Vildagliptin+Metformin

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Molecule Description

Metformin+Vildagliptin is a combination medicine. It is used to treat type 2 diabetes mellitus when diet, exercise and metformin or vildagliptin alone are not effective. It belongs to a class of medicines called anti-diabetics. Metformin+Vildagliptin is available in the form of a tablet. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting this medicine.

Uses

Metformin+Vildagliptin is used for the treatment of type 2 diabetes mellitus when vildagliptin or metformin alone, along with diet and exercise are ineffective in controlling your blood sugar.

Contraindications

When should one not use Vildagliptin+Metformin

If you are allergic to vildagliptin, metformin or similar medicines
If you are suffering from any heart problems
If you have any problems with your kidney or liver
If you have type 1 diabetes
If you have uncontrolled diabetes along with nausea, vomiting, diarrhoea, rapid weight loss, lactic acidosis (symptoms include stomach pain, fast or rapid breathing, sleepiness).
If you are in a state of diabetic coma due to a sudden rise or drop in blood sugar level
If you are a breastfeeding mother
If you have undergone surgery or stress
If you have a severe infection or dehydration
If you are an alcoholic or consume alcohol in excess regularly

Side effects

Common side effects of this drug are:

Headache
Tiredness
Nausea
Vomiting
Diarrhoea
Loss of appetite
Stomach pain
Constipation

Precautions and Warnings

Pregnancy

Consult a doctor before using metformin+vildagliptin during pregnancy as limited safety data is available in pregnant women.

Breast Feeding

Consult a doctor before using metformin+vildagliptin while breastfeeding as it passes into breast milk.

Driving

Avoid driving if you have taken metformin+vildagliptin as it may cause low blood sugar levels, which can impair your driving ability.Always keep sugar or chocolate with you, in case you experience low blood sugar, immediately have sugar or chocolate.

Alcohol

It is unsafe to consume alcohol with metformin+vildagliptin, thus you must avoid it.

Other General Warnings

Talk to your doctor if

You have problems with your heart, liver or kidneys
You have uncontrolled diabetes
You are suffering from some serious infections
You have an irregular diet, habit of excessive alcohol intake, intense muscular movement
You experience symptoms of lactic acidosis like vomiting, stomach pain, muscle cramps, fatigue, difficulty breathing.
You experience any symptoms like dehydration, vomiting, diarrhoea, fever
You ever had any surgery on your stomach
Metformin+Vildagliptin is not recommended for use in patients below 18 years of age.

Mode of Action

How Does It Work?

Metformin+Vildagliptin acts by decreasing the amount of glucose absorbed from the intestine, lowering the amount of sugar created by the liver, and facilitating the entry of sugar into the cells.

Interactions

Interactions with other medicines

Some medicines can affect the way metformin+vildagliptin works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
This combination should be used with caution along with medicine that enhance your blood sugar lowering effect like isocarboxazid, phenelzine, propranolol and medicines that reduce your blood sugar lowering effect like steroids, etc.
Concomitant use of metformin+vildagliptin along with medicines used to treat high blood pressure like enalapril, captopril, candesartan, losartan may increase the risk of lactic acidosis (symptoms of stomach discomfort, nausea, vomiting, loss of appetite, diarrhoea).
Medicines used to treat inflammation and pain (NSAID's) like ibuprofen and celecoxib should be used with caution.
Medicines like verapamil (used to treat blood pressure and other heart problems), rifampicin (antibiotic), Olaparib (used in cancer treatment) when used concomitantly may reduce the effects of metformin+vildagliptin.
Medicines used to treat inflammation associated with asthma and arthritis (corticosteroids) like betamethasone, prednisone should be cautiously used along with this combination.
Medicines like cimetidine, dolutegravir, ranolazine, may change the amount of metformin in your blood when taken concomitantly.