What is Abemaciclib used for?

Abemaciclib

Uses	Breast cancer
Therapy	Anti-Neoplastic
Side Effects	Diarrhoea, nausea, vomiting, anaemia, fatigue, headache

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Molecule Description

Abemaciclib belongs to the class of anticancer medicines. Abemaciclib interrupts the process through which cancer cells multiply and divide. It works as a CDK inhibitor. It is prescribed to treat breast cancer in HR-positive and HER2-negative patients. It is a prescription medicine and must be taken only as the doctor advises.

Uses

Abemaciclib is used in combination with endocrine therapy for the treatment of early and advanced or metastatic breast cancer.

Contraindications

When should one not use Abemaciclib

Allergy to the active substance or any of the excipients

Side effects

Common side effects of this drug are:

Diarrhoea
Nausea
Vomiting
Anaemia
Fatigue
Headache
Dizziness
Decreased appetite
Alopecia (hair loss)
Neutropenia (reduced neutrophil count)
Leukopenia (reduced leucocytes count)
Increased risk of infections

Precautions and Warnings

Pregnancy

Abemaciclib is not recommended during pregnancy and in women of childbearing potential not using contraception.

Breast Feeding

Patients receiving Abemaciclib should not breast-feed

Driving

Abemaciclib has a minor influence on the ability to drive and use machines. Patients are advised to be cautious when driving or using machines in case they experience fatigue or dizziness during treatment with Abemaciclib.

Alcohol

No information is available on the interactions of Abemaciclib and alcohol.

Other General Warnings

Talk to your doctor if

You have Diarrhoea
You have signs and symptoms of deep vein thrombosis and pulmonary embolism
You are taking any other medications
You smoke or drink
You have a poor appetite
You have any liver or kidney problems

Mode of Action

How Does It Work?

Abemaciclib is a CDK inhibitor (cyclin-dependent kinase inhibitor) and selectively inhibits CDK4 and CDK6. The CDK4 and CDK6 proteins are found both in healthy cells as well as in cancer cells. They control the multiplication and division of cells. In breast cancer, these proteins can become overactive and cause the cells to grow and divide uncontrollably. CDK4/6 inhibitors like Abemaciclib interrupt these proteins to slow or even stop the cancer cells from growing abnormally.

Interactions

Interactions with other medicines

Some medicines can affect the way Abemaciclib works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.

Dosage

Overdose

In the event of an Abemaciclib overdose, fatigue and diarrhoea may occur. Report to your doctor immediately.

Missed a Dose

If you have missed a dose of Abemaciclib, then take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Frequently Asked Questions (FAQs)

Abemaciclib is an anti-cancer medication used in the treatment of breast cancer. This medicine may be used as an adjunct to hormone therapy in some patients.

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