Nintedanib

Uses	Idiopathic pulmonary fibrosis (IPF), Non-small cell lung cancer (NSCLC)
Therapy	Anti-Neoplastic, Drugs For Idiopathic Pulmonary Fibrosis
Side Effects	Diarrhoea, nausea, vomiting, headache, stomach pain

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Molecule Description

Nintedanib is used to treat a rare lung disease known as Idiopathic Pulmonary Fibrosis (IPF). It is also prescribed for specific forms of lung cancer in combination with another anticancer medication called docetaxel. Nintedanib works by reducing the activity of certain enzymes called tyrosine kinases that contribute to fibrosis (scarring), thereby helping to slow the scarring of the lungs. For optimal results, take Nintedanib with food at the same time every day. Your doctor will determine the appropriate dosage and schedule for you, which may be adjusted as necessary. Follow your doctor's instructions carefully, as improper use or an overdose can lead to serious side effects. Do not discontinue this medication without consulting your doctor, even if it takes weeks or months to notice any benefits. A very common side effect of this medicine is diarrhoea. It is essential to drink plenty of fluids and consult your doctor if symptoms persist. Other common side effects may include nausea, stomach pain, vomiting, weight loss, high blood pressure, and headaches. Your doctor may also order blood tests to monitor your liver function. Before starting Nintedanib, inform your doctor if you have any bleeding problems or issues with your liver or kidneys. Additionally, please inform your healthcare team about all other medications you are taking, as many can interact with this medication. Nintedanib is not recommended for use during pregnancy or while breastfeeding. To prevent pregnancy, both male and female patients are advised to use effective contraception during treatment.

Uses

Nintedanib is used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer.

Contraindications

When should one not use Nintedanib

If you are allergic to nintedanib or any other ingredients of this medicine.
If you are allergic to peanuts or soya.
This medicine should never be used during pregnancy.

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Diarrhoea
Headache
Stomach pain
Decreased appetite

Precautions and Warnings

Pregnancy

Nintedanib should not be taken by a pregnant woman as it can harm the unborn baby. Consult your doctor before using it during pregnancy. Women should not become pregnant while taking this medicine and use highly effective birth control during treatment and for at least 3 months after treatment.

Breast Feeding

It is not known if Nintedanib passes into the breastmilk. Consult your doctor before using it while breastfeeding.

Driving

Nintedanib has a minor influence on the ability to drive and use machines. Be cautious if you experience any symptoms that affect your ability to stay alert.

Alcohol

There is limited information available on the interaction of Nintedanib with alcohol. Consult your doctor if you have a regular habit of drinking.

Other General Warnings

Talk to your doctor if

You have liver problems, heart problems or a family history of bleeding problems.
You have a history of a blood-clotting disorder, or you smoke.
You have had recent surgery in your stomach (abdominal) area.
You are pregnant, planning a baby, or breastfeeding.

Mode of Action

How Does It Work?

Nintedanib works by inhibiting the action of tyrosine kinases, a group of enzymes involved in the development of lung fibrosis. These enzymes are also involved in the process of forming new blood vessels in tumour cells.
By inhibiting these enzymes, this medicine can help slow down scarring and the progression of cancer.

Interactions

Interactions with other medicines

Certain medicines can affect the way Nintedanib works, or this medicine itself can interact with the action of other medicines taken concurrently.
Therefore, it is essential to inform your doctor about all the medications, supplements, or herbal products you are currently taking or may take in the future.
In particular, if you are taking a blood thinner, additional monitoring is required as this medicine can increase the risk of bleeding.
Concomitant administration of anti-infective medicines such as erythromycin and rifampicin; medicines for brain-related disorders such as phenytoin, carbamazepine and St. John's wort should be avoided.

Interactions with food items

Nintedanib should be taken with meals.

Dosage

Overdose

Seek immediate medical help in case of an overdose. Do not exceed the recommended daily dose of this medicine.

Missed a Dose

If you have missed taking a dose of Nintedanib, take your next dose at your regular time. Do not take the missed dose.

Frequently Asked Questions (FAQs)

No, Nintedanib should be taken with food and a sufficient amount of water. Do not crush or chew the medicine.

You may experience nausea, vomiting, stomach pain, headache, and other side effects after taking this medicine. But not everybody taking this medicine experiences these side effects.

Idiopathic Pulmonary Fibrosis is a lung condition in which the tissue of the lungs becomes scarred, which makes the lungs unable to transport oxygen into the bloodstream effectively. It may be caused by abnormal tissue repair following tissue damage.

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