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Amantadine

Molecule Description

The medicine is useful for treating both Parkinson’s disease and viral infection, mainly Influenza A virus (i.e., H1N1, H2N2, and H3N2).

Uses of Amantadine

To treat Parkinson’s disease.

Contraindications of Amantadine

When should one not use Amantadine

  • If you are allergic to Amantadine
  • History of Epilepsy or other seizure disorders
  • Severe kidney disease
  • History of ulcer in the stomach or small intestine

Side effects of Amantadine

Common side effects of this drug are:

  • Light headedness
  • Dizziness
  • Nervousness
  • Anxiety
  • Agitation
  • Insomnia
  • Loss of appetite
  • Irritability
  • Hallucinations (seeing, hearing, feeling, smelling, or tasting things that are not there), difficulty in concentration
  • Decrease in sexual activity
  • Constipation
  • Dryness of mouth
  • Blurred vision

Precautions and Warnings of Amantadine

Pregnancy

Q:
Can I take Amantadine during pregnancy?
A:
Do not take this medicine if you are pregnant or planning for pregnancy.

Breast Feeding

Q:
Can I take Amantadine while breastfeeding?
A:
Do not take this medicine if you are breast-feeding as Amantadine passes into breast milk and can harm your baby.

Driving

Q:
Can I drive if I have consumed Amantadine?
A:
This medicine may affect your vision or concentration, you may feel dizzy or confused. You should avoid driving while taking this medicine.

Alcohol

Q:
Can I consume alcohol with Amantadine?
A:
Alcohol may lead to cause dizziness or drowsiness.

Other General Warnings

Talk to your doctor if
  • Talk to your doctor if:
  • You suffer from any liver or kidney disease or heart and blood vessels problems
  • Have any mental health problem like schizophrenia, dementia, hallucinations
  • Have glaucoma (increased pressure in the eye)
  • If your child is under three years of age (Amantadine is not for children under the age of 3 years)

Mode of Action of Amantadine

How Does It Work?

For treatment of Influenza-It mainly acts on Influenza A virus (i.e., H1N1, H2N2, and H3N2). It works by blocking the protein called M2 present in virus, thereby blocking the release of the virus into human cells. It also acts by preventing the multiplication virus in the body. It has little or no effect in treating Influenza B infection. For treatment of Antiparkinson activity: Its mechanism of action is complex and not completely understood. Overactivity of the NMDA receptor can lead to an increase in the neurotransmission and generation of parkinsonian symptoms. By blocking the NMDA receptors, it decreases the overactivity of the NMDA receptor and prevents the parkinsonian symptoms.
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Interactions of Amantadine

Interactions with other medicines

  • Thioridazine: Taking this medicine along with Amantadine can cause tremor to worsen in patients suffering from Parkinson’s disease.
  • Anticholinergic medicines such as Scopolamine, Hydrochlorothiazide, Quinidine, Quinine, stimulant medicines, e.g., Caffeine, Methylphenidate, Pseudoephedrine, or Triamterene, should be avoided while on Amantadine because these medicines increase the risk of the side effects of Amantadine.
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One should not consume alcohol along with Amantadine as it increases the effect of alcohol.

Dosage of Amantadine

Overdose

Inform your doctor immediately in case of overdose.

Missed a Dose

Take the missed dose as early as you remember. If it is the time for next dose, skip the missed dose and follow your regular dosing schedule. If you consider Amantadine for flu, you should take the complete course even if you feel better. The full course helps in eradicating infection.
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Frequently Asked Questions (FAQs)

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Q: What should I discuss with my physician before taking Amantadine?

A: If the person is on any other medication, the doctor should be informed. Information regarding any liver, kidney, or heart disease should be brought into the consciousness of the doctor.

Q: Who should not consume Amantadine?

A: Patients with seizures disorder, renal dysfunction, psychosis, edema, and hypotension should not consume Amantadine. These diseases may increase or exacerbate with Amantadine.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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