Ranolazine

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Molecule Description

Ranolazine is an anti-anginal medication.

Uses

Ranolazine is used for angina pectoris, a condition characterized by severe chest pain.

Contraindications

When should one not use Ranolazine

If you are allergic to ranolazine If you have severe kidney problems or liver problems If you are using certain medicines to treat bacterial infections (clarithromycin, telithromycin), HIV medicines, fungal infections (itraconazole, ketoconazole, voriconazol, posaconazole), depression (nefazodone) or heart rhythm disorders (e.g. quinidine, dofetilide, or sotalol)

Side effects

Common side effects of this drug are:

Nausea, vomiting, stomach pain
Constipation
Mild dizziness, spinning sensation
Headache
Swelling in your hands, ankles, or feet
Slow, fast, or pounding heartbeats
tremors or shaking
Blood found to be present in your urine; urinating less than usual or not at all
Shortness of breath
Skin rash, bruising, severe tingling, numbness, pain, and muscle weakness
Ringing in your ears
Anxiety, difficulty sleeping, confusional state
Blurred vision, visual disturbance

Precautions and Warnings

Pregnancy

It is not established whether ranolazine will harm an unborn baby. This medicine should not be taken in pregnancy unless prescribed by your doctor

Breast Feeding

It is not established whether ranolazine passes into breast milk or if it could harm a nursing baby. Inform your doctor if you are breast-feeding a baby.

Driving

Ranolazine can cause dizziness, blurring of vision, confusion. Caution is advised while driving.

Alcohol

Ranolazine may interact with alcohol and increase side effects like light-headedness and dizziness.

Other General Warnings

Talk to your doctor if

Have liver or kidney problems
Have ever had an abnormal electrocardiogram (ECG)
Have heart failure

Mode of Action

How Does It Work?

Ranolazine works by reducing the tension in the heart wall, thus reducing the oxygen requirement of the heart muscles .

Interactions

Interactions with other medicines

Ranolazine may interact with other medicines like antibiotics such as azithromycin, moxifloxacin, levofloxacin, and clarithromycin; antifungals such as ketoconazole and itraconazole; and with rifampin, phenobarbital, and anti-depressant medicines, antidiabetics like metformin, lipid-lowering medicines like statins (simvastatin, lovastatin, atorvastatin) these medicines can be caused muscle pain, medicines used in organ transplant ( tacrolimus, ciclosporin).

Interactions with food items

You should not drink grapefruit juice when taking this medicine.

Dietary Restrictions

Avoid grapefruit juice

Dosage

Overdose

High doses of ranolazine produce dizziness, nausea, and vomiting. Severe tremor, incoordination, difficulty speaking, and seeing things that don’t exist(hallucinations) have also been reported in cases of overdose with ranolazine. Seek emergency medical attention immediately.

Missed a Dose

If you forget to take a dose, take it as soon as you remember unless it is nearly time (less than 6 hours) to take your next dose. Do not take an extra or double dose to compensate for a forgotten dose.

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