Bortezomib

Uses	Multiple myeloma, Mantle-cell lymphoma
Therapy	Anti-Neoplastic
Side Effects	Numbness or tingling, pain in hands or feet, fever, nausea, vomiting, loss of appetite, muscle pain, diarrhoea, tiredness

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Molecule Description

Bortezomib is an anticancer medicine used in the treatment of multiple myeloma (a cancer of the bone marrow) and mantle-cell lymphoma (a type of cancer affecting the lymph nodes) in adults. It plays an important role in controlling cell function and growth.

Uses

Treatment of myeloma (a cancer of the bone marrow) and mantle-cell lymphoma (a type of cancer affecting the lymph nodes) in adults.

Contraindications

When should one not use Bortezomib

If you are allergic to bortezomib or any other ingredient of this medicine.

Side effects

Common side effects of this drug are:

Numbness or tingling sensation on skin
Pain in hands or feet
Fever
Nausea
Vomiting
Loss of appetite
Muscle pain
Diarrhoea
Tiredness

Precautions and Warnings

Pregnancy

Bortezomib is not recommended during pregnancy unless clearly considered essential by the doctor. Both men and women receiving this medicine must use effective contraception during and for up to 3 months after treatment.

Pregnancy

If pregnancy occurs even after these measures, tell your doctor immediately.

Breast Feeding

Breastfeeding is not recommended during treatment with Bortezomib.

Driving

You may experience dizziness, tiredness, faint or blurred vision as a side effect during the treatment. So you should avoid driving if you experience these symptoms.

Alcohol

There is no known interaction between alcohol and this medicine. However, it is important to consult your doctor if you drink often. It may be best to avoid alcohol until you have finished treatment.

Other General Warnings

Talk to your doctor if

You have less number of white and red blood cells.
You have any kind of bleeding problems or have a low platelet count.
You experience symptoms like dizziness, lightheadedness, diarrhoea, nausea or vomiting after receiving this medicine.
You have a history or currently have hepatitis. You need to be monitored cautiously for signs of active hepatitis B.
You have liver or kidney problems.
You experience numbness or tingling, and pain in your hands.
You have any pre-existing medical condition such as epilepsy, high blood pressure, heart problems, seizure, shingles (localized including around the eyes or spread across the body) etc.
You experience symptoms like muscle cramping, muscle weakness, confusion, shortness of breath etc. It can be a sign of tumour lysis syndrome.
You experience symptoms like memory loss, trouble thinking, difficulty in walking or vision loss. As it can be a sign of brain infection. You may require follow-up checkups.
The doctor may ask you for regular blood tests, before and after the treatment.
You have lung problems.

Mode of Action

How Does It Work?

Bortezomib works by blocking or slowing the breakdown of proteins (proteasome) in cells, which may stop cancer from growing and eventually cause cancer cells to die.

Interactions

Interactions with other medicines

Some medicines affect the way Bortezomib works or Bortezomib itself reduces the effectiveness of other medicines taken at the same time. Inform the doctor about medicines, supplements or herbals you are taking or might take to avoid possible interactions.
In particular, if you are taking certain medications such as anti-HIV medicine like ritonavir, antifungal medicines like ketoconazole, anti-tuberculosis medicine like rifampicin, anti-epileptic medicine, anti-depressants medicine like St. John's Wort or oral anti-diabetic medicines etc.

Dosage

Overdose

Bortezomib will be given by a doctor or nurse thus the chances of an overdose are unlikely. However, if you experience any discomforts inform the doctor.

Missed a Dose

It is unlikely that the dose of Bortezomib will be missed if you are monitored in a healthcare setup. However, if you have missed taking a dose of the medicine, inform the doctor or nurse immediately.

Frequently Asked Questions (FAQs)

Bortezomib is an anticancer medicine.

Bortezomib works by blocking or slowing the breakdown of proteins (proteasome) in cells, which may stop cancer from growing and eventually cause cancer cells to die.

No, it has no habit forming tendency.

No, it is not recommended to pregnant women unless strictly considered essential by the doctor.

The doctor will decide the specific dose for a specific duration depending upon the severity of the condition and how you respond to the treatment. Do not self-inject.