Sitagliptin+Metformin Hydrochloride
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Molecule Summary
| Uses | Type 2 Diabetes mellitus |
| Therapy | Anti-Diabetic |
| Side Effects | Nausea, vomiting, stomach pain, diarrhoea, constipation, flatulence, low blood sugar, runny nose, headache, sore throat |
Medicines
available
19k pincodes
Molecule Description
Sitagliptin+Metformin Hydrochloride is used to control high blood sugar in patients with type 2 diabetes mellitus. Along with a healthy diet and regular exercise, it is a combination medicine containing sitagliptin and metformin. Sitagliptin+Metformin Hydrochloride works by increasing insulin production and restoring the body's natural response to insulin.
Sitagliptin+Metformin Hydrochloride should be taken as directed by the doctor and in the doses and duration prescribed. Please do not modify the dose or stop it before the prescribed duration, even if you feel better.
Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. Before starting this medicine, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding, about all the medicines and supplements you take and about all the conditions or diseases you suffer from.
Uses
Sitagliptin+Metformin Hydrochloride is used to control high blood sugar in patients having type 2 diabetes mellitus, along with a healthy diet and regular exercise.
Contraindications
When should one not use Sitagliptin+Metformin Hydrochloride
- If you are allergic to sitagliptin, metformin or any other ingredients of Sitagliptin+Metformin Hydrochloride.
- If you have severe kidney or liver disease.
- If your diabetes is not under control and you also have high blood sugar, nausea, vomiting, loose motions, rapid loss of weight, pain in the stomach, breathing difficulty, sleepiness, etc.
- If you have dehydration or you have the presence of severe infection.
- If you are going to have an x-ray or scan in which dye is injected into your blood.
- If you have a recent history of a heart attack.
- If you are a heavy alcohol drinker.
- If you are a lactating mother.
Side effects
Common side effects of this drug are:
- Nausea
- Vomiting
- Stomach pain
- Diarrhoea
- Constipation
- Flatulence (gas)
- Low blood sugar
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a skin blister after taking this medicine.
- You have a fever, vomiting, loose motion, heat exposure, and less fluid intake.
- You have vomiting, pain in the stomach, breathing difficulty, tiredness, muscle cramps, decreased body temperature, and decreased heartbeat after taking this medicine.
- You have low blood sugar after taking other anti-diabetic medicines along with this medicine.
- You have type 1 diabetes mellitus.
- You are undergoing any surgery.
- Your doctor tells you that you have increased triglyceride levels in your blood and you have gallstones.
Mode of Action
How Does It Work?
Sitagliptin works by increasing insulin production by the body after a meal and decreasing sugar production by the body. Metformin works by restoring the natural response of the body to insulin and decreasing sugar production by the body.
Interactions
Interactions with other medicines
- Some medicines can affect how Sitagliptin+Metformin Hydrochloride works, or this medicine itself can reduce the effectiveness of other medicines simultaneously.
- Tell your doctor about all the medicines, supplements, or herbs you are taking to avoid any possible interaction.
- Especially if you are taking other antidiabetic medicines.
Interactions with food items
Sitagliptin+Metformin Hydrochloride should be taken with food to avoid stomach upset if taken on an empty stomach. There are no known food or beverage interactions known with Sitagliptin+Metformin Hydrochloride.
Dosage
Overdose
Symptoms of overdose include severe nausea or vomiting, pain in the stomach, muscle cramps, rapid breathing. If you have taken too much of this medicine then contact your doctor or reach out to the nearest hospital immediately.
Missed a Dose
If you have missed taking any dose of this medicine then take it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule.
Frequently Asked Questions (FAQs)
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References:
- Sitagliptin+Metformin Hydrochloride film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 5th Jun 2026]
- Sitagliptin+Metformin Hydrochloride film-coated tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 5th Jun 2026]
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 14219, Metformin Hydrochloride. 2025 [cited 5th Jun 2026]
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