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Molecule Description

Milnacipran is used in the treatment of chronic pain caused by Fibromyalgia although it works as an antidepressant.

Uses of Milnacipran

  • Chronic pain caused by Fibromyalgia (that affects the muscles, tendons, ligaments and supporting tissues)
  • Depression

Contraindications of Milnacipran

When should one not use Milnacipran

  • It is advisable to avoid taking Milnacipran in:
  • If you are allergic to this medicine
  • Child below 18 yrs of age
  • Kidney disease
  • Heart disease, high BP
  • Blood cell disorder e.g. sickle cell or haemophilia
  • Glaucoma
  • Low sodium levels in the body
  • Problems in urination
  • Bipolar disorder
  • Liver disorder
  • Convulsions or epilepsy

Side effects of Milnacipran

Common side effects of this drug are:

  • Nausea, vomiting
  • Dry mouth
  • Constipation
  • Increased sweating
  • Headache
  • Dizziness
  • Insomnia
  • High blood pressure
  • Serious side effects:
  • Allergic symptoms - itching, hives, rash, swelling of lips, face, etc.
  • Liver complaints – stomach pain, nausea, vomiting, jaundice, dark urine
  • Blurred vision, tunnel vision
  • Convulsion
  • Easy bruising, bleeding
  • Manic episodes – increased energy, extreme happiness, talkative etc.
  • High serotonin signs - hallucination, fever, agitation, nausea, vomiting, diarrhea, fainting, etc.
  • Low sodium signs – headache, confusion, slurred speech, loss of coordination, severe weakness, etc.
  • High BP – severe headache, chest pain, breathlessness, irregular heartbeats, nosebleed, etc.

Precautions and Warnings of Milnacipran


Can I take Milnacipran during pregnancy?
It is advisable to avoid taking Milnacipran during pregnancy. It may affect the unborn baby.

Breast Feeding

Can I take Milnacipran while breastfeeding?
It is not recommended in breastfeeding. It is still not known if it passes into breast milk. Doctor's consultation is advised.


Can I drive if I have consumed Milnacipran?
It may impair your thinking or reactions and this in turn, may affect your ability to drive. Be cautious while driving if you are on this medication.


Can I consume alcohol with Milnacipran?
Milnacipran may cause excessive drowsiness and calmness with alcohol. It may worsen existing liver damage. It is advised to avoid excess intake of alcohol with this medicine.

Other General Warnings

Talk to your doctor if
  • You notice abrupt mood changes or develop suicidal thoughts
  • You have any liver, kidney or heart problems
  • You have any psychiatric conditions or you're on a medication for that

Mode of Action of Milnacipran

How Does It Work?

This medicine is Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). It works by helping to restore the balance of certain natural substances present in the brain (neurotransmitters), thereby reducing the pain and assisting in the management of Fibromyalgia. It is also used in the management of depression.
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Interactions of Milnacipran

Interactions with other medicines

  • Narcotic pain medicine, sleeping pills, muscle relaxants, medicine for anxiety, depression, fits, etc.
  • Certain medicine, when taken along with Milnacipran, can cause Serotonin syndrome – e.g., Medicine for Parkinson’s disease, migraine, ADHD, etc.
  • Blood thinners e.g., Warfarin

Interactions with food items

No adequate information.

Dosage of Milnacipran


  • The symptoms of overdose can be – slow heart rate, weak pulse, fainting, slow breathing, etc.
  • Seek medical emergency help in case of overdose

Missed a Dose

If you miss a dose, take medicine when you remember the missed dose. If it is almost time for your next dose, don’t take the missed dose and go back to the regular dosing schedule. Do not take a double dose.
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Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Milnacipran?

  • Inform the doctor about your detailed medical & surgical history
  • Inform your physician if you have any of the following conditions -
  • Liver disease
  • Kidney disease
  • Heart disease, high BP
  • Blood cell disorder e.g. sickle cell or haemophilia
  • Glaucoma
  • Low sodium levels in the body
  • Problems in urination
  • If you drink alcohol
  • If you are taking blood thinners, e.g. warfarin
  • If you are pregnant, lactating or planning a pregnancy

Q: How is this medicine removed from the body?

A: About 58% of medicine is removed through urine.

Q: How long this medicine stays in the body after taking it?

A: Half-life of this medicine is around 8-10 hours; hence, it can stay up to 16-20 hours in the body.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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