Crizotinib

• Crizotinib is used to treat locally advanced or metastatic non-small-cell lung cancer (NSCLC)

When should one not use Crizotinib

• If you have a known hypersensitivity or severe allergic reaction to crizotinib or any of the inactive ingredients in the capsule formulation.

Common side effects of this drug are:

• Visual disturbances (such as flashes of light, blurred vision, increased sensitivity to light, or floaters)
• Nausea, diarrhoea, vomiting, constipation, and decreased appetite
• Swelling (edema), particularly of the hands, feet, or ankles
• Fatigue
• Increased liver enzymes (transaminases)
• Dizziness and peripheral neuropathy (numbness or tingling)
• Taste disturbance (dysgeusia)
• Rash
• Low white blood cell counts, particularly neutropenia
• Joint or musculoskeletal pain
• Slow heart rate (bradycardia)
• Photosensitivity (increased sensitivity to sunlight)
• Serious heart rhythm problems, including QT interval prolongation
• Serious lung problems, such as interstitial lung disease or pneumonitis
• Severe liver problems, including life-threatening liver injury
• Severe or persistent vision problems, including partial or complete loss of vision
• Kidney problems, including renal cysts or changes in kidney function

Other General Warnings

• You develop a new or worsening cough, shortness of breath, or difficulty breathing, as these may be signs of lung inflammation (pneumonitis).
• You develop yellowing of the skin or eyes, dark urine, or other symptoms that may suggest liver problems.
• You notice new, persistent, or worsening changes in your vision. Report these promptly to your doctor or eye specialist.
• You develop a very slow heartbeat, especially if you also experience dizziness, fainting, or low blood pressure.
• Tell your doctor if you have heart problems, a history of QT prolongation, electrolyte abnormalities, or take medicines that can affect heart rhythm. You may need ECG and electrolyte monitoring.
• If you are being treated for ALK-positive anaplastic large cell lymphoma or inflammatory myofibroblastic tumour, report severe or persistent nausea, vomiting, diarrhoea, or abdominal symptoms promptly.
• Be cautious when driving or operating machinery if you experience visual disturbances such as blurred vision, flashes of light, or increased sensitivity to light.
• Keep all scheduled blood tests, liver-function tests, ECGs, and other monitoring appointments recommended by your doctor.
• Report any new or worsening breathing problems promptly, as serious lung inflammation can occur with crizotinib.
• Report severe or persistent changes in vision promptly.
• Tell your healthcare providers that you are taking crizotinib and follow their instructions regarding medical or eye examinations.
• If you develop persistent nausea or diarrhoea, inform your doctor early and maintain adequate fluid intake as advised.

How Does It Work?

Interactions with other medicines

• Ketoconazole, clarithromycin, and ritonavir may increase crizotinib levels and the risk of side effects. These medicines should generally be avoided with crizotinib unless specifically advised by your doctor.
• Rifampicin, carbamazepine, and St. John’s wort may reduce crizotinib levels and make it less effective. These medicines should generally be avoided with crizotinib.
• Tell your doctor if you take medicines that can affect heart rhythm or slow your heartbeat, as crizotinib can prolong the QT interval and cause a slow heart rate.
• Some medicines that are affected by the CYP3A enzyme may interact with crizotinib and require careful monitoring or dose adjustment.
• Tell your doctor about all prescription and over-the-counter medicines, vitamins, supplements, and herbal products you take. Avoid grapefruit and grapefruit juice while taking crizotinib.

Interactions with food items

Overdose

Missed a Dose