Ticagrelor

Molecule Description

Platelet inhibitor (platelets help in blood clotting).

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Ticagrelor

Heart attack
To reduce the risk of stroke in patients having a history of heart attack or chest pain
In patients who have stents inserted (i.e. to prevent blocking of the stent with a blood clot)

Contraindications of Ticagrelor

When should one not use Ticagrelor

You are allergic to Ticagrelor
You have any active bleeding currently
You have a history of intracranial bleeding or history of bleeding from ulcer in the stomach or intestine
In patients in whom aspirin is contraindicated

Side effects of Ticagrelor

Common side effects of this drug are:

Allergic reaction like fever, chills, rash, hives, breathing difficulty, swelling over your face, lips, throat
Bleeding from an unusual site (mouth, nose, rectum, vagina, gums)
Easy bruising, pinpoint rash on the skin
Easy weakness and fatigue
Red or pink urine
Diarrhea
Itching
Fainting
Blood in the stool (red or black ), cough or vomit (coffee coloured vomit)
Shortness of breath
Sudden numbness or weakness on one side of the body with problems in speech, balance and vision and excessive headache indicating of stroke (serious side effect)
Yellowing of eyes or skin, weakness, fever and anorexia (suggestive of liver problems)

Precautions and Warnings of Ticagrelor

Pregnancy

Can I take Ticagrelor during pregnancy?

It is not recommended during pregnancy.

Breast Feeding

Can I take Ticagrelor while breastfeeding?

It is unknown if Ticagrelor passes into breast milk. Consult your doctor before breastfeeding if you are on this medication.

Driving

Can I drive if I have consumed Ticagrelor?

Generally, Ticagrelor does not affect the ability to drive; if you feel confused or dizzy after taking this, do not drive.

Alcohol

Can I consume alcohol with Ticagrelor?

Alcohol should be avoided as it increases the risk of bleeding from the intestine and stomach.

Other General Warnings

Talk to your doctor if

Have any liver disease
Have any lung problem or difficulty in breathing
Had any recent bleeding or injury or surgery or dental procedure
Have an upcoming surgery
Have a high uric acid level
A sudden stoppage of medicine can increase the risk of heart attack or stroke

Mode of Action of Ticagrelor

How Does It Work?

Ticagrelor prevents the formation of a blood clot by not allowing the platelets to stick together in the blood. This prevents clot formation and blockage of essential vessels in the heart or other par...

Interactions of Ticagrelor

Interactions with other medicines

Non-Steroidal Anti-Inflammatory Drugs like Naproxen, Ibuprofen, Diclofenac
Taking medicine that contains more of Aspirin. Since Aspirin is already advised along with Ticagrelor. Consuming combination medicine that contains Aspirin can cause its overdose and result in bleedin...
Read more
Antibiotics like Clarithromycin
Antiviral medicine (Anti HIV medicine like Ritonavir and Atazanavir)
Antifungal medicine like Ketoconazole
Anti-seizure medications
Tuberculosis medicines like Rifampicin
Do not take Ticagrelor if you are already taking blood thinner medicines like Warfarin

Interactions with food items

No information is available.

Dosage of Ticagrelor

Overdose

Excess Ticagrelor ingestion may cause excessive bleeding from and inside different parts of the body. Seek emergency medical help immediately if you overdose.

Missed a Dose

Take medicine as soon as you remember. If the missed dose falls at the time of your next scheduled dose, then skip it. Do not take an extra dose to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Mansi Savla

B. Pharm, PharmD

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: When and how to consume the medicine?

You must take medicine precisely the way the physician prescribes it. Follow the instructions mentioned on the prescription label
Do not alter the dose unless recommended by your doctor. Please do not take it longer than advised
Do not take more aspirin than prescribed by your physician as this may render Ticagrelor less effective
The medicine can be taken with or without a meal but preferably at the same time daily
Do not discontinue taking this medicine without informing your doctor, even if you have signs of bleeding
A sudden stoppage of medicine can increase the risk of heart attack or stroke

Q: What else should I avoid while taking Ticagrelor?

A: Avoid activities that can result in injury and bleeding, e.g. rigorous exercise and take extra care while brushing your teeth, shaving, etc.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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