Diloxanide+Ornidazole

Uses	Intestinal infection
Therapy	Anti-Amoebic
Side Effects	Stomach pain, nausea, vomiting, headache, dry mouth

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Molecule Description

Diloxanide+Ornidazole is a combination medicine that contains diloxanide and ornidazole as its active components. It belongs to the class of medicines called anti-amoebics. It is used in the treatment of intestinal and extra-intestinal infection caused by Entamoeba histolytica. It is also used in the treatment of protozoal infections such as giardiasis caused by Giardia lamblia. Diloxanide+Ornidazole works by killing these micro-organisms that are responsible for the infection. It should not be used for children, pregnant and nursing women without consulting a physician. Take it in the recommended dose and duration as prescribed by your doctor for optimal benefits. You may experience abdominal pain, nausea, vomiting, headache as common side effects of this medicine, these are temporary and usually go away on their own. If these symptoms do not resolve or worsen, consult with your doctor.

Uses

It is used to treat diarrhoea, dysentery (intestinal or extra-intestinal amoebiasis). It is also used in the treatment of protozoal infections such as giardiasis, trichomoniasis, etc.

Contraindications

When should one not use Diloxanide+Ornidazole

If you are allergic to ornidazole or Diloxanide or any of the components of this medicine.
If you are pregnant or breastfeeding.
If you have a fits problem or any auto-immune disorder.
If you have muscular pain or any other underlying medical conditions.

Side effects

Common side effects of this drug are:

Stomach pain
Nausea
Vomiting
Headache
Dry mouth, impaired taste
Drowsiness
Flatulence (gas)

Precautions and Warnings

Pregnancy

Diloxanide+Ornidazole should not be used during pregnancy as it may cause harm to the unborn baby majorly during the first trimester. Inform your doctor if you are pregnant or think you may be pregnant.

Breast Feeding

The components of this medicine pass into the breastmilk and may cause harm to the newborn baby. Inform your doctor if you are a nursing mother and take proper medical advice from the doctor.

Driving

Do not drive or do anything that requires mental focus until you know how this medicine affects you. Sometimes you may experience headache, dizziness after taking Diloxanide+Ornidazole, avoid driving.

Alcohol

No, you should not consume alcohol with this medicine at least for 3 days after consuming it, as it may cause undesirable side effects.

Other General Warnings

Talk to your doctor if

You have or had any psychiatric disease or conditions.
You are pregnant or are breastfeeding.
You have fits or any autoimmune disorder.
You have or had a history of any blood disorders.
You have any kidney or liver diseases.
You are already taking any other medications.

Mode of Action

How Does It Work?

Ornidazole inhibits the growth of protozoa by interacting with the DNA of the micro-organism and inhibiting the protein synthesis, thereby leading to the death of the micro-organism.
Diloxanide is a luminal amoebicide, works by killing the infection-causing organisms in the intestine.

Interactions

Interactions with other medicines

Sometimes Diloxanide+Ornidazole may affect the way other medicines work and other medicines may affect how Diloxanide+Ornidazole works if taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
Especially, if you are on certain medications like blood thinners (such as warfarin) or muscle relaxants, antiepileptic medicines like phenytoin, acid-reducing medicines like cimetidine, etc.
Other medicines that should be used with caution are anti-depressants like lithium, selegiline, etc.

Dosage

Overdose

If you have taken too much of this medicine and experience any of the side effects, then contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you have missed taking any dose of Diloxanide+Ornidazole, then take it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule.

Frequently Asked Questions (FAQs)

No, do not stop taking Diloxanide+Ornidazole before the prescribed duration. Your symptoms may improve before the infection is completely cured. You should complete the full course of treatment else there are chances of recurrence of an infection.

Diloxanide+Ornidazole is effective if you take it in the correct dose and for the exact duration as advised by your doctor. If you stop taking this medicine once you start feeling good, the chance of recurrence of the infection increases.

No, do not take a higher dose than the recommended, it may lead to increased side effects. If your symptoms get worse even after taking Diloxanide+Ornidazole, consult your doctor.

Yes, Diloxanide+Ornidazole treats diarrhoea caused by infection with various susceptible organisms.

No, Diloxanide+Ornidazole is not used to treat urinary tract infection.

Drink plenty of fluids to avoid dehydration. Wash your hands and dry them completely after using washrooms. Clean your toilets regularly with disinfectant. Avoid outside or packed food. Eat properly cooked food.

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