Placida Tablet
10 Tablet(s) in StripWe do not sell this product
Made by
MANKIND PHARMACEUTICALS LTD
Dosage
TABLET
Expiry
Product Summary
| Salt Content | Melitracen(10.0 Mg)+Flupentixol / Flupenthixol(0.5 Mg) |
| Uses | Treatment of mild to moderate depression and anxiety |
| Therapy | Anti-depressant |
| Side effects | Drowsiness, dry mouth, constipation, vomiting, abdominal pain, nausea, flatulence, difficulty in breathing, myalgia, muscle rigidity, urinary retention, increased appetite, weight gain, and decreased libido. |
Assurance
available
Regulated
Medical Description
Placida is a medication that contains a combination of two drugs, Flupentixol (0.5mg) and Melitracen (10mg), primarily used in the treatment of depression. Flupentixol belongs to a group of drugs called antipsychotics, whereas Melitracen is a tricyclic antidepressant. This combination at this particular dosage is used in the management of mild to moderate depression and anxiety.
Flupentixol is a first-generation antipsychotics. This drug works by blocking dopamine and serotonin receptors in the brain. At low doses (0.5- 3mg), this drug shows anti-depressant effects. It has also shown to decrease thoughts of self-harm in users who have such tendencies in depression.
Melitracen is a tricyclic antidepressant that acts on multiple brain pathways to increase levels of certain neurotransmitters, effectively decreasing the user’s symptoms. It acts by preventing the re-uptake of both serotonin as well as nor-adrenaline. It has both anti-depressant and anti-anxiety properties.
Placida should be taken as per the physician's recommendation only. It is best to take the tablet at the same time every day as this ensures the best action of the medication, decreasing the chances of relapse of symptoms significantly. It is also recommended to complete the entire course of the medication as prescribed.
Uses
- Mild to moderate depression
- Anxiety
- Asthenia (weakness)
Contraindications
- Patients with the following problems must refrain from consuming this medicine:
- Hypersensitivity
- Circulatory collapse
- Decreased level of consciousness due to any cause
- Coma
- Electroconvulsive therapy or severe depression requiring hospitalization
- Not recommended for use in manic or excited states.
- Patients with porphyrias (a kind of blood disorder where there is accumulation of a specific protein that is a byproduct of red blood cell metabolism)
- Epilepsy
- Patients with prolactin dependent tumors or breast cancer
- Parkinson's disease
- Narrow angle glaucoma
- Patients with prostate enlargement
- Thyroid disorders
- Cardiac disease or arrhythmias
- Severe respiratory disease
- Kidney failure
- Myasthenia gravis
- Pheochromocytoma
Side effects
- Drowsiness
- Dry mouth
- Increased appetite
- Weight gain
- Constipation
- Vomiting
- Acid regurgitation/ acid peptic disease
- Diarrhea
- Abdominal pain
- Nausea
- Flatulence
- Extra pyramidal effects, especially in the initial phase of the treatment, such as rigidity, muscle spasms, slowness of movements, tremors, irregular movements etc.
- Increased heart rate
- Palpitations
- Prolonged QT interval in ECG resulting in cardiac disorders like arrhythmias
- Hypotension (fall in blood pressure)
- Decrease in platelet, white blood cell counts
- Difficulty in breathing (dyspnea)
- Myalgia
- Muscle rigidity
- Retention of urine
- Poor control of blood sugar levels in case of diabetics
- Insomnia
- Decreased libido
- This drug is not recommended during pregnancy and breastfeeding.
- Close monitoring for changes in behavior, suicidal thoughts or clinical worsening during the initial part of the treatment is recommended. Withdrawal should be gradual
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Do not consume alcohol while on this medication.
- Driving and use of heavy machinery while on this medication is not recommended.
- Give your doctor details about any other medicine you are taking at the time of prescribing Placida.
Directions for Use
- This medication should be taken as prescribed by the treating physician.
- It is recommended to take this medication on a regular schedule, i.e., at the same time every day for optimal pharmacological effects of this medication.
- Swallow this medication as a whole. Do not crush, chew or break this tablet.
- It is recommended to finish the full course of this medication as prescribed by your treating doctor. Abrupt stoppage of the drug can cause withdrawal side effects. Consult your doctor before stopping this medication.
- It can be taken with or without food.
Storage and disposal
Keep in a cool and dry place.
Storage under 30’C
Dosage
Overdose
Overdose is characterized by extreme agitation, excitement, confusion, sleepiness, coma, convulsions, and hyperthermia or hypothermia, frequently succeeded by sedation. Extrapyramidal symptoms or respiratory and circulatory collapse may be observed. QT prolongation, ECG changes, cardiac arrest, and ventricular arrhythmias have been reported with large doses of Flupentixol. In case of overdose, symptomatic treatment should be initiated with airway management. In case of a suspected overdose, immediately rush the patient to the nearest medical centre for emergency management as it can be life threatening.
Missed a Dose
If you miss a dose of this tablet, it is advised to take it as soon as possible. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose of the tablet.
Mode of Action
How Does It Work?
Flupentixol belongs to a class of drugs known as first-generation antipsychotics. At lower doses (between 0.5mg to 3mg), it is known to exert antidepressant effects, particularly in combination with Melitracen. It acts on two chemicals that act as signals in the brain, otherwise known as neurotransmitters. The neurotransmitters involved here are dopamine and serotonin. Flupentixol effectively blocks the dopamine and serotonin receptors, thus causing antidepressant actions on the brain.
Melitracen is a tricyclic antidepressant (TCA). The exact mechanism of action of Melitracen is still unclear, but it is hypothesized to behave like other TCAs such as Amitriptyline and Imipramine. It works on multiple brain pathways to increase levels of certain neurotransmitters, effectively decreasing the user’s presenting symptoms. The neurotransmitters involved here include serotonin and nor-adrenaline. It also produces anti-anxiety effects in users.
This medication may be required to be taken over a long duration for maximum efficacy. Abrupt stoppage of this medication may produce withdrawal symptoms.
Interactions
Interactions with other medicines
- This medication is known to potentiate the effects of general anesthetics.
- This medication should not be mixed with anticoagulants, such as heparin, warfarin, rivaroxaban, dabigatran, apixaban etc as it may increase their effects beyond therapeutic benefits.
- This medication can prolong the action of neuromuscular blockers, such as vecuronium, rocuronium, succinylcholine.
- May increase anticholinergic effects of drugs with anticholinergic activity and atropine. Anticholinergic effects include dry mouth, constipation, urinary retention, bowel obstruction, dilated pupils, blurred vision, increased heart rate, and decreased sweating.
- May increase risk of neurotoxicity when consumed with lithium or sibutramine.
- Avoid concurrent usage with drugs that cause QT prolongation or cardiac arrhythmias.
- Do not mix this medication with other tricyclic antidepressants as it may affect metabolism.
Interactions with food items
- It is known to cause an increase in appetite and weight gain, and is thus recommended to consume a healthy, balanced diet.
Frequently Asked Questions (FAQs)
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Manufacturer Details
Brand:PLACIDA
Manufacturer Name:MANKIND PHARMACEUTICALS LTD
Address:J.K.Print Packs (Pharma Division), C-14 To 17, Sara Industrial Estate Ltd. Vill Rampur, Selaqui, Distt. Dehradun 248197, Uttarakhand
Country of Origin:India
Vendor Details
Fulfillment Information: Placida Strip Of 10 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
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Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
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