Tacrolimus

Molecule Description

Tacrolimus is an immunosuppressant. It is used to control your body’s immune re

sponse, enabling your body to accept the transplanted organ.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Tacrolimus

This medicine is used to prevent organ rejection in certain patients following liver, kidney or heart transplant.

Contraindications of Tacrolimus

When should one not use Tacrolimus

If you are allergic to Tacrolimus
If you are allergic to Sirolimus or any Macrolide-antibiotic (e.g. Erythromycin, Clarithromycin)

Side effects of Tacrolimus

Common side effects of this drug are:

Loose motion, nausea
Increased blood sugar, diabetes mellitus, increased potassium in the blood
Sleeping difficulties
Headache
Increase in blood pressure
Kidney problems
Reduction in blood cell counts (platelets, red or white blood cells), increase in white blood cell counts, changes in red blood cell counts
Anxiety symptoms, confusion and disorientation, depression, mood changes, hallucination, mental disorders, nightmare
Blindness, deafness (rare)
Breathlessness (rare)
Fits, disturbances in consciousness, tingling and numbness in the hands and feet, dizziness, impaired writing ability
Blurred vision
Ringing sound in your ears
Faster heartbeat
Small bleedings from the skin due to blood clots (rare)
Increased muscle stiffness (rare)

Precautions and Warnings of Tacrolimus

Pregnancy

Can I take Tacrolimus during pregnancy?

There is no sufficient data to prove this medicine’s safety in human pregnancy. Do not use this medicine in pregnancy without a physician’s advice.

Breast Feeding

Can I take Tacrolimus while breastfeeding?

This medicine passes into breast milk. This may harm a nursing baby, it is not recommended to use during breastfeeding.

Driving

Can I drive if I have consumed Tacrolimus?

This medicine may cause drowsiness. Do not drive unless you feel well.

Alcohol

Can I consume alcohol with Tacrolimus?

Too much intake of alcohol while taking this medicine has to be avoided as it can lead to excessive drowsiness.

Other General Warnings

Talk to your doctor if

If you have liver problems
If you have stomach pain with chills, fever, nausea or vomiting
If you have heart disease
Stopping your treatment with Tacrolimus may increase the chances of rejection of your transplanted organ
Do not stop your medication without your doctor’s permission

Mode of Action of Tacrolimus

How Does It Work?

Tacrolimus is an immunosuppressant. In organ transplant patients, it works by suppressing your body’s immune response, which helps your body to accept the new organ.

Interactions of Tacrolimus

Interactions with other medicines

Antifungal medicines like Ketoconazole, Fluconazole, Itraconazole, Voriconazole, Clotrimazole and Isavuconazole and antibiotics like Erythromycin, Clarithromycin and Rifampicin
Medicines used in HIV/ AIDS (e.g. Ritonavir, Nelfinavir, Saquinavir)
Nilotinib and Imatinib (used to treat certain cancers)
Mycophenolic acid which is used to suppress the immune system to prevent organ transplant rejection
Medicines for stomach ulcer and acid reflux (e.g. Omeprazole, Lansoprazole or Cimetidine)
Medicines used to treat nausea and vomiting (e.g. Metoclopramide)
Ibuprofen (used to treat fever, pain), Amphotericin B (used to treat bacterial infections) or antivirals (used to treat viral infections e.g. Aciclovir)

Interactions with food items

This medicine has food interactions with grapefruit juice. Avoid grapefruit (also as juice) while on treatment with Tacrolimus, since it can affect its levels in the blood and effectiveness.

Dosage of Tacrolimus

Overdose

Seek emergency medical attention if you suspect overdose. Overdose may be associated with nausea, tremors, elevated liver enzyme levels and kidney damage.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is almsot time for your next dose, skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Ravi Kakarla

MBBS, MBA

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with my healthcare expert before taking this medicine?

A: You should not use this medicine if you are allergic to Tacrolimus, tell about the list of medications you are using. Discuss the benefits and risks of using this medicine.

Q: When and how to consume medicine?

A: Take this medicine with or without food. Take this medicine as your doctor prescribed you.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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