Polmacoxib
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Molecule Summary
| Uses | Osteoarthritis |
| Therapy | Drugs For Osteoarthritis |
| Side Effects | Nausea, Headache, Upset stomach |
Medicines
available
19k pincodes
Molecule Description
Polmacoxib is a medicine that works as a pain reliever and reduces inflammation. It targets two specific processes in the body: it tries to lower pain and inflammation by blocking the enzyme COX-2, and it also affects carbonic anhydrase (CA). By addressing both areas, it aims to minimise heart-related side effects while also being beneficial in reducing arthritis pain.
Take as directed by your doctor. It is taken orally and may be taken with or without food, as a whole, with sufficient amount of water. Side effects may include nausea, headache and upset stomach.
Uses
- Polmacoxib is used in the treatment of osteoarthritis affecting the knee and hip joints.
Contraindications
When should one not use Polmacoxib
- If you are allergic to polmacoxib, ibuprofen, aspirin, any other medicines of the NSAID group or any other ingredients of Polmacoxib.
- If you have experienced bleeding from the stomach, have stomach ulcers or bleeding from the stomach or gut.
- If you have an increased bleeding tendency.
- If you suffer from severe heart, kidney or liver failure.
- If you are pregnant (last 3 months).
Side effects
Common side effects of this drug are:
- Nausea
- Headache
- Upset stomach
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have stomach-related problems like bleeding from the stomach and ulcers (ulcerative colitis, Crohn's disease) or bleeding disorders.
- You have a history of allergic problems, asthma, etc.
- You have heart-related problems and diabetes.
- You have a serious disease of the kidney or liver.
- You suffer from autoimmune disorders like systemic lupus erythematosus (risk of aseptic meningitis) and mixed connective tissue disorders.
- You are pregnant or are planning to get pregnant.
- Use Polmacoxib with caution in the case of children and the elderly.
Mode of Action
How Does It Work?
NSAIDs help with osteoarthritis pain and stiffness, but their side effects limit long-term use. Older NSAIDs (COX-1 blockers) can harm your stomach. Newer ones (COX-2 blockers) increase the risk of heart problems. A relatively safer alternative is Polmacoxib, a new oral NSAID. It works differently by targeting both COX-2 and carbonic anhydrase (CA). This distinctive method is expected to help relieve joint pain while notably reducing cardiovascular side effects.
Interactions
Interactions with other medicines
- Interaction with ketoconazole or erythromycin: When using Polmacoxib together with ketoconazole or erythromycin, it might be necessary to use a lower dose than usual.
- Interaction with ACE inhibitors or angiotensin II receptor blockers: Polmacoxib can lessen the effect of ACE inhibitors or angiotensin II receptor blockers, which are used to lower blood pressure.
- Interaction with diuretics: Some patients may find that Polmacoxib reduces the effectiveness of furosemide and thiazide diuretics, which help remove extra fluid from the body by affecting kidney function.
- Interaction with aspirin: Using Polmacoxib along with aspirin may lead to more stomach problems, like ulcers, compared to when Polmacoxib is used alone.
Dosage
Overdose
If you have taken too much of Polmacoxib, then contact your doctor or reach out to the nearest hospital immediately, as an overdose may result in nausea, vomiting, headache, drowsiness, blurred vision and dizziness.
Missed a Dose
If you have missed taking any dose of Polmacoxib, then take it as soon as you remember. If it's already time for the next dose, then skip the missed dose and follow your regular dosing schedule.
Frequently Asked Questions (FAQs)
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