Molecule Description

Omeprazole+Domperidone is a combination medicine. It is an anti-reflux medicine ...
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    Side effects
    Precautions and Warnings
    Mode of Action

Uses of Omeprazole+Domperidone

Omeprazole+Domperidone is used to treat gastrointestinal reflux disease (GERD), not responding to omeprazole alone.

Contraindications of Omeprazole+Domperidone

When should one not use Omeprazole+Domperidone

  • If you are allergic to omeprazole+domperidone
  • If you have problems with your heart, liver or kidney.
  • If you suffer from bleeding in the digestive system.
  • If you have problems relating to the bones such as osteoporosis and a fracture.
  • If you have any tumour of the pituitary gland (Prolactin pituitary tumours).
  • If you have low magnesium levels in your blood.

Side effects of Omeprazole+Domperidone

Common side effects of this drug are:

  • Headache
  • Dizziness
  • Stomach pain
  • Diarrhoea
  • Dry mouth
  • Injection site reactions

Precautions and Warnings of Omeprazole+Domperidone



Can I take omeprazole+domperidone during pregnancy?
It is not advised to take omeprazole+domperidone during pregnancy until it is considered essential by the doctor and potential risks justify the benefits.

Breast Feeding

Can I take omeprazole+domperidone while breastfeeding?
Omeprazole+Domperidone passes in the breastmilk in a small amount. Your doctor may prescribe you this medicine while you are breastfeeding, only if it is necessary. Inform your doctor if you are a nursing mother.


Can I drive if I have taken omeprazole+domperidone?
Omeprazole+Domperidone may cause dizziness, thus you need to be cautious while driving.


Can I consume alcohol with omeprazole+domperidone?
Avoid consuming alcohol with omeprazole+domperidone, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if
  • You suffer from any heart problems such as heart failure, heart rhythm problems, electrolyte imbalance
  • You have problems with your liver or kidney.
  • You have a stomach tumour/cancer
  • You are taking medicines to treat HIV.
  • You have a history of fractures or have osteoporosis or are taking steroids.
  • You develop watery/black stools or fever after taking omeprazole+domperidone.
  • You get rashes on your skin on exposure to sun after taking this medicine.
  • Your blood magnesium levels may drop, if you are taking this medicine for more than three months. Your doctor may perform regular tests.
  • Taking omeprazole+domperidone for more than one year may increase the chances of developing bone fractures.

Mode of Action of Omeprazole+Domperidone

How Does It Work?

  • A pump called the proton pump in the stomach is responsible for the secretion of stomach acids. Omeprazole works by binding to this proton pump in stomach cells, thus blocking acid secretion.
  • Domperidone works by increasing the motility of the stomach and intestines so that acid does not reflux back into the food pipe.

Interactions of Omeprazole+Domperidone

Interactions with other medicines

  • Some medicines can affect the way omeprazole+domperidone works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time. Tell your doctor about all the medicines...
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  • Especially if you are taking medicine to treat your heart problems, psychiatric illnesses, HIV infection, fungal or bacterial infections or are taking blood thinners or medicines like methotrexate, ta...
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  • Medicines like clopidogrel, atazanavir, nelfinavir, erythromycin, posaconazole, ketoconazole, itraconazole should not be used along with this combination.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Is omeprazole+domperidone an antibiotic?

A: No, omeprazole+domperidone is not an antibiotic, it is an anti-reflux medicine.

Q: In which all dosage forms is omeprazole+domperidone available?

A: Omeprazole+Domperidone is available in the form of tablet, capsule, injection.
Last Updated on: 19 Nov 2021 | 10:55 AM (IST)

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