Sirolimus

Uses	Preventing rejection of transplanted kidney, sporadic lymphangioleiomyomatosis
Therapy	Immunosuppressant
Side Effects	Pain, headache, high blood pressure, joint pain, acne, urinary tract infection

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Molecule Description

Sirolimus is an immunosuppressant used to prevent rejection of transplanted kidney(s) by your body. It is used to treat a rare systemic disease that mainly affects females of childbearing age, called sporadic lymphangioleiomyomatosis, presenting with moderate lung disease.

Uses

To prevent rejection of transplanted kidney(s)
To treat sporadic lymphangioleiomyomatosis presenting with moderate lung disease

Contraindications

When should one not use Sirolimus

Allergy to sirolimus or any other components of the medicine

Side effects

Common side effects of this drug are:

Pain
Headache
High blood pressure
Joint pain
Acne
Urinary tract infection

Precautions and Warnings

Pregnancy

This medication should not be taken during pregnancy unless necessary, kindly inform your doctor in case you are pregnant.

Breast Feeding

You need to consult with your doctor before the use of this medicine in case you are currently breastfeeding.

Driving

No data suggesting the impact of this medicine on driving ability is available, consult your doctor for any concerns.

Alcohol

It is not known whether this medicine has interactions with alcoholic beverages. Consult your doctor for more information.

Other General Warnings

Talk to your doctor if

You are suffering from liver diseases
You are a patient with a high risk of kidney rejection
You are a patient with a body mass index higher than 30 kg/m2
You are suffering from allergy to Sirolimus or any other components of the medicine
You are on any other vitamins, supplements or medicines

Mode of Action

How Does It Work?

Sirolimus is an immunosuppressant. The medicine acts by reducing the activity of the body's immune system, which helps prevent rejection of the transplanted organ.

Interactions

Interactions with other medicines

Rifampin: Can cause decreased levels of sirolimus
Ketoconazole: Has an effect on the absorption of sirolimus in the body
Voriconazole: Co-administration can cause elevated sirolimus levels
Diltiazem: May cause increased levels of sirolimus in the body
Verapamil: Simultaneous use can affect both medicine levels (verapamil and sirolimus)
Ciclosporin: Increased levels of sirolimus seen after simultaneous use
Erythromycin: Increased absorption was noticed of both medicines (erythromycin and sirolimus) after simultaneous use

Interactions with food items

Grapefruit juice: Can lead to increased sirolimus levels in the body

Dosage

Overdose

Do not take more Sirolimus than the prescribed dose. An extra dose will not benefit you. In case of accidental overdose, visit your doctor. Overdose may cause atrial fibrillation (irregular heartbeat).

Missed a Dose

As soon as you recall missing a dose, please take it. If the time to take another dose of your medicine is near, skip the missed dose. Do not double the dose.

Frequently Asked Questions (FAQs)

There is limited data on use in this population, kindly consult your doctor before use.

The medicine should be taken consistently, for example: if you take medicine before eating, kindly continue the same practice for the rest of the therapy and avoid taking the medicine after eating food and vice versa.

Sirolimus tablets may contain lactose and sucrose. In case of intolerance to these sugars, kindly consult your doctor before use of this medicine.

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