express delivery
Express delivery to
Select Pincode
Search for Medicine and Healthcare items
Search

Isolazine Tablet

15 Tablet(s) in Strip

MRP ₹237.70

₹178.27

25% OFF

₹11.88/tablet (Inclusive of all taxes)
30 days return policy Read More
✱Offer applicable on order above ₹1000
  • Isolazine Tablet
  • Isolazine Tablet
  • Isolazine Tablet
  • Isolazine Tablet

Made by

LUPIN

Dosage

TABLET

Expiry

Order on Whatsapp

Product Summary

Uses
Heart failure
Therapy
Drugs for congestive heart failure
Side effects
Headache, dizziness, nausea, fatigue
Salt Content
Hydralazine(37.5 Mg)+Isosorbide Dinitrate(20.0 Mg)
3 Step Quality
Assurance
Cash on delivery
available
NPPA
Regulated

Medical Description

Isolazine Tablet is used in the treatment of heart failure, added to standard therapy to relieve symptoms and improve outcomes. It is especially useful for people who cannot take the usual first-line medicines because of kidney impairment or raised potassium.

It contains isosorbide dinitrate and hydralazine, which reduce the workload of a failing heart from two directions. The nitrate widens veins so less blood returns to the heart, while hydralazine widens arteries so the heart pumps against less resistance.

Take it exactly as prescribed, spread through the day, and never stop suddenly, as fluid can build up and chest pain may be provoked. Weigh yourself each morning and report a gain of two kilograms or more over two to three days.

Headache and dizziness on standing are common, arising directly from the widening of blood vessels, and usually ease over the first weeks. Seek advice for joint pain with fever and rash, which may indicate a rare lupus-like reaction to hydralazine.

Never take sildenafil, tadalafil, vardenafil or riociguat with this medicine; the combination can cause a catastrophic drop in blood pressure. Avoid alcohol, rise slowly, and tell every doctor treating you that you take a nitrate.

Some other medicines with a combination of hydralazine and isosorbide dinitrate include Nitrohart tablet, Apresol Plus tablet and Isorus tablet.

Uses

Isolazine tablet is used in the treatment of heart failure as an adjunct to standard therapy.

Contraindications

  • If you are allergic to Isolazine tablets or their other ingredients.
  • It should not be used in patients taking medicines containing sildenafil, avanafil, tadalafil or vardenafil (used for treating erectile dysfunction in men).
  • If you are taking a medicine called riociguat which is used to treat high blood pressure in the lungs (pulmonary hypertension).

Side effects

  • Headache
  • Dizziness
  • Nausea
  • Fatigue
  • Low blood pressure

Precautions and Warnings

Pregnancy

Pregnancy

Consult your doctor before taking the Isolazine tablets during pregnancy as limited information is present. Your doctor will only prescribe you this medicine if considered essential after assessing the benefits over risks.

Breast Feeding

Breast Feeding

Consult your doctor before taking the Isolazine tablets while breastfeeding as it is unknown if its components pass into the breastmilk.

Driving

Driving

It is advised not to drive if you have consumed the Isolazine tablet as you may experience dizziness after taking it.

Alcohol

Alcohol

You should avoid consuming alcohol while taking the Isolazine tablet, as it may worsen the side effects of this medicine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have heart-related problems.
  • You have severe kidney or liver problems.
  • You are having any surgery.
  • You have glaucoma (increased pressure in the eye).
  • You are undernourished.
  • You are suffering from hypothermia (a condition in which your body loses heat faster than it can produce).
  • You have suffered from bleeding in the brain.
  • You have an underactive thyroid gland.
  • You experience headache, nausea, dizziness, fainting (symptomatic hypotension).
  • You experience any abnormal sensation on your skin such as numbness and tingling.
  • You have systemic lupus erythematosus (an autoimmune disorder), this medicine may induce this condition.
  • You suffer from a deficiency of an enzyme called glucose 6 phosphate dehydrogenase.

Directions for Use

  • Take the Isolazine tablets as directed by your doctor.
  • Swallow it as a whole with water.
  • Do not chew or break the tablet.
  • To get the optimal results take it at a fixed time.

Storage and disposal

  • Store the Isolazine tablets below 30°C temperature.
  • Protect it from light and moisture.
  • Keep it out of the reach of children and pets.

Quick Tips

  • Isolazine Tablet eases the work of a failing heart by widening both the veins and the arteries.
  • Never take sildenafil, tadalafil, vardenafil or riociguat with this medicine; the combination can be fatal.
  • Tell every doctor and dentist that you take a nitrate before any new medicine is prescribed.
  • Headache is common in the first days and usually settles; paracetamol helps.
  • Stand up slowly from sitting or lying, especially in hot weather or after a bath.
  • Avoid alcohol, which adds to dizziness and the risk of falls.
  • Weigh yourself each morning and report a gain of two kilograms or more over two to three days.
  • Report joint pain with fever, rash or unexplained tiredness, which may indicate a lupus-like reaction.
  • Report tingling or numbness in the hands or feet, which may respond to vitamin B6.
  • Reduce salt and follow any fluid limit your doctor has set.
  • Never stop this medicine suddenly, even if you feel well.

Dosage

Overdose

If you have taken an excess of the Isolazine tablets and experience side effects such as headache, uneven heart rhythm then contact your doctor immediately or go to the nearest hospital.

Missed a Dose

If you have missed taking a dose of the Isolazine tablet take it as soon as possible. Skip the dose if it's already time for the next dose. Do not double the dose.

How does this medicine work?

Isolazine tablets contain isosorbide dinitrate and hydralazine which work by relaxing the blood vessels and hence make the blood flow easy.

Interactions

Interactions with other drugs

Interactions with food items

  • Isolazine Tablet may be taken with or without food, but keep the pattern consistent from day to day so the effect remains steady. Taking it with food can reduce nausea.
  • Alcohol should be avoided or kept minimal, as it adds substantially to dizziness and the risk of fainting and falls.
  • Reduce salt, which is one of the most effective dietary measures in heart failure. Limit pickles, papads, packaged snacks, processed meats and restaurant food, and avoid adding salt at the table.
  • Follow any daily fluid limit your doctor has set, and weigh yourself every morning to catch fluid retention early.
  • Rise slowly after meals, as blood pressure can dip further during digestion, particularly after a large meal.
  • If you develop tingling in the hands or feet, ask your doctor about vitamin B6, as hydralazine can interfere with it.

Frequently Asked Questions (FAQs)

Isolazine Tablet is used in the treatment of heart failure, added to standard therapy to improve symptoms and outcomes. It is particularly valuable for people who cannot tolerate the usual first-line medicines because of kidney problems or a high blood potassium level.
They unload the heart from two directions. Isosorbide dinitrate widens the veins, so less blood returns to the heart and it does not have to stretch as far to fill. Hydralazine widens the arteries, so the heart pumps against less resistance. Together they reduce the work of a weakened heart far more effectively than either alone.
This is the most important safety point with this medicine. Sildenafil, tadalafil and vardenafil, used for erectile dysfunction and pulmonary hypertension, act on the same pathway as the nitrate component. Taken together they can cause a catastrophic fall in blood pressure leading to collapse, heart attack or death. They must never be combined.
Headache is the commonest effect and comes from widening of the blood vessels in the head, exactly the same action that helps your heart. It is usually worst in the first days and settles as your body adapts. Paracetamol helps; tell your doctor if it persists or is severe.
Long-term hydralazine, especially at higher doses, can occasionally trigger an illness resembling lupus, with joint pain and swelling, persistent fever, unexplained tiredness, a rash across the cheeks and chest discomfort. It usually resolves after the medicine is stopped. Report these symptoms to your doctor promptly.
Both components relax blood vessels, so blood pools in the legs when you stand and the pressure reaching your brain briefly drops. This is most noticeable after the first doses, in hot weather, after a hot bath, or if you have had alcohol. Get up slowly and sit down again if you feel light-headed.
No. Feeling better means the medicine is working. Stopping allows fluid to build up and symptoms to return, and abruptly stopping a nitrate can provoke chest pain. Any change should be made gradually by your doctor.
It can. Hydralazine interferes with vitamin B6, which occasionally causes numbness or tingling in the hands and feet. This responds to pyridoxine supplements, so tell your doctor if you notice it rather than simply putting up with it.
Yes, this is one of the most useful things you can do in heart failure. Weigh yourself each morning after passing urine and before breakfast. A gain of two kilograms or more over two to three days usually means fluid is accumulating and should be reported.
Alcohol should be avoided or kept very limited. It widens blood vessels in its own right and adds to the drop in blood pressure, making dizziness and fainting much more likely. Heavy drinking also directly damages the heart muscle.
Mention any recent heart attack, narrowing of a heart valve, constrictive pericarditis, lupus, severe kidney or liver disease, and any nerve problems. Tell your doctor if you are pregnant or breastfeeding, and crucially list every medicine you take, including anything for erectile dysfunction.
Take it as soon as you remember, unless your next dose is nearly due, in which case skip it. Never take two doses together, as this can cause a severe fall in blood pressure. If you miss several doses, tell your doctor.

References:

Have question? Ask us!

Ask us anything about the product to understand it better

Articles

View All

Explore More at Pharmeasy

Manufacturer Details

Brand:ISOLAZINE

Manufacturer Name:LUPIN

Address:Lupin Ltd ,Epip ,Sidco Industrial Complex,Kartholi ,Bari ,Brahmana, Jammu ,J & K - 181113, India

Country of Origin:India

Vendor Details

Fulfillment Information: Isolazine 20/37.5mg Strip Of 15 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.

In Case of Any Issues Contact Us

Email Id:care@pharmeasy.in

Phone Number:7666100300

Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703

Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.

Our Payment Partners
https://assets.pharmeasy.in/web-assets/_next/icons/gpay.svghttps://assets.pharmeasy.in/web-assets/_next/icons/paytm.svghttps://assets.pharmeasy.in/web-assets/_next/icons/amazon-pay.svghttps://assets.pharmeasy.in/web-assets/_next/icons/phonepe.svghttps://assets.pharmeasy.in/web-assets/_next/icons/mobikwik.svghttps://assets.pharmeasy.in/web-assets/_next/icons/airtel-money.svghttps://assets.pharmeasy.in/web-assets/_next/icons/ola-money.svghttps://assets.pharmeasy.in/web-assets/_next/icons/maestro.svghttps://assets.pharmeasy.in/web-assets/_next/icons/mastercard.svghttps://assets.pharmeasy.in/web-assets/_next/icons/visa.svghttps://assets.pharmeasy.in/web-assets/_next/icons/rupay.svghttps://assets.pharmeasy.in/web-assets/_next/icons/diners.svg