Ibrutinib

When should one not use Ibrutinib

• If you are allergic to ibrutinib or any other ingredient of Ibrutinib.
• If you are taking a herbal medicine called St. John's wort. If you are not sure what this medicine is, please confirm with your doctor.

Common side effects of this drug are:

• Diarrhoea
• Rash
• Nausea
• Fever
• Joint pain

Other General Warnings

• You have or had unusual bruising or bleeding or take any medicines or supplements that increase your risk of bleeding (warfarin).
• You have or had an irregular heartbeat, heart failure, or symptoms like weakness, dizziness, fainting, or swollen legs.
• You have liver or kidney problems.
• You have high blood pressure.
• You have recently had or are scheduled for surgery.
• You develop symptoms like trouble thinking, difficulty walking, vision disturbances, weakness in the limbs, headache, trouble speaking after taking this medicine.
• You experience pain in the upper left belly, pain below the left rib, pain at the tip of your left shoulder after stopping this medicine.
• You develop symptoms of an infection like fever, chills, body pain, tiredness, yellowing of the skin or eyes.

How Does It Work?

Interactions with other medicines

• Some medicines can affect the way Ibrutinib works or Ibrutinib itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
• The use of Ibrutinib along with anti-fungal medicines (ketoconazole, voriconazole), antibiotics (clarithromycin), anti-HIV medicines (indinavir, cobicistat), anti-depressants (nefazodone, fluvoxamine), medicines for nausea and vomiting (aprepitant), anti-cancer medicines (crizotinib), high blood pressure medicines (diltiazem), medicines for irregular heartbeat (amiodarone), grapefruit juice and Seville oranges may increase the levels of Ibrutinib in the body.
• The level of Ibrutinib may be decreased in the body when used together with anti-tuberculosis medicines (rifampicin), medicines for seizures/fits (phenytoin), herbal medicines containing St. John's wort, proton pump inhibitors (omeprazole).
• Care should be taken if you are taking medicines to treat heart failure (digoxin) or lower cholesterol (rosuvastatin).

Overdose

Missed a Dose