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Sitagliptin+Metformin Hydrochloride

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Molecule Summary

Uses
Type 2 Diabetes mellitus
Therapy
Anti-Diabetic
Side Effects
Nausea, vomiting, stomach pain, diarrhoea, constipation, flatulence, low blood sugar, runny nose, headache, sore throat
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Molecule Description

Sitagliptin+Metformin Hydrochloride is used to control high blood sugar in patients with type 2 diabetes mellitus. Along with a healthy diet and regular exercise, it is a combination medicine containing sitagliptin and metformin. Sitagliptin+Metformin Hydrochloride works by increasing insulin production and restoring the body's natural response to insulin. Sitagliptin+Metformin Hydrochloride should be taken as directed by the doctor and in the doses and duration prescribed. Please do not modify the dose or stop it before the prescribed duration, even if you feel better. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. Before starting this medicine, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding, about all the medicines and supplements you take and about all the conditions or diseases you suffer from.

Uses

Sitagliptin+Metformin Hydrochloride is used to control high blood sugar in patients having type 2 diabetes mellitus, along with a healthy diet and regular exercise.

Contraindications

When should one not use Sitagliptin+Metformin Hydrochloride

  • If you are allergic to sitagliptin, metformin or any other ingredients of Sitagliptin+Metformin Hydrochloride.
  • If you have severe kidney or liver disease.
  • If your diabetes is not under control and you also have high blood sugar, nausea, vomiting, loose motions, rapid loss of weight, pain in the stomach, breathing difficulty, sleepiness, etc.
  • If you have dehydration or you have the presence of severe infection.
  • If you are going to have an x-ray or scan in which dye is injected into your blood.
  • If you have a recent history of a heart attack.
  • If you are a heavy alcohol drinker.
  • If you are a lactating mother.

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Constipation
  • Flatulence (gas)
  • Low blood sugar

Precautions and Warnings

Pregnancy

Pregnancy

Sitagliptin+Metformin Hydrochloride should not be taken while pregnant. If a patient wishes to become pregnant or if a pregnancy occurs, treatment should be stopped immediately.

Breast Feeding

Breast Feeding

A component of this medicine can pass through breastmilk and can cause harm to the breastfed baby if taken by lactating mother. This medicine should not be taken by lactating mother.

Driving

Driving

This medicine can cause dizziness or sleepiness. Avoid driving if you have dizziness or sleepiness after taking this medicine.

Alcohol

Alcohol

Avoid consuming alcohol with Sitagliptin+Metformin Hydrochloride as it may lead to 'lactic acidosis'. This may cause symptoms such as vomiting, stomach pain, fatigue, breathing difficulty, muscle cramps, decrease body temperature, reduced heartbeats.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a skin blister after taking this medicine.
  • You have a fever, vomiting, loose motion, heat exposure, and less fluid intake.
  • You have vomiting, pain in the stomach, breathing difficulty, tiredness, muscle cramps, decreased body temperature, and decreased heartbeat after taking this medicine.
  • You have low blood sugar after taking other anti-diabetic medicines along with this medicine.
  • You have type 1 diabetes mellitus.
  • You are undergoing any surgery.
  • Your doctor tells you that you have increased triglyceride levels in your blood and you have gallstones.

Mode of Action

How Does It Work?

Sitagliptin works by increasing insulin production by the body after a meal and decreasing sugar production by the body. Metformin works by restoring the natural response of the body to insulin and decreasing sugar production by the body.

Interactions

Interactions with other medicines

  • Some medicines can affect how Sitagliptin+Metformin Hydrochloride works, or this medicine itself can reduce the effectiveness of other medicines simultaneously.
  • Tell your doctor about all the medicines, supplements, or herbs you are taking to avoid any possible interaction.
  • Especially if you are taking other antidiabetic medicines.

Interactions with food items

Sitagliptin+Metformin Hydrochloride should be taken with food to avoid stomach upset if taken on an empty stomach. There are no known food or beverage interactions known with Sitagliptin+Metformin Hydrochloride.

Dosage

Overdose

Symptoms of overdose include severe nausea or vomiting, pain in the stomach, muscle cramps, rapid breathing. If you have taken too much of this medicine then contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you have missed taking any dose of this medicine then take it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule.

Frequently Asked Questions (FAQs)

Sitagliptin+Metformin Hydrochloride should be taken with food to avoid stomach upset if taken on an empty stomach. Take this medicine as prescribed by your doctor.

No, do not take crushed Sitagliptin+Metformin Hydrochloride. It should be taken as directed by the doctor. Do not crush or chew it.

Sitagliptin+Metformin Hydrochloride usually does not cause low blood sugar. It can cause low blood sugar if taken along with other antidiabetic medicines if you are taking low-calorie food or doing heavy exercise. Symptoms of low blood sugar include blurring of vision, sudden sweating, shaking, increased heartbeat, hunger, dizziness, or tingling sensation in your hands or feet. Consult your doctor if you have low blood sugar while taking this medicine.

If you have low blood sugar after taking Sitagliptin+Metformin Hydrochloride with other anti-diabetic medicines, you should eat sugar, honey, or candy, or drink fruit juice or non-diet soda to increase your blood sugar rapidly. Consult your doctor immediately if you have blurring of vision, sudden sweating, shaking, increased heartbeat, hunger, dizziness etc after taking this medicine or other anti-diabetic medicines.

You can take Sitagliptin+Metformin Hydrochloride at any time of the day, before, or after meals, as told by the doctor. But it's necessary to take it at the usual time every day for the best results.

The composition of Sitagliptin+Metformin Hydrochloride includes sitagliptin and metformin.

Nausea, runny nose, headache, sore throat and flatulence are a few side effects that can be seen during the treatment with Sitagliptin+Metformin Hydrochloride. However, these symptoms are usually mild and resolve on their own.

Sitagliptin+Metformin Hydrochloride is associated with a rare risk of lactic acidosis, particularly in patients with impaired kidney function, uncontrolled diabetes, serious infections, prolonged fasting, excessive alcohol consumption, dehydration, liver problems, or conditions that limit oxygen supply. If any of these factors apply to you, consult your doctor right away for proper guidance.

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