Ribociclib

Uses	Metastatic breast cancer
Therapy	Anti-Neoplastic
Side Effects	Nausea, vomiting, shortness of breath, sore mouth, loss of appetite, diarrhoea, abdominal pain, rash, hair loss, headache and dizziness, risk of infections

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Molecule Description

Ribociclib is an anticancer medicine. It is a CDK (cyclin-dependent kinase) inhibitor. Ribociclib works by inhibiting the growth and spread of cancer cells. It is usually prescribed for the treatment of metastatic breast cancer. It is a prescription medicine and must be taken as advised by the doctor. Inform your doctor if you have any preexisting medical conditions before using this medication. Inform your doctor about all medications you are taking. Also, inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Uses

Metastatic breast cancer

Contraindications

When should one not use Ribociclib

Allergy to the active ingredient or any of the excipients in Ribociclib
Pregnancy
Breastfeeding

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Shortness of breath
Sore mouth
Loss of appetite
Diarrhoea
Abdominal pain
Rash
Hair loss
Headache & dizziness
Risk of infections

Precautions and Warnings

Pregnancy

Ribociclib is not recommended during pregnancy and in women of childbearing potential not using contraception.

Breast Feeding

Patients receiving Ribociclib should not breastfeed.

Driving

Ribociclib may have a minor impact on your ability to drive and operate machinery. Patients should exercise caution when driving or operating machinery if they experience fatigue, dizziness, or vertigo while taking Ribociclib.

Alcohol

No information is available on the interactions between Ribociclib and alcohol.

Other General Warnings

Talk to your doctor if

You are taking any other medications
You are pregnant or plan to become pregnant
You get any side effects or allergic reactions after taking this medicine
You have any infection
Do not breastfeed during treatment and at least 3 weeks after the last dose
Use contraception during the treatment and at least 3 weeks after the last dose
Before beginning treatment with Ribociclib, liver function tests should be performed. After starting treatment, liver function should be monitored.
Ribociclib should not be used in patients who already have or are at high risk of developing QTc prolongation.
The use of Ribociclib may result in an increase in blood creatinine. If blood creatinine levels rise while on treatment, a further evaluation of kidney health is recommended to rule out kidney problems.

Mode of Action

How Does It Work?

Ribociclib is a CDK inhibitor (cyclin-dependent kinase inhibitor) and selectively inhibits CDK4 and CDK6. The CDK4 and CDK6 proteins are found both in healthy cells as well as in cancer cells. They control the multiplication and division of cells. In breast cancer, these proteins can become overactive and cause the cells to grow and divide uncontrollably. CDK4/6 inhibitors like ribociclib interrupt these proteins to slow or even stop the cancer cells from growing abnormally.

Dosage

Overdose

In the event of an overdose, report to your doctor immediately.

Missed a Dose

Report to your doctor immediately. Do not take extra doses to compensate for missed doses.

Frequently Asked Questions (FAQs)

Nausea, vomiting, shortness of breath, sore mouth, loss of appetite, diarrhoea, abdominal pain, rash, hair loss, headache, and dizziness are some of the side effects of Ribociclib. Inform your doctor if any side effects bother you or do not go away on their own.

Patients should take Ribociclib at the same time every day, preferably in the morning. If the patient vomits after taking the dose or misses a dose, no additional doses should be taken that day.