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Molecule Description

Sertraline is a prescription medication used for the treatment of depression and anxiety. It belongs to a group of medicines called SSRIs (Selective Serotonin Reuptake Inhibitors).

Uses of Sertraline

  • Treatment and prevention of major depressive episodes
  • Anxiety disorder
  • A mental disorder in which a person fails to recover after watching or experiencing a terrible incident or accident (Post Traumatic Stress Disorder or PTSD)
  • Panic disorder, with or without fear of places and situations that may cause panic (agoraphobia)
  • A behavioral disorder in which a person repeatedly does the same thing (Obsessive Compulsive Disorder or OCD) (in adults and children and adolescents aged 6-17 years old)

Contraindications of Sertraline

When should one not use Sertraline

  • Allergic reactions or intolerance to Sertraline or any of the substances used in the tablet
  • A class of antidepressants called irreversible MAO (Monoamine Oxidase) inhibitors (Phenelzine, Selegiline, Moclobemide, Toloxatone, Brofaromine, Isocarboxazid)
  • Pimozide (an antipsychotic)

Side effects of Sertraline

Common side effects of this drug are:

  • Sleep disorders (sleeplessness or insomnia, excessive sleep)
  • Dizziness, headache
  • Dry mouth
  • Abdominal pain, upset stomach, diarrhea & constipation
  • Tremors, shaking muscular movements, numbness, and tingling
  • Ejaculation failure (failure to release sperm), menstrual irregularities in females
  • Increased sweating
  • Severe anxiety
  • Decreased appetite
  • Suicidal thoughts and behavior have been reported when using
  • Sertraline or immediately after discontinuation

Precautions and Warnings of Sertraline


Can I take Sertraline during pregnancy?
Sertraline is not recommended in pregnancy unless there is no other alternative as it may be harmful for the unborn baby. Consult your doctor if you are pregnant or might be pregnant.

Breast Feeding

Can I take Sertraline while breastfeeding?
Sertraline is secreted into breast milk but not known to cause any harmful effects. But it is advised to use Sertraline while breastfeeding if your doctor feels it is necessary and there are no other alternatives.


Can I drive if I have consumed Sertraline?
Sertraline is a medicine that acts on the brain and may cause side effects like dizziness, headache, vision problems and altered mental states (though not in all cases). It is recommended to be extremely cautious while driving and it is advised not to drive for long distances.


Can I consume alcohol with Sertraline?
Do not drink alcohol while on the medication of Sertraline as alcohol also causes a high level of Sertraline and the combined effect may be harmful.

Other General Warnings

Talk to your doctor if
  • You have seizures (fits)
  • You have blurred vision, tunnel vision, eye pain or swelling, headache, confusion, memory problems, severe weakness, feeling unsteady (symptoms of low levels of sodium in the body)
  • You have racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative
  • You have diabetes or liver problems, bleeding disorders, serotonin syndrome (severe anxiety (agitation), tremors and persistent fever (hyperthermia)), neuroleptic malignant syndrome (a life threatening condition with high fever, increased breathing and heart rate and altered mental status in response to certain antipsychotic medicines)
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Mode of Action of Sertraline

How Does It Work?

Serotonin is a natural substance produced in the body which acts as a messenger to transmit signals in the brain (neurotransmitter). It is known as ‘happy chemical’ as it promotes positive thoughts and happy feelings. Sertraline prolongs the action of serotonin and thereby reduces depression.
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Interactions of Sertraline

Interactions with other medicines

  • Medicines that may (prolong QT interval) cause irregular heartbeats and heart attack (Quinidine, Disopyramide, Procainamide, Propafenone, Amiodarone, Sotalol)
  • Medicines that increase the risk of bleeding (Warfarin, pain killers, Aspirin)
  • Muscle relaxing medicines (Mivacurium)
  • Medicines used to treat migraine (Triptans – Almotriptan, Sumatriptan, Naratriptan, Zolmitriptan)
  • Medicines to treat heart disease and high blood pressure (Digoxin, Atenolol, Verapamil, Diltiazem, Flecainide, Propafenone)
  • Medicines used to reduce stomach acid (Cimetidine, Omeprazole, Lansoprazole)
  • Anti-infectious medicines (Rifampicin, Clarithromycin, Erythromycin)
  • Antifungal medications (Ketoconazole, Itraconazole, Posaconazole, etc.)
  • Medicines to treat HIV/ AIDS (Ritonavir)
  • A class of antidepressants called MAO (Monoamine Oxidase) inhibitors (Phenelzine, Selegiline, Moclobemide, Toloxatone, Isocarboxazid)
  • Other medicines which depress brain function (Carbamazepine, Haloperidol, Phenytoin)
  • Linezolid
  • Pimozide (an antipsychotic)

Interactions with food items

Sertraline does not interact with food and can be taken before or after meals.

Dietary Restrictions of Sertraline

Sertraline must not be taken with grapefruit juice. It may increase the level of Sertraline in your body.

Dosage of Sertraline


  • Being sick (vomiting)
  • Tremor
  • Feeling sleepy
  • Dizziness
  • Fast heart rate
  • Seizures

Missed a Dose

If you forget to take a dose, do not take the missed dose. Just take the subsequent dosage at the right time.

Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Is there anything else I must know about Sertraline?

  • Sertraline is one of the better efficacious and safer medicines compared to other antidepressants
  • Most of the side effects occur within the first two weeks of starting the treatment and are less frequent and less severe compared to other medicines used to treat depression
  • Sertraline is associated with restlessness (akathisia), where the patient is unable to sit or stand still and has a desire to move around. This is often seen in the first few weeks and there is no cause for concern. Inform your doctor. The symptoms usually subside in a few days or your dose may need to be adjusted
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  • Self-medication or self-adjusting the dosage of Sertraline is strictly not advised

Q: What is Serotonin syndrome?

A: When Sertraline is used with certain other medicines (e.g. irreversible Monoamine Oxidase (MAO) inhibitors like Selegiline, Moclobemide, etc.), it may cause levels of serotonin to increase leading to a condition called serotonin syndrome. Severe anxiety (agitation), tremors and high-temperature condition (hyperthermia).
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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