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Isosorbide Mononitrate

Molecule Description

Isosorbide Mononitrate is used as an antianginal medicine for treating chest pa



Uses of Isosorbide Mononitrate

Heart related chest pain in ischemic heart disease (angina).

Contraindications of Isosorbide Mononitrate

When should one not use Isosorbide Mononitrate

  • Do not take if you are allergic to Isosorbide Mononitrate or any ingredient of this medicine
  • Do not take if you are under medication of:
  • Viagra (Sildenafil) used for male erectile dysfunction
  • Do not take if you have decreased blood supply to the brain

Side effects of Isosorbide Mononitrate

Common side effects of this drug are:

  • Severe headache initially but reduces as one continues the medicine
  • Flushing
  • Unsteadiness
  • Nausea and Vomiting
  • Pounding and rapid heartbeat
  • Drop in blood pressure
  • Elevation in level of Methemoglobin in blood, which has less affinity to oxygen, causing reduced oxygenation of tissues (Methemoglobinemia) - a rare, severe side effect

Precautions and Warnings of Isosorbide Mononitrate



Can I take Isosorbide Mononitrate during pregnancy?
If you are pregnant, consult your doctor before taking this medicine.

Breast Feeding

Can I take Isosorbide Mononitrate while breastfeeding?
It is probably not safe during breastfeeding, its better to consult with your doctor.


Can I drive if I have consumed Isosorbide Mononitrate?
It may give you a headache, blurred vision or make you feel dizzy or tired. If this happens to you, do not drive.


Can I consume alcohol with Isosorbide Mononitrate?
Do not drink alcohol. It could increase the effect of this medicine and lower your blood pressure too much. If this happens, you may feel dizzy or faint.

Other General Warnings

Talk to your doctor if
  • You have recently had a heart attack
  • You have an underactive thyroid gland
  • You have a head injury or bleeding of the brain
  • You have a poor diet or poor circulation
  • You have a very low body temperature

Mode of Action of Isosorbide Mononitrate

How Does It Work?

  • Angina is caused by constriction of the vessels supplying muscles of heart causing poor blood flow resulting in chest pain
  • This medicine dilates the blood vessels which eases the blood flow in them and decreases the load on heart
  • It also facilitates an increased amount of blood to flow to areas which need it

Interactions of Isosorbide Mononitrate

Interactions with other medicines

  • Medicines used to treat high blood pressure
  • Medicines used to treat heart failure
  • Medicines used in the treatment of erectile dysfunction like Sildenafil
  • Any medication which may cause a lowering of your blood pressure
  • Medicines such as Histamine, which is used to treat allergic reactions
  • Medicines used to treat migraines like Ergotamine

Interactions with food items

It is known to interact with food and the presence of food lessens its action. To be taken an hour after or half an hour before the meals. Low salt diet is preferred.

Dietary Restrictions of Isosorbide Mononitrate

No information is available on dietary restrictions while you are taking Isosorbide Mononitrate, consult your doctor or pharmacist for further details.

Dosage of Isosorbide Mononitrate


If you happen to take overdose, it may cause your blood pressure to fall too low, making you feel sick, faint and dizzy. Seek immediate medical attention.

Missed a Dose

Do not take a double dose if you have missed the dose; take the next dose as soon as you remember.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What special precautions should I follow while on this medication?

  • You must take this medicine precisely for the prescribed schedule as directed by your doctor. So make sure that you have understood what your dose is and how to space the intervals
  • Avoid Sildenafil or similar medicine while on nitrates. Sildenafil is used to treat sexual dysfunction. Complications of taking Sildenafil or other related compounds can be fatal
  • Keep the immediate-release tablets always with you
  • If you suffer from angina after exercise or exertion or any acute stressful event, you may need to take a pill immediately

Q: What should I discuss with my healthcare expert before I start taking this medicine?

A: You must give account of your medical and surgical history and all your ongoing medications. Discuss with your doctor if you are taking treatment for erectile dysfunction.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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