Bevacizumab

Uses	Anti-cancer
Therapy	Anti-Neoplastic
Side Effects	Nausea, vomiting, weakness, diarrhoea, stomach pain

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Molecule Description

Bevacizumab is an anticancer medication used in the treatment of various types of cancer, including colorectal, breast, lung, kidney, ovarian, fallopian tube, peritoneal, and cervical cancers. It may be used alone or in combination with other cancer medications. It prevents the growth of new blood vessels that feed cancer cells. This medicine will be given to you by a doctor or nurse. Do not self-inject this medicine. Bevacizumab must not be used by pregnant women. Women who are capable of becoming pregnant should use effective birth control during treatment and up to 6 months after treatment with Bevacizumab. This solution for infusion is not to be used in children under 18 years of age. Bevacizumab treatment should be stopped in cases of gastrointestinal perforation or severe bleeding. It should also be paused for at least 28 days before and after any surgery to allow for proper wound healing.

Uses

Contraindications

When should one not use Bevacizumab

If you are allergic to bevacizumab or any other ingredient of this medicine.
If you are allergic to any other recombinant human or humanized antibodies. If you are not sure what these medicines are, please confirm with your doctor.
If you are pregnant.

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Weakness
Diarrhoea
Stomach pain

Precautions and Warnings

Pregnancy

To prevent any risks to the developing baby, Bevacizumab is not recommended during pregnancy.

Breast Feeding

Bevacizumab is not advised during breastfeeding and for at least six months after your last dose.

Driving

Bevacizumab has almost no effect on the driving ability. However, if you experience symptoms like sleepiness and dizziness, which may interfere with your driving ability, it is suggested that you do not drive.

Alcohol

There is limited information on the interaction of Bevacizumab with alcohol. Please discuss with your doctor regarding the consumption of alcohol with Bevacizumab.

Other General Warnings

Talk to your doctor if

You have any condition that causes inflammation of the abdomen, like stomach ulcer, or diverticulitis.
You have cervical cancer.
You recently had or have surgery scheduled soon, including dental surgery.
You have problems with wound healing or have an unhealed wound after surgery.
You have high blood pressure, diabetes, blood clots or bleeding problems.
You have infections that occur frequently.
You have or had pain in the mouth, teeth, jaw, swelling or sores inside the mouth, numbness or a feeling of heaviness in the jaw or loose tooth.
You have a weak blood vessel or a tear in the blood vessel.
You have cancer of the brain or have ever coughed or spitted blood.
You are above 65 years of age.
You have heart disease, received X-ray therapy to your chest or have used medicines called anthracyclines (doxorubicin).
You have previously experienced symptoms like dizziness, swelling or skin rashes, after injection.
You develop symptoms like headaches, and changes in vision, after taking this medicine.

Mode of Action

How Does It Work?

Bevacizumab works by stopping the action of a protein called vascular endothelial growth factor (VEGF) in the body responsible for making the blood vessels grow. As a result, the cancer cells are unable to produce their blood supply and are starved of oxygen and nutrients, which slows down the growth of cancer.

Interactions

Interactions with other medicines

Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
Bevacizumab when used along with sunitinib malate may cause a type of anaemia called microangiopathic haemolytic anaemia (MAHA).
Particular care should be taken if you are taking platinum-based cancer medicines (cisplatin) or taxane-based cancer medicines (paclitaxel).

Dosage

Overdose

The symptom of an overdose of Bevacizumab is severe migraine. However, Bevacizumab will be given to you by a doctor or nurse and hence, the chances of an overdose are unlikely.

Missed a Dose

It is unlikely that a dose of this medicine will be missed if you are monitored in a healthcare setup. However, if you have missed taking a dose of the medicine, inform the doctor or nurse immediately.