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Molecule Description

Norethisterone is used for the treatment of menstrual and gynaecological disord

ers. It is a synthetic form of the female sex hormone progesterone. It imitates the actions of the natural hormone progesterone, normalizing the menstrual cycle. Inform your doctor about your complete medical and medication history before initiating treatment with this medicine. Norethisterone is available in the form of tablet, solution for injection, granule.


Uses of Norethisterone

Norethisterone is used for the treatment of menstrual and gynaecological disorders such as the absence of menstrual periods, delayed periods, abnormal bleeding and hormone replacement therapy.

Contraindications of Norethisterone

When should one not use Norethisterone

  • If you are allergic to norethisterone
  • If you have a history of heart disorders like chest pain (angina), heart attack or stroke.
  • If you have active or have a history of liver-related diseases such as jaundice.
  • If you have blood clotting disorders such as thrombophlebitis and thromboembolism.
  • If you have a history of jaundice or skin allergies such as pruritus during pregnancy.
  • If you have disorders of lipid metabolism or abnormal cholesterol levels.
  • If you often experience vaginal bleeding and it is not being diagnosed yet.
  • If you have a history of breast or vaginal cancer.

Side effects of Norethisterone

Common side effects of this drug are:

  • Headache
  • Nausea
  • Spotting
  • Bleeding
  • Swelling
  • Injection site reactions

Precautions and Warnings of Norethisterone



Can I take norethisterone during pregnancy?
Norethisterone should be avoided during pregnancy. Consult your doctor if you become pregnant during the treatment.

Breast Feeding

Can I take norethisterone while breastfeeding?
Norethisterone should not be used while breastfeeding. Consult a doctor before using it.


Can I drive if I have taken/used norethisterone?
Norethisterone is not known to affect the ability to drive or use machinery. In case of side effects like dizziness, avoid driving or using machines.


Can I consume alcohol with norethisterone?
No known interaction is available with alcohol along with norethisterone.

Other General Warnings

Talk to your doctor if
  • You suffer from heart disease, disease related to blood vessels or high blood pressure.
  • You have a history of gallstones, liver disease, kidney disease, impaired sugar tolerance or asthma.
  • You suffer from muscle twitch (tetany) or diabetes.
  • You may develop a cancerous or non-cancerous liver tumour on the long term use of the medicine.
  • You have a history of a disease in which the immune system eats away the protective covering of nerves (multiple sclerosis).
  • You develop vision impairment, inform the doctor.
  • You are an older person or have a habit of smoking and high cholesterol.
  • You have a history of porphyria (a rare inherited blood disease) and otosclerosis (an inherited form of deafness that gets worse during pregnancy).
  • You have a history of varicose veins (enlarged veins and most commonly appearing in the legs and feet).
  • You develop a migraine, headache, mood changes, rise in blood pressure or jaundice, a doctor must stop the medicine.
  • You are undergoing surgery
  • You need to be kept under observation during the treatment to check clots in blood vessels.

Mode of Action of Norethisterone

How Does It Work?

It acts similarly to the naturally present progesterone that works in normal conditions and helps in regulating the normal functions of the uterus.

Interactions of Norethisterone

Interactions with other medicines

  • Some medicines affect the way norethisterone works or the medicine itself reduce the effectiveness of other medicines taken at the same time.
  • Inform the doctor regarding the medicines, supplements or herbals you take or might take to avoid possible interaction.
  • Especially if you are taking medicines to treat high blood pressure, heart failure, high/abnormal cholesterol levels, blood thinners, anti-infectives, anti-asthmatics, pain killers, immunomodulatory m...
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  • Norethisterone must not be taken along with medicines containing steroids like prednisone, prednisolone.

Content Details


Dr. Mansi Savla

B. Pharm, PharmD


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What is norethisterone used for?

A: Norethisterone is used for the treatment of menstrual and gynaecological disorders such as the absence of menstrual periods, delayed periods, abnormal bleeding and for hormone replacement therapy.

Q: In which all dosage form is norethisterone available?

A: Norethisterone is available in the form of tablet, solution for injection, granule.
Last Updated on: 22 Dec 2021 | 11:37 AM (IST)
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