Febuxostat
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Molecule Description
Febuxostat is a medication used to treat gout, a condition caused by high levels of uric acid (urate) in the body. It works by reducing uric acid production, helping to prevent gout attacks, joint pain, and inflammation. Febuxostat should be taken exactly as prescribed by your doctor, and regular monitoring of uric acid levels may be recommended to ensure effective treatment. Maintaining a healthy diet, staying hydrated, and avoiding alcohol can also help manage gout alongside this medication.
Uses
- Mainly used in the treatment of chronic gout.
- In other hyperuricemic conditions (increased uric acid level in blood), but very rarely.
Contraindications
When should one not use Febuxostat
Do not take it if you have any allergic reactions to Febuxostat.
Side effects
Common side effects of this drug are:
- Nausea, diarrhoea, joint pain, headache
- Increased liver enzyme levels and rash
- Sometimes severe allergic reactions.
- Swelling
- Hot flushes
- Severe skin reactions like blisters, shading of skin, rashes (Stevens-Johnson syndrome)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have heart problems
- You have renal disease
- You have serious allergic reaction to Allopurinol (a medication used for the treatment of Gout)
- You have liver disease
- You have thyroid problems
- While starting treatment with this medicine, you may get gout flare up. However, continue taking medicine
Mode of Action
How Does It Work?
- Gout is associated with increased uric acid levels.
- Febuxostat blocks an enzyme in the production of this uric acid and lowers its level.
Interactions
Interactions with other medicines
- Medicines used to treat cancer (Mercaptopurine).
- Medicines used to reduce immune response (Azathioprine).
- Medicines used to treat asthma (Theophylline).
Interactions with food items
No information is available on interactions of this when taken with food, consult your doctor or pharmacist for further information.
Dietary Restrictions
Avoid meat, beef as these can increase uric acid levels. You are advised to maintain a good amount of water intake while on this medicine.
Dosage
Overdose
Symptoms of overdose of Febuxostat may include dizziness, nausea, vomiting, rash, headache, etc. Seek emergency medical care immediately.
Missed a Dose
If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.
Frequently Asked Questions (FAQs)
Articles
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References:
- Thornton & Ross Ltd. Febuxostat 80 mg Film-Coated Tablets: Summary of Product Characteristics [Internet]. London: electronic Medicines Compendium (emc); [cited 2025 Sep 16].
- Mayo Clinic Staff. Gout diet: What's allowed, what's not [Internet]. Rochester (MN): Mayo Clinic; [cited 2025 Sep 16].
- Hikma Pharmaceuticals USA Inc. Febuxostat Tablets: Prescribing Information [Internet]. Bethesda (MD): U.S. National Library of Medicine; [cited 2025 Sep 16].
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