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Febuxostat

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Molecule Description

Febuxostat is a medication used to treat gout, a condition caused by high levels of uric acid (urate) in the body. It works by reducing uric acid production, helping to prevent gout attacks, joint pain, and inflammation. Febuxostat should be taken exactly as prescribed by your doctor, and regular monitoring of uric acid levels may be recommended to ensure effective treatment. Maintaining a healthy diet, staying hydrated, and avoiding alcohol can also help manage gout alongside this medication.

Uses

  • Mainly used in the treatment of chronic gout.
  • In other hyperuricemic conditions (increased uric acid level in blood), but very rarely.

Contraindications

When should one not use Febuxostat

Do not take it if you have any allergic reactions to Febuxostat.

Side effects

Common side effects of this drug are:

  • Nausea, diarrhoea, joint pain, headache
  • Increased liver enzyme levels and rash
  • Sometimes severe allergic reactions.
  • Swelling
  • Hot flushes
  • Severe skin reactions like blisters, shading of skin, rashes (Stevens-Johnson syndrome)

Precautions and Warnings

Pregnancy

Pregnancy

No adequate data about the safety of this medicine in pregnancy. Febuxostat should not be used during pregnancy.

Breast Feeding

Breast Feeding

It is unknown whether Febuxostat may pass into human breast milk. Hence it is unsafe to use if you are breastfeeding or if you are planning to breastfeed.

Driving

Driving

If during Febuxostat treatment, you feel dizziness, sleepiness or blurred vision, try to avoid driving.

Alcohol

Alcohol

No known interaction with alcohol. Alcohol is known to increase uric acid levels in the body and can worsen the underlying condition of gout. Avoid excessive consumption of alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have heart problems
  • You have renal disease
  • You have serious allergic reaction to Allopurinol (a medication used for the treatment of Gout)
  • You have liver disease
  • You have thyroid problems
  • While starting treatment with this medicine, you may get gout flare up. However, continue taking medicine

Mode of Action

How Does It Work?

  • Gout is associated with increased uric acid levels.
  • Febuxostat blocks an enzyme in the production of this uric acid and lowers its level.

Interactions

Interactions with other medicines

  • Medicines used to treat cancer (Mercaptopurine).
  • Medicines used to reduce immune response (Azathioprine).
  • Medicines used to treat asthma (Theophylline).

Interactions with food items

No information is available on interactions of this when taken with food, consult your doctor or pharmacist for further information.

Dietary Restrictions

Avoid meat, beef as these can increase uric acid levels. You are advised to maintain a good amount of water intake while on this medicine.

Dosage

Overdose

Symptoms of overdose of Febuxostat may include dizziness, nausea, vomiting, rash, headache, etc. Seek emergency medical care immediately.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.

Frequently Asked Questions (FAQs)

Febuxostat is a medication used to lower blood uric acid levels. It is commonly prescribed for people with gout, a condition where uric acid crystals build up in the joints, causing pain, swelling, and inflammation. By reducing uric acid levels, Febuxostat helps prevent future gout attacks and long-term joint damage.

Febuxostat works by blocking an enzyme called xanthine oxidase, which is responsible for producing uric acid in the body. Reducing uric acid production helps prevent the formation of crystals that cause gout symptoms and reduces the risk of kidney stones.

Common side effects may include nausea, joint pain, rash, changes in liver enzymes, or mild diarrhoea. Some people may experience gout flares when first starting treatment. Rare but serious side effects include heart problems, severe allergic reactions, or liver issues. Seek medical attention if you notice chest pain, shortness of breath, swelling, or a severe rash.

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