Gliclazide+Metformin Hydrochloride

Uses	Type 2 diabetes mellitus
Therapy	Anti-Diabetic
Side Effects	Headache, dizziness, nausea, rashes, hot flushes, impaired taste, low blood sugar

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Molecule Description

Gliclazide+Metformin Hydrochloride is an anti-diabetic medicine used to treat type 2 diabetes mellitus. It contains a combination of gliclazide and metformin as active ingredients. It is used along with a healthy diet and regular exercise for the control of high blood sugar in patients having diabetes. Take this medicine as prescribed and for the duration that it is prescribed for by your doctor. It would be best if you took it at a fixed time for optimal results and should not consume it more than that prescribed by your doctor. Also, it is suggested to keep a regular check on blood sugar level during the treatment, either in laboratory or at home if you have the blood glucometer with you.

Uses

Gliclazide+Metformin Hydrochloride is used in the treatment and management of type 2 diabetes mellitus, which has not come under control by diet and exercise alone.

Contraindications

When should one not use Gliclazide+Metformin Hydrochloride

If you are allergic to this medicine or any other ingredients of Gliclazide+Metformin Hydrochloride.
If you have severe liver or kidney problems, or a serious heart or lung condition.
If you consume alcohol in excess.
If you have diabetic pre-coma.
If you are pregnant.
If you have a planned surgery.

Side effects

Common side effects of this drug are:

Headache
Dizziness
Nausea
Rashes
Hot flushes
Impaired taste
Low blood sugar (hypoglycaemia)

Precautions and Warnings

Pregnancy

It is not safe to take this medicine during pregnancy, as it can harm the unborn baby. It is essential to always consult a doctor before starting any medicine during pregnancy. Mostly, in pregnancy-related diabetes, insulin is preferred over any oral medicines.

Breast Feeding

It is advisable to not breastfeed if you are taking this medicine, as it passes into breast milk and may cause harm to the newborn baby.

Driving

No information is available on the ability to drive or use machines. However, do not drive until you know how the medicine affects you. It is suggested to keep sugar or a bar of chocolate in your car with you always, while driving. In case you experience any of the symptoms of low blood glucose levels like dizziness, drowsiness, visual disturbances and sweating, stop driving immediately and have sugar/ juice.

Alcohol

It is advisable not to consume alcohol when you are taking this medicine as it interferes with the way Gliclazide+Metformin Hydrochloride works. Consumption of alcohol during the treatment may lead to an increased risk of low blood glucose level.

Other General Warnings

Talk to your doctor if

You have any known medical condition like liver or kidney related, heart disorder, lung disease, blood-related disorder etc.
You have planned a surgery or undergone through surgery.
You have a history of allergic reaction due to any medicine.

Mode of Action

How Does It Work?

It acts by stimulating insulin secretion from the β-cells of the pancreas and increase the amount of insulin released by the pancreas. It also helps to restore the body's proper response to the insulin it naturally produces.

Interactions

Interactions with other medicines

Gliclazide+Metformin Hydrochloride may interact with other medications and provide an altered response to the treatment. Please notify your doctor if you are undergoing any other treatments, including all prescribed or non-prescribed herbal medicines, dietary supplements as well as other treatment if you are taking for any disorder.
Especially if you are taking any other anti-diabetic medicines like insulin, water pills, anti-hypertensives, medicines for brain and heart-related disorders, anti-epileptic medicines, anti-tuberculosis medicines etc.
Other medicines which may interact with Gliclazide+Metformin Hydrochloride are painkillers, oral contraceptives, antidepressants like alprazolam etc.

Dosage

Overdose

Overdose of Gliclazide+Metformin Hydrochloride can lead to drastic drop in blood sugar level, sweating, drowsiness, irregular heart beat, tremors etc.
If you think you have taken too much of this medicine contact your doctor immediately or visit the nearest hospital.
If you have the blood glucometer with you, test immediately and confirm.
Whether or not you test your levels, it is important to take some glucose water/juice or chocolates immediately and then rush to your doctor.

Missed a Dose

Missed dose may lead to high blood sugar levels which can cause symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness etc.
If you missed any dose of medicine take it as soon as you remember.
Do not take a double dose of medicine to compensate the missed one as taking double dose can cause a drastic fall in blood glucose which can be dangerous.

Frequently Asked Questions (FAQs)

A diet should be high in fibre, low in fat with adequate protein, carbohydrates, vitamins and minerals. Maintain the regular meal timings and try to have 2-3 healthy snacks between meals like soups and salads. Diet should include boiled, steamed, or baked food. Ensure moderate use of edible oils (groundnut oil, olive oil), very less use of ghee and butter. Drink at least 8-10 glasses of water daily

Do not shop when you are hungry. You could be tempted to buy oil and fried food. Avoid overeating Avoid maida, white bread, potato, noodles, corn flakes, poori, biryani, naan, fried rice etc. Avoid cream soups, carrot juice, deep fried vegetables, vegetable curries with excess oil Avoid Seetaphal, mango, jack fruit, fruit salads with ice cream, fruit-based desserts

Risk factors for developing low blood glucose levels include not taking adequate meals or missing meals, too much alcohol consumption, taking other anti-diabetic medicines, fever and too much exercise. Report to your doctor about these episodes. You may need a dose adjustment.

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Gliclazide+Metformin Hydrochloride

Molecule Summary