Canagliflozin

Molecule Description

Canagliflozin is used to treat Type 2 diabetes in adults and also to reduce the

risk of heart disease in these patients. It belongs to the ‘SGLT-2 (Sodium-Glucose co-Transporter 2) inhibitor’ class of ‘anti-diabetic medicines.’

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Canagliflozin

Treatment of Type 2 diabetes along with lifestyle modifications such as changes in diet and exercise
A patient can use Canagliflozin alone or in combination with other diabetic medicines (e.g., Glipizide, Glimepiride, Pioglirazone, Sitagliptin, Vildagliptin, Teneligliptin, etc.) to treat Type 2 diabe...
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Contraindications of Canagliflozin

When should one not use Canagliflozin

Allergy to Canagliflozin or any other components of this medicine.

Side effects of Canagliflozin

Common side effects of this drug are:

Low blood sugars (hypoglycemia) – blurry vision, sweating, trembling, looking pale, tingling of lips, anxiety or confusion
Fungal infections of the vagina, penis or foreskin (redness or rashes)
Urinary tract infections, or increased urination
Excessive thirst, constipation, feeling sick (nausea) changes in blood cholesterol levels
Increased red blood cells
Rashes, itching, blisters, kidney problems

Precautions and Warnings of Canagliflozin

Pregnancy

Can I take Canagliflozin during pregnancy?

Canagliflozin should not be used in pregnancy as it has the potential to harm the unborn baby.

Breast Feeding

Can I take Canagliflozin while breastfeeding?

Canagliflozin secretes in breast milk, and mothers who breast-feed should not intake this medicine in order to prevent any harm to their babies.

Driving

Can I drive if I have consumed Canagliflozin?

Canagliflozin does not directly affect your ability to drive. But if you have or you are at risk for side effects such as low blood sugar, dehydration or low blood pressure (dizziness), etc., caution is advised.

Alcohol

Can I consume alcohol with Canagliflozin?

Alcohol lowers blood sugar levels and also increases the risk of dehydration and other complication in patients taking Canagliflozin. Hence, these patients are advised to avoid excessive intake of alcohol (occasional drinking is permitted).

Other General Warnings

Talk to your doctor if

You have Type I diabetes
You have severe kidney or liver disease
You have or are at risk of heart attacks or any heart disease or brain stroke
You have low blood pressure or are on medicines for high blood pressure
You had your lower leg cut-off (amputated) below the knee
A complication of poorly controlled diabetes (diabetic ketoacidosis) can occur with Canagliflozin. Symptoms include high blood sugars, rapid weight loss, vomiting, nausea, excessive thirst, fast and d...
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Pain, swelling, redness of the genitals or the skin between the genitals and anus due to uncontrolled blood sugars (necrotizing fasciitis or Fournier's gangrene) is a serious condition which can occur...
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Irritation, itching or discharge from genital organs (due to yeast or fungal infections)

Mode of Action of Canagliflozin

How Does It Work?

Canagliflozin works by causing the kidneys to increase the excretion of glucose via urine. For this reason, it is beneficial for patients with heart disease, as it decreases fluid levels in the body a...

Interactions of Canagliflozin

Interactions with other medicines

Antidiabetic medicines like Insulin, Glipizide, Glimepiride, Sitagliptin, Teneligliptin etc.
Medicines used to treat high blood pressure (Ramipril, Captopril, Losartan, Amlodipine, Nifedipine, Atenolol, water pills such as Hydrochlorothiazide, etc.)
Carbamazepine, Phenytoin or Phenobarbital (anti-seizure medications)
Ritonavir or Efavirenz (HIV/AIDs medicines)
Rifampicin (used to treat TB)
Cholestyramine (lowers blood cholesterol), Digoxin or Digitoxin (to treat heart problems)
Dabigatran (blood thinner)

Interactions with food items

It is preferred to take Canagliflozin on an empty stomach, before the first meal of the day.

Dietary Restrictions of Canagliflozin

It is advisable to have a diabetic diet as advised by your doctor or dietician
This medicine works best along with a proper diet and exercise
Maintain adequate hydration by speaking to your doctor about your water intake

Dosage of Canagliflozin

Overdose

Unintentional overdose with Canagliflozin may not be harmful. Consult your doctor if you experience any signs of low blood sugar (hypoglycemia), like dizziness, excess sweating, anxiety, headache, or ...

Missed a Dose

Do not take a higher or a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Q: Is Canagliflozin an effective medicine to treat diabetes?

Adults with Type II diabetes should not use Canagliflozin, which is not dependent on Insulin injections. It is recommended to use along with lifestyle changes such as modifications in diet and increas...
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It is also approved to use in Type 2 diabetic patients who are at risk for heart diseases (heart attack, stroke, presence of blood clots, etc.) or those who are at risk for kidney disease due to uncon...
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Canagliflozin is most beneficial to patients who have Type 2 diabetes and associated heart disease or kidney disease or both or who are at risk of developing these complications
The efficacy of Canagliflozin in the control and maintenance of blood sugars (fasting and after-meals), body weight, cholesterol levels, and blood pressure has been demonstrated in various clinical tr...
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Q: Is there anything else I need to know before using Canagliflozin?

Canagliflozin causes fluid loss from the body, by way of more glucose excretion by increasing urination. Hence, it is essential to maintain proper hydration while using this medicine. Severe exercise ...
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The intake of fluids also depends on your associated conditions. If you have high blood pressure, decreased heart efficiency, or kidney disease, taking excess fluids can cause more harm. Hence discuss...
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Canagliflozin must be in use with caution in patients with kidney disease. For patients with mild kidney disease, regular dosing may continue. But, in patients with moderate kidney failure, dosage mus...
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Patients with severe kidney (end-stage kidney disease), liver disease and patients with Type 1 diabetes must avoid the use of Canagliflozin
Tests for kidney function are mandatory before starting this medicine
Patients below 18 years of age should not use Canagliflozin

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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