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molecule

Leucovorin

Molecule Description

Leucovorin or Folinic Acid, as it is commonly known, is used to decrease the to

xicity of nerves (neurotoxic) and kidneys (nephrotoxic) post-chemotherapy. It can also be used to treat colorectal cancer.

uses

Uses of Leucovorin

Severe blood cell disorders (like thrombocytopenia, neutropenia, anemia) caused by certain medicines (Folic Acid antagonists such as Methotrexate, Trimethoprim, Pyrimethamine).
contraindications

Contraindications of Leucovorin

When should one not use Leucovorin

Allergy to anemia of the pernicious kind and any other form of Calcium Folinate.
sideEffects

Side effects of Leucovorin

Common side effects of this drug are:

  • Rash, itching/swelling (especially of the face, tongue, throat)
  • Severe dizziness, trouble breathing
precautionsAndWarnings

Precautions and Warnings of Leucovorin

pregnancy

Pregnancy

Q:
Can I take Leucovorin during pregnancy?
A:
This medicine is not recommended for pregnant women unless necessary, and it should be done in consultation with a doctor.
breastfeeding

Breast Feeding

Q:
Can I take Leucovorin while breastfeeding?
A:
Leucovorin is also not recommended for lactating and breastfeeding women. It is advised to consult a doctor before taking this medicine.
driving

Driving

Q:
Can I drive if I have consumed Leucovorin?
A:
There is no known information on this medicine interfering with activities that require focus and attention.
alcohol

Alcohol

Q:
Can I consume alcohol with Leucovorin?
A:
Alcohol is not recommended when taking this medicine. You should ask your doctor before consuming.
otherGeneralWarnings

Other General Warnings

Talk to your doctor if
Severe neurological complications and undergoing treatment with Fluorouracil.
modeOfAction

Mode of Action of Leucovorin

How Does It Work?

Leucovorin works by helping with the amino acid synthesis in the presence of dihydrofolate; this process allows regeneration of cells, thus helping revive cells.
interactions

Interactions of Leucovorin

Interactions with food items

No information is available on dietary restrictions while you are taking Leucovorin, consult your doctor or pharmacist for further details.
dosage

Dosage of Leucovorin

Overdose

Excess dosage of Leucovorin can result in the nullification of chemotherapeutic effects.

Missed a Dose

You should not take a double dose if you missed a dose.

Content Details

WRITTEN BY
doctor

Dr. Abhishek B L

MBBS, MD (Pharmacology)

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

^

Q: What is the difference between Folic Acid and Folinic Acid?

A: Folinic Acid is a vitamer of Folic Acid, which means that it shows a similar molecular structure and shows vitamin activity in any system that is vitamin deficient.

Q: Can it be given intrathecally (injection through the spine)?

A: No. Under no circumstances should this medicine be given intrathecally, which is administered through the spinal cord. Doing this can result in a severe and adverse effect.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.
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