Minocycline

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Molecule Description

Minocycline is a broad-spectrum antibiotic from the group Tetracycline. It used for treatment of bacterial infections.

Uses

Urinary tract infections
Respiratory infections
Skin infections including acne
Gonorrhea (Gonococcal Infection)
Syphilis
Infective Endocarditis
Chlamydial infection

Contraindications

When should one not use Minocycline

If you are allergic to this medicine
If you have a history of kidney failure or if you are on dialysis treatment
If you suffer from myasthenia gravis (a disease that can cause muscle weakness)

Side effects

Common side effects of this drug are:

Nausea, diarrhea
Head pain
Loss of appetite
Joint pain
Drowsiness and
Dizziness
Discoloration of teeth
Itching, hives, rash and yellowing of the skin or eyes
Kidney complaints – less urine, painful urination and swelling of feet
Liver complaints – nausea, vomiting, stomach pain and jaundice
Brain symptoms – severe head pain, dizziness and vision
problems

Precautions and Warnings

Pregnancy

Do not take Minocycline if you are pregnant or planning a pregnancy as it can affect the development of your unborn baby.

Breast Feeding

Do not breastfeed if you are taking Minocycline as it can pass into breast milk.

Driving

Taking this medicine may lead to cause dizziness, headache. Do not drive until you feel well.

Alcohol

Avoid alcohol and tobacco while on Minocycline as it may lead to cause dizziness.

Other General Warnings

Talk to your doctor if

You have any liver or kidney problems, muscle weakness
You experience during treatment difficulty in breathing, hair loss, joint pain, rash on face

Mode of Action

How Does It Work?

Minocycline is used to treat different bacterial infections affecting the urinary tract, respiratory system, skin infections, etc.

Interactions

Interactions with other medicines

Isotretinoin
Penicillin antibiotic - Amoxicillin, Ampicillin, Penicillin, and others
Blood thinner - Warfarin, Coumadin, etc.
Ergot medicine - Dihydroergotamine, and Ergotamine
One should not take iron supplements, multivitamins, antacids, or laxatives two hours before or after taking Minocycline. They make this medicine less effective

Interactions with food items

No specific interactions with food have been reported yet. Drink plenty of liquids to prevent dehydration when on this medicine.

Dietary Restrictions

No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for further information.

Dosage

Overdose

Overdose symptoms may include dizziness, nausea or vomiting. Seek emergency medical care immediately.

Missed a Dose

Take your missed dose as early as you possible. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Inform the doctor about your detailed medical & surgical historyInform your physician if you have any of the following conditions-Liver diseaseKidney diseaseAsthmaIf you are pregnant, lactating or planning a pregnancyInform the doctor if you are taking hormonal birth control pillsMinocycline can make them less productive; so the doctor would need to prescribe you a non-hormonal birth control measureInform the doctor about the list of medicines you are takingCertain medicines do not act well when taken along with Minocycline

Minocycline should be taken in the exact dose as advised by the physicianTake this medicine with a glass of water. It can be taken with or without food

Always complete the full course of treatment. You may start feeling better with the first few doses of the medicine but complete the course to kill all the bacteria or it will lead to antibiotic resistance.

Minocycline passes either directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. It binds to the 30S ribosomal subunit present inside the bacterial cell, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis, thereby prevents the multiplication of bacteria and bacterial cell death.