Linagliptin

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Molecule Description

Linagliptin is an oral antidiabetes medicine that helps to control high sugar levels in the body.

Uses

Type 2 diabetes

Contraindications

When should one not use Linagliptin

This medicine is not to be used if you are allergic to it.

Side effects

Common side effects of this drug are:

Severe pain in the stomach or lower back with nausea, vomiting, swelling pancreas (pancreatitis)
Swelling hip, face, tongue, difficulty breathing
Low blood sugar, confusion, mood change (hypoglycaemia)
Weight gain
Level of lipase in the blood increased
Inflamed nose or throat (nasopharyngitis)
Cough

Precautions and Warnings

Pregnancy

It is unknown if Linagliptin is harmful to the unborn child. Therefore, it is preferable to avoid using this medicine during pregnancy.

Breast Feeding

It is unknown if Linagliptin can pass into breast milk. Consult with the doctor. He/ she will tell you if you can continue this medicine or not during breastfeeding.

Driving

Linagliptin does not influence the ability to drive. But if this medicine is taken along with other diabetic medicine or injection, it may cause a fall in sugar level (hypoglycemia) and affect your ability to drive. Hence doctor consultation might be recommended before driving.

Alcohol

Do not drink alcohol as it can affect the control of sugar level.

Other General Warnings

Talk to your doctor if

You have or had disease of the pancreas
You have Type 1 Diabetes (body does not produce insulin)
You have any liver or kidney problems, stones in gallbladder
If you are taking any other anti-diabetic medicine like Glipizide

Mode of Action

How Does It Work?

Linagliptin inhibits the enzyme called Dipeptidyl Peptidase (DPP)-4, thereby prevents the breakdown of GLP-1 and GIP (Glucose-Dependant Insulinotropic Polypeptide). By preventing the failure, medicine prolongs the action of GLP-1 and GIP which stimulates the release of insulin from beta cells in the pancreas and it also decreases the release of glucagon from pancreatic alpha cells. These effects together increase the amount of insulin in a glucose-dependent manner and reduce the glucose production in the liver.

Interactions

Interactions with other medicines

Some medicines and Linagliptin interfere with each other and these include antibiotics like Rifampicin, medicine used to control fits or seizures like Phenytoin.

Interactions with food items

Consult with doctor if you have an allergy of any food.

Dietary Restrictions

No information is available on dietary restrictions while you are taking this medicine. Consult your doctor or pharmacist for further information.

Dosage

Overdose

An overdose of this medicine may cause life threatening hypoglycemia. Symptoms include hunger, weakness, sweating, tremors, slurred speech, irritability, trouble concentrating, fainting, rapid breathing, fast heartbeat. Consume some sugar/ sweet drink or eat a bar of chocolate and seek emergency medical attention immediately if you think you have overdosed on this medicine.

Missed a Dose

Take medicine as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and go back to the regular dosing schedule. Do not use extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Do not stop taking medicine without a consultation of your doctor. Your blood sugar levels may increase when you stop taking this medicine.

Half-life of Linagliptin is 12 hours; it can stay up to 24 hours in the body.

Consume some sugar/ sweet drink or eat a bar of chocolate so the sugar levels will increase. In case of severe conditions, seek emergency medical attention by approaching a nearby hospital.

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