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Acetazolamide

Molecule Description

It is a sulphonamide derivative with anticonvulsant, diuretic, and antiglaucoma properties.

Uses of Acetazolamide

  • Glaucoma: a condition of the eye where the pressure in the eye increases
  • Abnormal retention of fluid in the body

Contraindications of Acetazolamide

When should one not use Acetazolamide

  • You are allergic to this or any sulphonamide derivatives
  • Low sodium or potassium blood serum levels
  • Also, do not use in a particular type of glaucoma (chronic noncongestive angle-closure glaucoma)
  • Severe kidney or liver disease

Side effects of Acetazolamide

Common side effects of this drug are:

  • Gastrointestinal disturbances (nausea, vomiting, diarrhea, constipation)
  • Increased urination
  • Headache
  • Loss of appetite
  • Drowsiness
  • Confusion and visual disturbances
  • Tingling in legs
  • Electrolyte imbalance
  • Blood in urine or stools
  • Itching, hives, rash; yellowing of the skin or eyes
  • Convulsions
  • Liver complaints ( loss of appetite, stomach pain, nausea, dark urine, jaundice)
  • Kidney stone

Precautions and Warnings of Acetazolamide

Pregnancy

Q:
Can I take Acetazolamide during pregnancy?
A:
Do not take Acetazolamide in pregnancy. It may be unsafe.

Breast Feeding

Q:
Can I take Acetazolamide while breastfeeding?
A:
During breastfeeding, only on doctor’s advice, one should take this medicine.

Driving

Q:
Can I drive if I have consumed Acetazolamide?
A:
Do not drive if you feel dizzy, tired, or have vision problems after taking Acetazolamide.

Alcohol

Q:
Can I consume alcohol with Acetazolamide?
A:
Acetazolamide may cause drowsiness or temporary vision changes. These effects may be worse if you take alcohol while on treatment with this.

Other General Warnings

Talk to your doctor if
  • Your age is above 60-65
  • You have any lung problems such as Chronic Bronchitis or Emphysema, which cause difficulty in breathing
  • You have or ever had kidney stones or any kidney-related problems

Mode of Action of Acetazolamide

How Does It Work?

It reduces the functioning of an enzyme called Carbonic Anhydrase, which reduces the build-up of fluids. This action is desirable in conditions such as glaucoma and congestive heart failure.

Interactions of Acetazolamide

Interactions with other medicines

  • Medicines for your heart such as Cardiac Glycosides like Digoxin
  • Medications to reduce blood pressure
  • Medicines to thin your blood
  • Medicines to lower the sugar in your blood
  • Medicines for epilepsy or fits
  • Steroids such as Prednisolone
  • Aspirin and related medicines like Salicylic Acid or Choline Salicylate used for mouth ulcers
  • Other in the group of medications called carbonic anhydrase inhibitors like Dorzolamide or Brinzolamide which are also used to treat glaucoma

Dietary Restrictions of Acetazolamide

  • Drink plenty of liquids to prevent dehydration.

Dosage of Acetazolamide

Overdose

If you happen to take an overdose of this medicine, kindly seek medical care immediately. The effects of an overdose include drowsiness, decreased appetite, nausea, vomiting, dizziness, numbness or tingling, shaking, and ringing in the ears. Seek immediate emergency medical attention.
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Missed a Dose

If you missed any dose, take it as soon as you remember it. However, if it is less than 6 hours before you are scheduled to take your next dose, skip the missed dose, and continue your regular dosage schedule. Do not take a double dose to recoup for a missed dose.
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Frequently Asked Questions (FAQs)

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Q: Does Acetazolamide affect blood pressure?

A: Yes, Acetazolamide may decrease blood pressure.

Q: Does Acetazolamide affect eye sight?

A: Yes, Acetazolamide may cause blurred vision. In case the symptom worsens, contact your doctor or pharmacist.

Q: Does Acetazolamide increase urination?

A: Yes, Acetazolamide increase the frequency of urination in the initial few days.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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