Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen
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Molecule Summary
| Uses | Joint and muscular pain |
| Therapy | Analgesic/Antipyretic, Muscle Relaxant |
| Side Effects | Dizziness, lightheadedness, nausea, vomiting, weakness, liver problem |
Medicines
available
19k pincodes
Molecule Description
Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen is commonly prescribed to relieve painful muscle spasms, joint inflammation, and musculoskeletal pain. It is also used to ease discomfort after surgery and injuries, helping patients recover faster and improve mobility. By targeting both pain and muscle stiffness, this medication provides comprehensive relief from discomfort associated with bone, joint, and muscle conditions.
The medicine is a combination medicine containing Diclofenac, Paracetamol, and Chlorzoxazone. Diclofenac and Paracetamol decrease pain and inflammation by blocking the release of certain chemical messengers (prostaglandins) that cause swelling and pain. Chlorzoxazone acts as a muscle relaxant, helping to reduce stiffness and facilitate movement. Together, these ingredients provide dual action pain relief and muscle relaxation.
Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen should always be taken at the dose and for the duration specified by your doctor. It can be taken with food to prevent stomach upset. Do not exceed the recommended dose on your own, as overuse may cause side effects. It is important to follow your doctor's advice regarding the length of treatment to ensure safe and effective results.
Possible side effects include nausea, dizziness, stomach discomfort, or drowsiness. These are generally temporary, but if they persist or worsen, seek medical attention. Avoid driving or operating heavy machinery after taking the medicine if you feel drowsy. Additionally, avoid alcohol, as it may increase the risk of stomach irritation and liver problems.
Uses
Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen is used for relieving pain and inflammation of muscles, joints and bones in conditions such as arthritis, spondylitis and injuries. It is also used after operations and surgeries for relieving pain, inflammation and swelling.
Contraindications
When should one not use Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen
- If you are allergic to Diclofenac, Paracetamol, Chlorzoxazone or any ingredient of Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen
- If you are experiencing bleeding from the stomach and intestine or have an active peptic ulcer
- If you are allergic to other painkillers such as aspirin and have experienced severe asthma, rashes or any other allergy
- If you have severe heart failure
- If you have severe kidney or liver problems
- If you are pregnant
- This medicine should not be used for pain during and after bypass surgery of the heart.
Side effects
Common side effects of this drug are:
- Dizziness
- Lightheadedness
- Nausea
- Vomiting
- Weakness
- Fatigue
- Liver problem
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have kidney or liver problems.
- You have heart problems like high blood pressure and heart failure.
- You are an elderly patient taking diuretics or have a kidney disorder, this medicine can increase the risk of kidney failure.
- Your doctor may ask you to do renal function tests for the same.
- You are suffering from gastrointestinal problems like bleeding, ulcers in the intestine (perforation) or Crohn's disease, or you are passing black tarry stools.
- You have asthma, and this medicine can worsen the same.
- You are an alcoholic, then concomitant use of this medicine can damage the liver.
- You have disorders related to blood, like clotting problems and anaemia.
- You have skin rashes & lesions after taking this medicine.
- Elderly patients (65 years of age or older) should use this medicine with caution.
Mode of Action
How Does It Work?
- Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen works by the combined action of its three components. Diclofenac and Paracetamol inhibit the synthesis of prostaglandins, which are responsible for causing pain, swelling, and inflammation thus offering anti-inflammatory properties.
- Chlorzoxazone is a muscle relaxant that works by blocking the signals of painful sensation through the nerve to the brain and reduces pain and stiffness.
Interactions
Interactions with other medicines
- Do not take any other medicines containing Paracetamol or Diclofenac, as there is a risk of liver damage.
- If you are taking medicines for high blood pressure, this medicine can interfere with their effect.
- Medicines like water pills can lead to kidney damage when taken along with them.
- Caution is needed if you are taking medicines to treat heart failure.
- This medicine can increase the levels of lithium and methotrexate. Discuss with your doctor before starting the treatment.
- Medicines used to modify immune response during organ transplant, like ciclosporin & tacrolimus, can result in kidney damage if taken with this medicine.
- Increased risk of stomach ulcers or bleeding when taken with steroids or other pain relief medicines like Aspirin.
- There is a risk of bleeding if you are taking blood-thinning medicines like Warfarin and Coumarin.
- Increased risk of fits if you are taking this medicine with antibiotics like Levofloxacin and Ciprofloxacin.
- If you are taking medicines to treat diabetes, be cautious about symptoms of low glucose levels like sweating, anxiety, fast heartbeat and hunger pangs.
- Medicines used to treat fits, seizures & depression, like Phenobarbital, Carbamazepine, Phenytoin, and Clonazepam, should be used with caution as Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen can increase the side effects of these medicines.
- Medicine used to treat gout, like Probenecid, medicines used to treat bacterial infections, like Chloramphenicol, Rifampicin and HIV infections, like Zidovudine, should be used cautiously.
Interactions with food items
Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen should be taken with food to prevent an upset stomach. It has no specific interactions with food.
Dosage
Overdose
Taking Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen in high doses may result in symptoms of overdose like headache, nausea, vomiting and stomach pain. If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed any dose of Chlorzoxazone+Diclofenac+Paracetamol / Acetaminophen, take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- Anadin Paracetamol Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 12th Jun 2026]
- Anadin Paracetamol Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 12th Jun 2026]
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 2733, Chlorzoxazone. 2025 [cited 12th Jun 2026]
- U.S. Food and Drug Administration. Diclofenac [Internet].
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