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Molecule Description

Levosulpiride is an atypical antipsychotic medication used in the treatment of nausea, vomiting, heartburn, schizophrenia, depression, etc.

Uses of Levosulpiride

  • Stomach acid reflux (acid moves back into the oesophagus from the stomach)
  • Stomach discomfort – loss of appetite, pain, tenderness, heartburn, loose motions, constipation, etc. (dyspeptic syndrome and irritable bowel syndrome)
  • Unexplained headache (mostly after meals)
  • Nausea and vomiting (associated with anti-cancer medicines) Dizziness
  • Depression (feeling low, losing interest, etc.)
  • Schizophrenia (thinking and behavioral changes, delusions, hallucination - an affected person loses touch with reality.

Contraindications of Levosulpiride

When should one not use Levosulpiride

  • If you have an allergy to Levosulpiride or any of its components
  • If you have epilepsy or extreme mood swings (feeling very high (mania) or shallow (severe depression))
  • Pheochromocytoma (cancer of the adrenal gland that causes fatal and very high blood pressure. It is present above the kidney and produces hormones like adrenaline that regulate metabolism, blood pressure, etc. and steroids)
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Side effects of Levosulpiride

Common side effects of this drug are:

  • Absence of menstrual periods (amenorrhea)
  • Swelling of breasts in men (gynecomastia)
  • Changes in sex drive
  • Milk discharge from the nipples when not breastfeeding, usually in women (galactorrhea)
  • A potentially fatal condition with high fever, fast heart rate and breathing, confusion, sweating, irregular pulse, altered mental state (neuroleptic malignant syndrome)these are rare but serious

Precautions and Warnings of Levosulpiride


Can I take Levosulpiride during pregnancy?
Not recommended if pregnant as Levosulpride can cross the placenta and can harm the unborn baby.

Breast Feeding

Can I take Levosulpiride while breastfeeding?
It is recommended to avoid breastfeeding while taking Levosulpiride as it can be secreted in breast milk and can harm the baby.


Can I drive if I have consumed Levosulpiride?
Levosulpiride can cause side effects like drowsiness, unintentional movements (dyskinesia), numbness and it is advised not to drive while taking this medicine.


Can I consume alcohol with Levosulpiride?
Alcohol can cause the formation of blood clots when used with antipsychotic medicines. Hence consumption of alcohol while taking Levosulpiride is not recommended.

Other General Warnings

Talk to your doctor if
  • You have a history of brain stroke (blocked or ruptured blood vessels in the brain), blood clotting disorders or other ailments of the heart and blood vessels
  • This medicine should be used with caution in patients who are suffering from diabetes or if exposed to the risk factors

Mode of Action of Levosulpiride

How Does It Work?

Dopamine is a substance naturally produced in the body which transmits signals in the brain. It is mainly concerned with mood and behavioral changes. The activity of dopamine is increased in depressive disorders and schizophrenia (thought and behavioral disorder). Levosulpiride acts by blocking the action of dopamine and thereby improve depression. In lower doses, Levosulpiride has gut motility improving properties and is used to treat reflux of stomach acid and stomach movement disorders like constipation, loose motions, etc.
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Interactions of Levosulpiride

Interactions with other medicines

  • Medicines which neutralize stomach acid (such as Sucralfate, aluminium and magnesium-containing antacids)
  • The effect of Levosulpiride on stomach and gut motility may be reduced by Atropine, Dicyclomine (anticholinergic agents), Narcotics (cannabis, cocaine, etc.) and painkillers (Ibuprofen, Mefenamic Acid, Diclofenac, Aspirin, etc.)
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  • In any case, remember to inform your doctor about all the medications that you are taking

Interactions with food items

Levosulpiride may interact with food. It is recommended to be taken 15-30 minutes before a meal.

Dietary Restrictions of Levosulpiride

No information is available on dietary restrictions while you are taking Levosulpiride, consult your doctor or pharmacist for further information.

Dosage of Levosulpiride


Accidental overdose in a small amount of Levosulpiride may not be harmful. But high doses can cause sleep disorders, restlessness, involuntary muscle movements, tremors, etc. If you experience any such symptoms, inform your doctor immediately or seek medical attention.
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Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose and do not take two doses together to compensate for the missed dose.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Levosulpiride?

  • Inform the doctor about your detailed medical, surgical and allery history
  • Inform your physician if you have any of the following conditions:
  • Liver disease
  • History of gastrointestinal bleeding or intestinal obstruction
  • Kidney disease
  • Heart disease
  • If you are pregnant, lactating or planning a pregnancy

Q: Is there anything else I should know about Levosulpiride?

A: Do not self-medicate or self-adjust the dose with Levosulpiride. Levosulpiride is used to control vomiting mostly in patients on cancer therapy and it is not advised to be taken to reduce vomiting in non-cancer patients. Inform your doctor if you want to stop or need to change the dose. It is advisable to drink plenty of water while taking Levosulpiride.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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