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molecule

Canagliflozin

Molecule Description

Canagliflozin is used to treat Type 2 diabetes in adults and also to reduce the

risk of heart disease in these patients. It belongs to the ‘SGLT-2 (Sodium-Glucose co-Transporter 2) inhibitor’ class of ‘anti-diabetic medicines.’

uses

Uses of Canagliflozin

  • Treatment of Type 2 diabetes along with lifestyle modifications such as changes in diet and exercise
  • A patient can use Canagliflozin alone or in combination with other diabetic medicines (e.g., Glipizide, Glimepiride, Pioglirazone, Sitagliptin, Vildagliptin, Teneligliptin, etc.) to treat Type 2 diabe...
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contraindications

Contraindications of Canagliflozin

When should one not use Canagliflozin

Allergy to Canagliflozin or any other components of this medicine.
sideEffects

Side effects of Canagliflozin

Common side effects of this drug are:

  • Low blood sugars (hypoglycemia) – blurry vision, sweating, trembling, looking pale, tingling of lips, anxiety or confusion
  • Fungal infections of the vagina, penis or foreskin (redness or rashes)
  • Urinary tract infections, or increased urination
  • Excessive thirst, constipation, feeling sick (nausea) changes in blood cholesterol levels
  • Increased red blood cells
  • Rashes, itching, blisters, kidney problems
precautionsAndWarnings

Precautions and Warnings of Canagliflozin

pregnancy

Pregnancy

Q:
Can I take Canagliflozin during pregnancy?
A:
Canagliflozin should not be used in pregnancy as it has the potential to harm the unborn baby.
breastfeeding

Breast Feeding

Q:
Can I take Canagliflozin while breastfeeding?
A:
Canagliflozin secretes in breast milk, and mothers who breast-feed should not intake this medicine in order to prevent any harm to their babies.
driving

Driving

Q:
Can I drive if I have consumed Canagliflozin?
A:
Canagliflozin does not directly affect your ability to drive. But if you have or you are at risk for side effects such as low blood sugar, dehydration or low blood pressure (dizziness), etc., caution is advised.
alcohol

Alcohol

Q:
Can I consume alcohol with Canagliflozin?
A:
Alcohol lowers blood sugar levels and also increases the risk of dehydration and other complication in patients taking Canagliflozin. Hence, these patients are advised to avoid excessive intake of alcohol (occasional drinking is permitted).
otherGeneralWarnings

Other General Warnings

Talk to your doctor if
  • You have Type I diabetes
  • You have severe kidney or liver disease
  • You have or are at risk of heart attacks or any heart disease or brain stroke
  • You have low blood pressure or are on medicines for high blood pressure
  • You had your lower leg cut-off (amputated) below the knee
  • A complication of poorly controlled diabetes (diabetic ketoacidosis) can occur with Canagliflozin. Symptoms include high blood sugars, rapid weight loss, vomiting, nausea, excessive thirst, fast and d...
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  • Pain, swelling, redness of the genitals or the skin between the genitals and anus due to uncontrolled blood sugars (necrotizing fasciitis or Fournier's gangrene) is a serious condition which can occur...
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  • Irritation, itching or discharge from genital organs (due to yeast or fungal infections)
modeOfAction

Mode of Action of Canagliflozin

How Does It Work?

Canagliflozin works by causing the kidneys to increase the excretion of glucose via urine. For this reason, it is beneficial for patients with heart disease, as it decreases fluid levels in the body a...
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interactions

Interactions of Canagliflozin

Interactions with other medicines

  • Antidiabetic medicines like Insulin, Glipizide, Glimepiride, Sitagliptin, Teneligliptin etc.
  • Medicines used to treat high blood pressure (Ramipril, Captopril, Losartan, Amlodipine, Nifedipine, Atenolol, water pills such as Hydrochlorothiazide, etc.)
  • Carbamazepine, Phenytoin or Phenobarbital (anti-seizure medications)
  • Ritonavir or Efavirenz (HIV/AIDs medicines)
  • Rifampicin (used to treat TB)
  • Cholestyramine (lowers blood cholesterol), Digoxin or Digitoxin (to treat heart problems)
  • Dabigatran (blood thinner)

Interactions with food items

It is preferred to take Canagliflozin on an empty stomach, before the first meal of the day.
dietaryRestrictions

Dietary Restrictions of Canagliflozin

  • It is advisable to have a diabetic diet as advised by your doctor or dietician
  • This medicine works best along with a proper diet and exercise
  • Maintain adequate hydration by speaking to your doctor about your water intake
dosage

Dosage of Canagliflozin

Overdose

Unintentional overdose with Canagliflozin may not be harmful. Consult your doctor if you experience any signs of low blood sugar (hypoglycemia), like dizziness, excess sweating, anxiety, headache, or ...
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Missed a Dose

Do not take a higher or a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

^

Q: Is Canagliflozin an effective medicine to treat diabetes?

  • Adults with Type II diabetes should not use Canagliflozin, which is not dependent on Insulin injections. It is recommended to use along with lifestyle changes such as modifications in diet and increas...
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  • It is also approved to use in Type 2 diabetic patients who are at risk for heart diseases (heart attack, stroke, presence of blood clots, etc.) or those who are at risk for kidney disease due to uncon...
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  • Canagliflozin is most beneficial to patients who have Type 2 diabetes and associated heart disease or kidney disease or both or who are at risk of developing these complications
  • The efficacy of Canagliflozin in the control and maintenance of blood sugars (fasting and after-meals), body weight, cholesterol levels, and blood pressure has been demonstrated in various clinical tr...
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Q: Is there anything else I need to know before using Canagliflozin?

  • Canagliflozin causes fluid loss from the body, by way of more glucose excretion by increasing urination. Hence, it is essential to maintain proper hydration while using this medicine. Severe exercise ...
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  • The intake of fluids also depends on your associated conditions. If you have high blood pressure, decreased heart efficiency, or kidney disease, taking excess fluids can cause more harm. Hence discuss...
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  • Canagliflozin must be in use with caution in patients with kidney disease. For patients with mild kidney disease, regular dosing may continue. But, in patients with moderate kidney failure, dosage mus...
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  • Patients with severe kidney (end-stage kidney disease), liver disease and patients with Type 1 diabetes must avoid the use of Canagliflozin
  • Tests for kidney function are mandatory before starting this medicine
  • Patients below 18 years of age should not use Canagliflozin
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.
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