Cycloserine

Uses	Tuberculosis
Therapy	Anti-Tubercular
Side Effects	Confusion, Restlessness, Drowsiness, Vertigo, Cardiac Arrhythmia, Folate Deficiency, Hyperreflexia, Dysarthria, Dizziness, Headache

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Molecule Description

Cycloserine is used to treat tuberculosis. It inhibits the formation of the outer sheath of bacteria and helps to treat tuberculosis.

Uses

Cycloserine is primarily used to treat tuberculosis in conjugation with other medicines for tuberculosis. It may also be recommended for urinary tract infections.

Contraindications

When should one not use Cycloserine

Allergic reactions
A disorder in which nerve cell activity in the brain is disturbed (Epilepsy)
Depression
Severe anxiety
Psychosis
Decrease in the blood flow to the kidney (severe renal insufficiency)
Concurrent usage of alcohol

Side effects

Common side effects of this drug are:

Headache
Giddiness
Dizziness
Swelling
Rashes (particularly on face/ tongue/ throat)
Itching
Breathing difficulty
Tingling sensation
Depression
Increased heart rate

Precautions and Warnings

Pregnancy

It is probably unsafe to take this medicine during pregnancy due to a lack of evidence showing safety.

Breast Feeding

It is probably unsafe to take this medicine during breastfeeding as it may pass into breast milk.

Driving

Taking this medicine usually does not affect your ability to drive.

Alcohol

Alcohol should be avoided with this medicine as it causes drowsiness.

Other General Warnings

Talk to your doctor if

Talk to your doctor if you have:
Psychosis
Sleep disturbances
Depression
Fits

Mode of Action

How Does It Work?

Cycloserine works by preventing the growth of certain type of bracterias (Gram-positive and Gram-negative) and also Mycobacterium tuberculosis (bacteria that causes tuberculosis).

Interactions

Interactions with other medicines

Before you start a treatment with Cycloserine, make sure to inform your doctor and healthcare professional about all the medications you use (including prescription and nonprescription medications, and herbal products). Tell your doctor if you are taking any product that causes drowsiness, including alcohol, anti-allergic medicine like (Cetirizine, Diphenhydramine), anti-anxiety medicines (Diazepam, Zolpidem, Alprazolam), muscle relaxant and narcotics.

Interactions with food items

Do not eat grapefruit unless your doctor guides.

Dosage

Overdose

Overdose of Cycloserine may lead to headache, giddiness, fatigue, altered sensation, change in mental condition, etc.

Missed a Dose

Take the missed dose as early as you remember. If you miss a dose; do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

It is recommended to monitor the liver and kidney functions during treatment with Cyclosporine, as it may cause toxicity to the liver and kidneys. During its use, you should not start any new medicine, or discontinue or modify the dosage of Cycloserine, or any other medicines you are taking without talking to your doctor.

It is recommended to use the medicine according to the method prescribed by your doctor. Cycloserine should be mostly taken with food as it reduces the stomach irritation. Your doctor may increase the dosage, based on a blood test.

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References:

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Cycloserine. [Updated 2018 Oct 31].

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