Metolazone

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Molecule Description

Metolazone is a Thiazide-like Diuretic (water pill) which is primarily used to treat congestive heart failure and high blood pressure.

Uses

Treatment of high blood pressure (hypertension)
Reduce swelling or fluid retention (edema) which can result from conditions such as congestive heart failure or kidney disease
Lowering high blood pressure helps prevent kidney problems, stroke, heart attacks

Contraindications

When should one not use Metolazone

Anuria (not passing urine)
Hepatic coma or pre-coma
Known allergy to this medicine or sulfonamides

Side effects

Common side effects of this drug are:

Dizziness
Lightheadedness
Drowsiness
Headache
Blurred vision
Loss of appetite
Diarrhea or constipation
Depression
Orthostatic hypotension (decrease in blood pressure)
Hypokalemia (decreased potassium levels)
Hypomagnesaemia (decreased magnesium levels)
Hyponatremia (decreased Sodium levels)
Hypophosphatemia (decreased phosphate levels)
Hyperglycemia (increased blood sugar levels)
Hypercalcemia (increased calcium levels)

Precautions and Warnings

Pregnancy

Taking this medicine during pregnancy is not safe as it appears in cord blood and crosses the placenta; it is not recommended in pre-eclampsia and other pregnancy-induced hypertension.

Breast Feeding

This medicine passes into breast milk; it is not safe to use during breastfeeding.

Driving

This medicine can cause dizziness or blurred vision. Do not drive until you feel well.

Alcohol

This medicine has interactions with alcoholConsuming alcohol may drastically reduce blood pressure

Other General Warnings

Talk to your doctor if

Reduce potassium levels in your blood. Consult your doctor for adding potassium to your diet.

Mode of Action

How Does It Work?

The actions of this medicine result from blocking the reabsorption of sodium ions in distal tubules of kidneys at the time of formation of urine; this can cause an increase in the excretion of water and sodium, potassium and hydrogen ions.

Interactions

Interactions with other medicines

This medicine interacts with numerous medicines. Do not take this medicine without doctor’s advice.

Interactions with food items

No food interaction found yet.

Dosage

Overdose

Overdose symptoms may include fainting, severe weakness, a severe decrease in the amount of urine, slow or shallow breathing, etc. Seek emergency medical attention immediately if you think you have used too much of this medicine.

Missed a Dose

Take your missed dose as early as you possible. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

You should not use this medicine if you are allergic to it or any other Diuretic medicine. Give a detailed account of all your medical and surgical history and show all your previous and recent blood reports to your doctor. Also, tell your doctor about all the ongoing medicines, herbal medicines or nutritional supplements that you may be taking, before starting on this medicine.

Store this medicine at room temperature and away from moisture and sunlight. Keep out of reach of children.

Metolazone can be taken with or without food. Take this medicine at or around the same time every day. Follow the directions on your prescription label carefully and instructions given by your doctor.

Safety and efficacy in children under 12 years has not been established, hence avoided in children.

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