Ixempra 15Mg Injection

• In combination with capecitabine, for certain patients with metastatic or locally advanced breast cancer resistant to an anthracycline and a taxane, or whose cancer is taxane-resistant when further anthracycline therapy is not appropriate.
• As a single agent, for certain patients with metastatic or locally advanced breast cancer whose cancer has progressed after treatment with an anthracycline, a taxane, and capecitabine.

• If you have a known hypersensitivity to ixabepilone or any of its ingredients, including severe hypersensitivity to Cremophor EL or related compounds.
• If your baseline neutrophil count or platelet count is below the required level before starting a treatment cycle.
• When used in combination with capecitabine: in patients with significant hepatic impairment or markedly elevated liver enzymes/bilirubin, according to the prescribing information.

• Low white blood cell count (neutropenia and leukopenia), anaemia, low platelet count
• Numbness, tingling, or pain in the hands and feet (peripheral sensory neuropathy)
• Fatigue
• Muscle and joint pain
• Hair loss
• Nausea, vomiting, mouth sores, diarrhoea

• Loss of appetite
• Abdominal pain
• Changes to the nails
• Constipation
• Headache
• Infections

• Severe neutropenia with fever, and neutropenia-related infections that can be fatal
• Severe allergic reactions, including anaphylaxis
• Heart problems, including reduced heart function or reduced blood flow to the heart
• Severe hand-foot syndrome
• Severe or worsening peripheral neuropathy requiring treatment to be stopped

Other General Warnings

• You have liver problems, as hepatic impairment can increase the risk of severe toxicity.
• You have heart problems or a history of heart disease.
• You have any pre-existing nerve-related condition.
• You develop worsening numbness, tingling, or weakness.
• You experience fever, chills, or other signs of infection during treatment.
• You are planning to have children,as treatment may affect fertility.

• Ixempra injection is prepared and administered only by trained healthcare professionals as an intravenous infusion in a hospital or clinic setting.
• You will receive premedication, including antihistamine medicines, before each infusion to reduce the risk of an allergic reaction.
• Keep all scheduled treatment and blood test appointments, as your doctor will closely monitor your blood counts, liver function, and nerve symptoms.

• Store the unopened product according to the manufacturer's storage instructions.
• Keep out of the reach of children and pets.
• This is a hazardous cytotoxic medicine; clinical staff manages disposal according to hospital biomedical waste protocols.

• Report any numbness, tingling, or pain in your hands or feet to your doctor, as your dose may need adjustment.
• Report fever, chills, or signs of infection to your medical team immediately.
• Watch for signs of an allergic reaction during your infusion, such as rash, flushing, or difficulty breathing, and tell your nurse straight away.
• Watch for unusual bruising or bleeding and report it to your doctor.
• Inform all your healthcare providers that you are receiving this medication before any other medical or dental procedure.

Missed a Dose

Overdose

• There is no specific antidote for ixabepilone overdose. Overdoses may worsen bone-marrow suppression, peripheral neuropathy, gastrointestinal symptoms, fatigue, and other toxic effects.
• If an overdose is suspected, seek emergency medical attention immediately; management is supportive.

Interactions with other medicines

• Strong inhibitors of the liver enzyme CYP3A4 (certain antifungal and antibiotic medicines): can increase the amount of ixabepilone in your body; your doctor may need to adjust your dose or avoid the combination.
• Strong inducers of the liver enzyme CYP3A4: can reduce how well this medicine works.
• Capecitabine: when prescribed together, your doctor will monitor you for the combined toxicity of both medicines.
• Tell your doctor about all other prescription medicines, over-the-counter medicines, and herbal supplements you are taking.

Interactions with food items