Dukinase 25000iu Injection
Description
Dukinase injection is a medicine used to dissolve harmful blood clots in the body. The active ingredient in this medication is urokinase. It can help clear clots that block tubes (catheters) in veins or arteries, treat deep vein thrombosis (DVT) in the legs, and aid in emergencies such as large clots in the lungs (pulmonary embolism). It also helps restore blood flow when clots block arteries in the arms or legs. It works by activating a natural substance in the blood called plasminogen, which turns into plasmin. Plasmin breaks down the clot, helping to restore normal blood flow.
Dukinase injection should not be used if you are allergic to any of its ingredients or have had recent serious bleeding, surgery, stroke, or childbirth. It is also not recommended if you have uncontrolled high blood pressure, serious liver or kidney disease (unless you're on dialysis), or bleeding disorders. People with infections, certain types of tumours, or conditions that may easily cause bleeding, especially in the brain, should avoid using this medicine.
The most common side effect is bleeding, which can happen at injection sites, from the nose or gums, or in the urine. Rarely, blood clots can move to other parts of the body, including the lungs. Certain medications, such as blood thinners (warfarin, heparin), anti-inflammatory drugs (aspirin, ibuprofen), and ACE inhibitors for blood pressure, can increase the risk of bleeding or allergic reactions when taken in combination with this medication. Contrast dyes used in scans may reduce their effectiveness. This medication is given by a doctor or nurse, so it’s unlikely you’ll miss a dose or be given too much.
Store Dukinase injection below 25°C and away from sunlight. Keep it out of reach of children and discard any leftover medicine properly. It should not be used during pregnancy or breastfeeding unless clearly needed, and always under a doctor’s advice. If you’re over 75 years of age, have serious health conditions, or are on other medications, make sure to tell your doctor. You should also report any unusual bleeding or bruising right away.
Product Summary
| Offer Price | ₹1672.00 |
| You Save | ₹528.00 (24% on MRP) |
| Contains | |
| Uses | Blood clotting disorders |
| Side effects | Bleeding, nosebleeds, blood in the urine, gum bleeding |
| Therapy | THROMBOLYTIC |
Uses
- Dukinase injection is used to clear blood clots that block tubes (catheters or cannulas) placed in your veins or arteries.
- It helps treat serious blood clots in the deep veins, usually in the legs, a condition known as deep vein thrombosis (DVT).
- It is used in emergencies to treat a large blood clot in the lungs, also called a pulmonary embolism, which can be very dangerous.
- It is also used to treat blocked blood flow in the arms or legs, when a clot is cutting off circulation and may put the limb at risk of damage.
Contraindications
- If you are allergic to urokinase or any other ingredients of Dukinase injection.
- If you have active or recent serious bleeding, such as in the stomach, intestines, or brain, or if you have had major surgery, injury, or childbirth recently.
- If you have had a recent stroke or brain-related bleeding (within the last 2 months).
- If you have severe, uncontrolled high blood pressure.
- If you have serious liver or kidney problems, unless you are on dialysis.
- If you have a blood clotting disorder, a very low platelet count, or conditions such as an aneurysm or abnormal blood vessel connections.
- If you have certain serious infections or inflammations, such as pancreatitis, heart infections, or sepsis.
- If you have tumours that could easily bleed, especially in the brain.
Side effects
- Bleeding
- Nosebleeds (epistaxis) or bleeding from your gums (gingival bleeding).
- Pulmonary embolism (a blockage in the lungs).
- Blood in the urine
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have recently undergone surgery, experienced bleeding, or sustained injuries.
- You have serious heart, brain, liver, or kidney problems.
- You are elderly (especially over 75 years of age).
- You are taking blood thinners or ACE inhibitors.
- You notice bleeding or bruising, even at needle or injection sites.
Directions for Use
Storage and disposal
- Store Dukinase injection below 25°C, protect it from direct sunlight.
- Do not store above 25°C or freeze.
- Keep it out of the reach of children and pets.
- Discard the unused medicine.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Mixing Dukinase injection with 5% glucose in plastic (PVC) containers may reduce its effectiveness.
- Using blood thinners like warfarin or heparin at the same time may increase the risk of bleeding.
- Medicines that affect how platelets work such as aspirin, clopidogrel, ibuprofen, dipyridamole, or dextrans. It can also raise the risk of bleeding.
- ACE inhibitors (commonly used for high blood pressure or heart conditions) may increase the chance of a serious allergic reaction called angioedema (swelling of the face, lips, or throat).
- Contrast dyes used in imaging procedures may slow down the rate at which Dukinase injection dissolve clots.
Content Details
Ravindra Ghongade
B. Pharm
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What should I do if I experience bleeding while on Dukinase injection?
Q: Can Dukinase injection be used for chronic clot conditions?
References
- Syner-KINASE 250,000 IU Powder for Solution for Injection or Infusion [Internet]. Electronic Medicines Compendium (eMC); c2024 [cited 2025 Jun 13].
- Central Drugs Standard Control Organisation. Drugs [Internet]. New Delhi: Ministry of Health and Family Welfare, Government of India; [cited 2025 Jun 13].
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