• Concomitant use with blood thinners like warfarin, coumadin, etc. may enhance the effects of these medicines.
• The use of antidiabetics like Glyburide, along with this medicine, can affect your blood sugar level. The doctor may ask you to monitor blood sugar level regularly.
• Multivitamins (containing iron, & zinc), antacids, sucralfate, and didanosine should not be consumed together with this medicine. These medicines should be taken either 2 hours before or 2 hours after taking this medicine.
• Concomitant use of Norfloxacin+Tinidazole along with Nitrofurantoin (used to treat infection) is not recommended as it may alter the effects of Norfloxacin.
• Concomitant use of this medicine along with NSAIDs (Aspirin, Ibuprofen, etc.), may increase the risk of having fits or seizures. Hence, it should be used with caution.
• You should be cautious when taking this medicine along with caffeine, Clozapine, Ropinirole, Tacrine and Tizanidine.
• Medicines like Phenobarbital, Phenytoin (used in epilepsy), Rifampin (used in tuberculosis), Cholestyramine (used to decrease blood cholesterol levels), Oxytetracycline (used in infections) decreases the effectiveness of Norfloxacin+Tinidazole.
• Medicines like Cimetidine (used in stomach and intestinal ulcers) and Ketoconazole (fungal infections) increases the chances of side effects of Norfloxacin+Tinidazole in the body.
• Other medicines like Cyclosporine, Probenecid, Erythromycin, Hydrochlorothiazide, Fluorouracil, Indapamide, Digoxin, and Lithium should be used cautiously along with Norfloxacin+Tinidazole.

Interactions with food items

Overdose

Missed a Dose