Bosentan

Uses	Pulmonary Arterial Hypertension (Pah)
Therapy	Drugs For Pulmonary Arterial Hypertension
Side Effects	Headache, Swelling, Abnormal Liver Enzymes

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Molecule Description

Bosentan is a medicine used for treating high blood pressure in the lungs (known as pulmonary arterial hypertension).

Uses

It is used to treat ulcers on fingers and toes, patient with a skin disease called scleroderma.

Contraindications

When should one not use Bosentan

If you have an allergy to Bosentan
If you have moderate to severe liver disease
If you are taking Ciclosporin A medicine
If you are pregnant

Side effects

Common side effects of this drug are:

Decrease in haemoglobin count
Jaundice
Dark coloured urine
Itching of skin
Fainting
Headache
Swelling over legs, ankles, etc
Redness of skin, rash over skin
Loose motions
Nausea and vomiting

Precautions and Warnings

Pregnancy

It is probably unsafe to use this medicine during pregnancy as this can cause an adverse effect in an unborn baby.

Breast Feeding

It is unknown whether this medicine passes into breast milk or not. Therefore, avoid breastfeeding when on this medication.

Driving

This medicine may lead to the cause of blurred vision. Do not drive unless you feel well.

Alcohol

Alcohol has to be avoided when on this medication.

Other General Warnings

Talk to your doctor if

Blood tests are required to see your liver function, haemoglobin count, before you start treatment of Bosentan and each month after using it
It is useful to do urine tests to check for any unwanted effects

Mode of Action

How Does It Work?

It decreases both pulmonary and systemic vascular resistance and causes blood vessels to expand, which results in increased cardiac output without increasing heart rate.

Interactions

Interactions with other medicines

Ciclosporin A
Hormonal contraceptives
Glibenclamide (for diabetes)
Medicines used to prevent rejection of transplanted organs (like Tacrolimus, Sirolimus)
Fluconazole, Ketoconazole, Itraconazole (to treat fungal infections)
Warfarin (an anticoagulant agent)
Sildenafil and Tadalafil

Interactions with food items

No information is available on interactions of Bosentan when taken with food, consult your doctor or pharmacist for further details.

Dosage

Overdose

Symptoms of overdose of Bosentan include dizziness, fainting, fast heartbeat, light-headedness, nausea, severe headache, vomiting, etc. Seek emergency medical attention immediately.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before you start this medication.

Due to the potential for severe liver injury, including rare cases of liver failure, liver function tests must be done before starting the treatment and then periodically after that. This drug makes oral hormonal contraceptives ineffective. Discuss another/ additional form of contraception with your doctor while on this medicine.

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