Medroxyprogesterone

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Molecule Description

Medroxyprogesterone is a form of progesterone (a female hormone) that helps regulate ovulation and menstrual cycles.

Uses

Absent or irregular periods
Heavy periods (abnormal bleeding from uterus)
Mild to moderate endometriosis
Used as contraceptive
Uterine cancers (recurrent or metastatic)

Contraindications

When should one not use Medroxyprogesterone

Ongoing pregnancy
Liver disease
Hormone-related tumors e.g. breast cancer, ovarian cancer
History of stroke
Known anaphylactic reaction or angioedema
Undiagnosed vaginal bleeding

Side effects

Common side effects of this drug are:

Headache, dizziness
Feeling nervous or depressed
Spotting or breakthrough bleeding
Changes in your menstrual periods
Breast discharge
Bruising or swelling of your veins
Sleep disturbances
Itching, rash, acne, abnormal hair growth, hair fall
Stomach discomfort, bloating, nausea
Weight gain
Itching, hives, rash; yellowing of the skin or eyes
Vertigo or dizziness
A breast lump
Sleep problems
Dizziness
Mood changes
Fever
Jaundice
Swelling in your hands, feet
Chest pain, nausea, sweating
Signs of a stroke
Blood clot sign in your leg (Deep vein thrombosis (DVT))

Precautions and Warnings

Pregnancy

This medicine should not be used during pregnancy because it may be harmful for unborn baby.

Breast Feeding

Avoided in breastfeeding women as this medicine passes into breast milk.

Driving

This drug may lead to cause dizziness or drowsiness. Do not drive until you feel well.

Alcohol

Alcohol may lead to cause dizziness or drowsiness. Consult with your doctor.

Other General Warnings

Talk to your doctor if

Do not smoke. Smoking combined with this medicine may lead to increase risk factors like strokes, blood clots, high blood pressure and sometimes heart attacks.

Mode of Action

How Does It Work?

Medroxyprogesterone corrects the hormonal imbalance thereby regulating ovulation and menstrual disturbances.

Interactions

Interactions with other medicines

Aminoglutethimide, sometimes used in Cushing’s syndrome
Medicines for thinning the blood (e.g. Warfarin)
Medicines for treating convulsions (e.g. Phenobarbital, Phenytoin, and Carbamazepine)
Ritonavir and Nelfinavir sometimes used to treat HIV and AIDS
Medicines for treating infections (e.g. Nevirapine, Rifampicin, Rifabutin, Efavirenz)

Interactions with food items

This medicine is known to show certain side-effects like obesity, high cholesterol levels in blood and high blood pressure. You may be advised low fat, low salt diet while on this medication. Follow the instructions carefully.

Dosage

Overdose

Inform your doctor immediately in case of overdose.

Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Inform the doctor about your detailed medical & surgical historyInform your physician if you have any of the following conditions:Liver diseaseOngoing pregnancyHormone-related tumors – e.g. breast cancerHistory of strokeHigh BP, high cholesterolEpilepsy, asthma, migraineKidney disease, thyroid disease and diabetes

Medroxyprogesterone should be taken in the exact dose as advised by the physician. It is usually taken for few days in the month, from a particular day of the menstrual cycle. Follow the doctor’s instructions properly.

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