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Molecule Description

Glipizide belongs to a class of medicines called Sulfonylureas. This helps to lower the blood sugar and restores the way you use food to make energy.

Uses of Glipizide

It is used to treat Type 2 diabetes (NIDDM-non insulin dependant diabetes mellitus).

Contraindications of Glipizide

When should one not use Glipizide

  • If you are allergic to Glipizide or any other Sulphonamides
  • If you are taking any antifungal medicine to treat fungal infection
  • If you have thyroid problems also if you have ketones and sugar in your urine (diabetic ketoacidosis)
  • If you feel unconscious, do not take this medicine
  • If you are pregnant or planning a pregnancy

Side effects of Glipizide

Common side effects of this drug are:

  • Low blood sugar (hypoglycemia)
  • Decrease in blood cells and blood platelates
  • Diarrhea
  • Breathing difficulty
  • Swelling face, rash, itching

Precautions and Warnings of Glipizide


Can I take Glipizide during pregnancy?
This medication should not be given to a pregnant woman or if you are planning for pregnancy.

Breast Feeding

Can I take Glipizide while breastfeeding?
Do not take Glipizide if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.


Can I drive if I have consumed Glipizide?
If you are driving, you should take special care, as your ability to concentrate may be affected if your diabetes is not well controlled. You may be advised to check your blood sugar levels before you travel and have a snack with you on long journeys.


Can I consume alcohol with Glipizide?
Alcohol can intensify the side effects of Glipizide. Avoid consumption of alcohol when on Glipizide.

Other General Warnings

Talk to your doctor if
  • You have kidney, heart, or liver disease
  • You have digestive problems
  • You have a history of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency
  • You have a history of anemia

Mode of Action of Glipizide

How Does It Work?

Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called Type 2 diabetes. In Type 2 diabetes, too much glucose is produced due to a lack of insulin in the body, and your body does not function properly to store excess sugar, and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. It helps your body to use insulin better.
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Interactions of Glipizide

Interactions with other medicines

  • Medicines used to treat fungal infections (Fluconazole or Voriconazole)
  • Medicines used to treat muscle and joint pain like Phenylbutazone
  • Medicines like Propranolol, Captopril, used to treat high blood pressure and certain heart conditions
  • Medicines used to treat bacterial infections (Quinolones)
  • Medicines used to treat depression and gout
  • Blood thinners like Warfarin
  • Medicines to treat bacterial infections called Quinolones (like Ciprofloxacin)
  • Medicines used to treat psychiatric conditions e.g., Chlorpromazine, Thioridazine
  • Medicines used to treat inflammatory conditions like Prednisolone
  • Oral contraceptives (the pill) and Hormone Replacement Therapy (HRT)
  • Medicines used to treat epilepsy like Phenytoin
  • Medicines used to treat tuberculosis like Isoniazid

Interactions with food items

Medicines can interact with certain foods; this may be harmful in some cases, and your doctor may advise you to avoid certain foods. In the case of Glipizide, there are no specific foods that you must exclude from your diet.
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Dietary Restrictions of Glipizide

No information is available on dietary restrictions while you are taking Glipizide, consult your doctor or pharmacist for details.

Dosage of Glipizide


It is likely that your blood sugar levels have gone too low (hypoglycemia) in the event of overdose. Immediately consume some sugar or sugar-containing drinks and report to the emergency medical care unit.
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Missed a Dose

Take medicine as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and go back to the regular dosing schedule. Do not use extra medicine to compensate for the missed dose.
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Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Why is beta-blockers like Propranolol not recommended with Glipizide?

A: Beta-blockers (e.g., Propranolol) blocks the signs and symptoms like sweating, tremors, etc. of excessive fall in blood sugar levels. They may lead to hide signs of low blood sugar.

Q: Can I take this medicine if I have an allergy to sulfa medicines?

A: Glipizide belongs to the Sulfonylurea group, which contains sulfa content; hence, this medicine should not be taken by patients with sulfa allergy.

Q: What should I discuss with the health care provider before taking the medicine?

A: Inform the doctor if you have G6PD deficiency (an inherited condition causing premature destruction of red blood cells) or having sulfa allergy and the relevant medical and surgical history, your past and ongoing medicines, etc.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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