Rifabutin 150 Mg Tablet 10

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Rifabutin 150 MG Description

Rifabutin 150 mg tablet is an antibiotic used with other medicines to help prevent or slow down the spread of Mycobacterium Avium Complex (MAC) disease and tuberculosis (TB) in HIV-positive persons.

It is also used to treat H pylori infections that cause gastric ulcers. Rifabutin 150 mg tablet is also known as Rifamycin, an antimycobacterial medicine. The mode of action of Rifabutin 150 mg tablet is by killing the Mycobacteria species of bacteria. Rifabutin is a reserved antibiotic used specifically for the aforementioned conditions, as its undue use may develop resistance to treatment with this medicine. The directions for use of Rifabutin 150 mg tablets should be strictly followed. Side effects of Rifabutin 150 mg tablets include rashes, low haemoglobin, nausea, fever, heartburn/gastritis, loose stools, etc. These usually go away in a few days as the body adjusts to the medicines. The treating doctor must know the affected person’s medical history and all other medications being taken. This is so they can check for any potential interaction issues. Rifabutin 150 mg tablets give an orange-red colour to urine and all body fluids, including tears.

Product Summary

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Contains	Rifabutin(150.0 Mg)
Uses	Pulmonary TB (only in patients co-infected with HIV; it should never be used as a substitute to Rifampicin in TB patients without HIV co-infection); H Pylori gastritis infection
Side effects	Nausea, Burping, Loose stools, Heartburn, Abdominal pain, Gastritis, Rash, Altered taste, Muscle pain
Therapy	ANTI-TUBERCULAR

Check more medicines with composition as Rifabutin(150.0 Mg)

Precautions and Warnings

Uses of Rifabutin 150 MG

According to CDSCO guidelines, Rifabutin 150 mg tablets are used for:
Treatment of Pulmonary TB, only in patients co-infected with HIV. It should never be used as a substitute for Rifampicin in TB patients without HIV co-infection
Prevention of Mycobacterium Avium Complex (MAC) in persons co-infected with HIV
H Pylori gastritis infection

Contraindications of Rifabutin 150 MG

Do not take Rifabutin 150 mg tablets or use caution:
If you have chronic kidney disease; dose adjustment may be required
If you have severe liver disease; dose adjustment may be required
If you have an allergy to rifabutin, rifampin, rifaximin, other similar medicines; this medication is contraindicated in such cases

Side effects of Rifabutin 150 MG

Common side effects of Rifabutin 150 mg tablets include:
Nausea
Loose stools
Heartburn
Abdominal pain
Gastritis
Rash
Altered taste
Muscle pain
Discoloration of urine
Discoloration of skin

Precautions and Warnings of Rifabutin 150 MG

Pregnancy

Can I take Rifabutin 150 mg tablets during pregnancy?

Limited human studies have not shown Rifabutin 150 mg tablets to harm the developing foetus. But, it cannot be concluded because animal data shows foetal anomalies. You need to confirm this with your doctor.

Breast Feeding

Can I take Rifabutin 150 mg tablets while breastfeeding?

Rifabutin 150 mg tablets are safe to use while breastfeeding. It is not known to cause harm to the baby. However, consult your doctor before taking any medicine while nursing your child.

Driving

Can I drive if I have taken a Rifabutin 150 mg tablet?

Yes. Rifabutin 150 mg tablets do not affect your ability to drive.

Alcohol

Can I consume alcohol with Rifabutin 150 mg tablets?

No interaction is known of Rifabutin 150 mg tablet with alcohol. However, consult your doctor if you wish to drink alcohol while on treatment with Rifabutin 150 mg tablets.

Other General Warnings

Talk to your doctor if

You have an allergy to rifabutin, rifampicin, rifaximin, other medicines, or any other ingredient in Rifabutin 150 mg tablets.
You have liver, heart, or kidney disease.
You take hormonal contraceptive pills or instruments; Rifabutin may interfere with the action of hormonal contraceptives. Talk to your doctor if you plan to conceive, become pregnant, or are breastfee...
Read more
You notice a change in the colour of your urine (orange-red), skin colour, or the colour of other body fluids.
You wear soft contact lenses.

Mode of Action of Rifabutin 150 MG

How Does It Work?

Rifabutin 150 mg tablet is an antibiotic that kills and limits the growth of bacterial infection. It inhibits the DNA-dependent RNA polymerase enzyme in bacteria, which leads to decreased RNA synthesi...

Directions for Use of Rifabutin 150 MG

Take Rifabutin 150 mg tablets exactly as advised by your doctor.
Do not exceed the dosage, even if you cannot notice the effects of this medicine.
Take Rifabutin 150 mg tablets with a glass of water.
Take this medicine with food to minimise the side effects of nausea or vomiting.
Do not take Rifabutin 150 mg tablets with other medications without informing your doctor.
Do not consume this medicine if its packaging is broken.

Interactions of Rifabutin 150 MG

Interactions with other medicines

Rifabutin 150 mg tablets can interact with many medicines and cause adverse side effects. It is advised to inform the doctor of all medication being taken to be checked for possible interaction issues...
Read more
Antifungals like ketoconazole, itraconazole, fluconazole, and voriconazole
Antibiotics such as Ciprofloxacin
Antivirals such as Delavirdine
Macrolide antibiotics like clarithromycin
Hormonal contraceptives

Interactions with food items

Avoid taking Rifabutin 150 mg tablets with acidic food and beverages. These include sugar, dairy products, fish, fresh meat, sodas, processed foods, and sweetened beverages.

Storage and disposal of Rifabutin 150 MG

Store Rifabutin 150 mg tablets at room temperature, away from wet surfaces, direct sunlight, and humidity. Keep away from children and pets. Check the expiration date before taking the tablets. Dispos...

Dosage of Rifabutin 150 MG

Overdose

Rifabutin 150 mg tablet overdose can cause severe reactions. If the affected person has collapsed, has breathing difficulty, or is unconscious, rush them to a nearby hospital for emergency treatment.

Missed a Dose

If you have missed a dose of Rifabutin 150 mg tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue wi...

Content Details

WRITTEN BY

Dr. Divya Rohra

MBBS

REVIEWED BY

Dr. Jagruti Jain

M.B.B.S., M.D., D.N.B., General Medicine

Frequently Asked Questions (FAQs)

Q: Is Rifabutin 150 mg tablet the same as Rifampin?

A: Rifabutin 150 mg tablet is a longer-acting ant-TB antibiotic, having up to 35 hours of half-life. Rifampin, on the other hand, has a half-life of 3.5 hours. Both are used against the same bacteria and disease, but Rifabutin is more potent. Also, since TB bacteria have become resistant to Rifampin, Rifabutin is used instead.

Q: After using Rifabutin 150 mg tablets for four weeks, I am observing a change in the colour of my urine. It is red. Is this a result of bleeding?

A: This is not something you should be concerned about, as long as you have no other symptoms. Rifabutin 150 mg tablets cause an orange-red discolouration of the skin and body fluids like urine and tears. It is a side effect of this medicine and has nothing to do with blood loss or hematuria.

Q: Can I stop Rifabutin 150 mg tablets once I feel better?

A: Do not stop taking this medicine even if you feel better. Anti-TB treatment takes 6-12 months to complete. Whether or not you have symptoms during this time, it is vital to finish the course of treatment. If you stop in between, the bacteria may become resistant to the antibiotic, and the disease will become harder to treat.

References

Product Details

Brand

RIFABUTIN

Country of Origin

India

Manufacturer Details

Last Updated on: 30 Mar 2022 | 10:25 AM (IST)

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