Mexiletine

Uses	Ventricular arrhythmias
Therapy	Anti-Arrhythmic
Side Effects	Nausea, Vomiting, Heartburn, Change in appetite, Headache, Skin rashes

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Molecule Description

Mexiletine belongs to a group of medicines called "antiarrhythmics". Mexiletine is used for treatment of irregular and abnormal heart rhythms. It is used to restore normal heart rhythm and maintain a regular heartbeat.

Uses

Ventricular arrhythmias

Contraindications

When should one not use Mexiletine

If you have cardiogenic shock or pre-existing second or third degree AV block (if no pacemaker is present)
If you are pregnant (use only if your doctor has specifically advised it)

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Heartburn
Change in appetite
Headache
Skin rashes

Precautions and Warnings

Pregnancy

If you are pregnant, take Mexiletine only when your doctor has told you to, as it has potential to harm the baby.

Breast Feeding

Consult your doctor before breastfeeding. This medicine is secreted into the milk.

Driving

This medicine can sometimes cause dizziness or lightheadedness. If you develop such symptoms, do not drive.

Alcohol

When used with alcohol, Mexiletine may produce extreme drowsiness.

Other General Warnings

Talk to your doctor if

You are taking vitamins, nutritional supplements, and herbal products
You have allergy to mexiletine
You have allergy to lidocaine
You have history of heart attack, heart failure, low blood pressure, or heart rhythm disorders
You have liver impairment or seizures

Mode of Action

How Does It Work?

This medicine works by blocking certain electrical signals in the heart to stabilize the heart rhythm.

Interactions

Interactions with other medicines

Administering Mexiletine with caffeine can lower its urine levels by 50%
Giving Mexiletine with theophylline may increase its urine level
Medications like cimetidine, fluvoxamine, propafenone, rifampin, anti-seizure medicines (such as phenytoin, phenobarbital) can affect the removal of mexiletine from your body, which may affect how mexiletine works

Dosage

Overdose

In case of overdose or any unexpected symptoms like trouble in breathing rush to the nearest hospital and consult a physician.

Missed a Dose

If you miss a dose, take it as soon as you remember. If the next dose is approaching, skip the missing dose. Use your next dose at the same time every day. To catch up, do not increase the dose. Do not take two doses at a time.

Frequently Asked Questions (FAQs)

Stopping this medicine suddenly can lead to arrhythmias, which can be dangerous. Do not try to discontinue taking this prescription without consulting your doctor.

Yes, Mexiletine can harm your liver. This can happen within a few weeks of starting the medication. It is more common in heart failure patients.

Mexiletine may lower your heart rate. As a result, when you start using Mexiletine, you will almost certainly be admitted to the hospital. During this time, and for as long as you take Mexiletine, your doctor will keep a close eye on you.

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References:

Mexiletine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2022 [cited 11 Jun 2026].

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