S One Trio 20Mg Strip Of 7 Capsules

• If you have a known hypersensitivity to tegafur, gimeracil, oteracil, or any ingredient of this medicine.
• If you have a history of severe, unexpected reactions to similar fluoropyrimidine chemotherapy medicines.
• If you have a known complete deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD).
• If you are pregnant or breastfeeding.
• If you have severe suppression of bone marrow function.
• If you have end-stage kidney disease requiring dialysis.
• If you are taking any other fluoropyrimidine chemotherapy medicine at the same time.
• If you are being treated with, or have recently been treated with, the antiviral medicine brivudine.

• Low neutrophil count, low white blood cell count, anaemia, low platelet count
• Loss of appetite
• Diarrhoea, vomiting, nausea, constipation
• Nerve tingling or numbness (peripheral neuropathy)
• Skin reaction affecting the palms and soles, rash, dry skin, itching, hair loss
• Musculoskeletal pain
• Fatigue, weakness
• Raised bilirubin and liver enzymes (seen on blood tests)

• Infections
• Excess tearing, dry eyes, or other eye irritation
• Blood clots, high or low blood pressure
• Breathlessness, nosebleeds, cough
• Mouth sores, abdominal discomfort
• Fever, weight loss, swelling

• Severe infection or sepsis
• Severe bone marrow suppression
• Reactivation of hepatitis B infection
• Kidney impairment or failure
• Confusion or altered consciousness related to raised ammonia levels
• Serious skin reactions, including toxic epidermal necrolysis and Stevens-Johnson syndrome
• Interstitial lung disease
• Bowel perforation or serious bleeding

Other General Warnings

• You have kidney or liver problems.
• You have a current or past hepatitis B infection.
• You develop persistent or severe diarrhoea, vomiting, or signs of dehydration.
• You develop confusion, unusual sleepiness, or difficulty staying alert.
• You notice any eye irritation, excess tearing, or vision changes.
• You develop a severe skin rash or blistering.
• You are due to have any vaccination.

• Take S One S One capsule exactly as prescribed by your doctor.
• Swallow the capsules with water, at least 1 hour before or 1 hour after a meal.
• Your doctor will usually also prescribe anti-sickness and anti-diarrhoeal medicines to have available at home.
• If you vomit after taking a dose, do not take a replacement dose.
• Do not increase your dose again once it has been reduced, unless your doctor specifically advises this.

• Store as directed on the product labelling.
• Keep out of the reach of children and pets.
• Wash your hands after handling the capsules.
• This is a hazardous cytotoxic medicine; return any unused or expired capsules to your pharmacy for safe disposal.

• Stay well hydrated throughout treatment, and contact your doctor promptly if you develop diarrhoea, especially if it is frequent or occurs at night.
• If you develop a fever or symptoms of infection, contact your doctor immediately. Do not stop treatment unless your doctor advises you to do so.
• Contact your doctor promptly if vomiting is persistent or you are unable to keep fluids down.
• Report any eye irritation, excess tearing, or vision changes to your doctor.
• Never take the antiviral medicine brivudine while on this treatment or during the required interval before starting treatment.

Overdose

• There is no known antidote for overdose with this medicine.
• Reported symptoms of overdose include nausea, vomiting, diarrhoea, mouth sores, gastrointestinal irritation, bleeding, and severe suppression of bone marrow function.
• If an overdose is suspected, seek emergency medical attention immediately.

Missed a Dose

Interactions with other medicines

• Brivudine (an antiviral medicine used for shingles): must never be taken with or shortly before this medicine, as the combination may cause fatal toxicity; a waiting period is required between the two.
• Other fluoropyrimidine medicines (such as capecitabine or fluorouracil): must not be combined with this medicine, as it increases the risk of severe toxicity.
• Coumarin-derivative blood thinners (such as warfarin): this medicine can increase their blood-thinning effect, so your blood clotting tests will need closer monitoring.
• Phenytoin (used for seizures): this medicine can raise phenytoin levels in the blood, so your doctor will need to monitor you more closely.
• Folinic acid, metronidazole, methotrexate, clozapine, and cimetidine: may increase the toxicity of this medicine; your doctor will use caution if these are needed together.
• Allopurinol (used for gout): may reduce the effectiveness of fluoropyrimidine treatment and should generally be avoided unless specifically advised by your doctor.
• Tell your doctor about all other prescription medicines, over-the-counter medicines, and herbal supplements you are taking.

Interactions with food items