Glycopyrrolate

Uses	Chronic Obstructive Pulmonary Disease (Copd)
Therapy	Drugs For Chronic Obstructive Pulmonary Disease
Side Effects	Shortness of Breath and Urinary Tract Infections

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Molecule Description

Glycopyrrolate is an anticholinergic medicine which is used in conditions such as peptic ulcers, drooling in children with disorders that affect muscle movement and co-ordination, and as pre-anesthetic medication.

Uses

It is used for the treatment of peptic ulcers
It is also used to treat drooling in children with disorders that affect muscle movement and co-ordination
It can also be used as pre-anesthetic medication (Reduction of secretions in the body before surgery)
Frey syndrome

Contraindications

When should one not use Glycopyrrolate

If you have an allergy to this medicine.

Side effects

Common side effects of this drug are:

Nausea, vomiting
Constipation
Dry mouth
Dry skin
Dry eyes
Decreased sweating
Blurred vision
Photophobia
Flushing
Increased heartbeat
Itching, hives, rash
Dizziness
Excessive thirst
Difficulty in urination
Excessive crying in the child

Precautions and Warnings

Pregnancy

There are no adverse effects noted for using Glycopyrrolate during pregnancy. Still, you must inform your doctor as the safety of this medicine for use during pregnancy has not been established.

Breast Feeding

It is probably unsafe to take this medicine if you are breastfeeding or plan to breastfeed because the safety of this medicine for use during breastfeeding has not been established.

Driving

This medicine may cause dizziness or blurred your vision. If you are affected, do not drive.

Alcohol

It is unsafe to consume alcohol with this medicine. It may lead to cause you more dizzy or drowsy.

Other General Warnings

Talk to your doctor if

You have severe allergic reactions, including anaphylaxis (life threatening condition)
Inform your concerned doctor immediately if you have conditions like rash or itching to skin, abnormal voice changes, difficulty in breathing or swallowing, or in case any swelling to your hands, face, or mouth while taking this medicine
Before surgery regarding all the products you use (including prescription medicines, non-prescription medicines, and herbal products)

Mode of Action

How Does It Work?

Glycopyrrolate blocks the muscarinic acetylcholine receptor. It prevents the action of acetylcholine on the structures innervated by postganglionic cholinergic nerves and smooth muscles. Which, in return, reduces the salivary, tracheobronchial, and pharyngeal secretions. It also decreases the acidity of gastric secretions, blocks cardiac vagal inhibitory reflexes during intubation.

Interactions

Interactions with other medicines

Amantadine
Pramlintide
Atenolol
Metformin
Ketoconazole, Itraconazole
Digoxin
Antispasmodics (Clidinium, Dicyclomine, Propantheline)
Medicine used to treat Parkinson's disease (such as Levodopa, Benztropine, Trihexyphenidyl)
Medicine used to treat irregular heart rhythms (such as Disopyramide, Quinidine)
MAO inhibitors (Methylene blue, Moclobemide, Phenelzine, Isocarboxazid, Linezolid, Procarbazine, Rasagiline, Safinamide, Selegiline, Tranylcypromine)
Phenothiazines (such as Chlorpromazine)
Tricyclic antidepressants (such as Amitriptyline)

Interactions with food items

Take medicine on an empty stomach or at least 2-3 hours after meals as food reduces the effectiveness of this medicine. Drink plenty of liquids to prevent dehydration.

Dosage

Overdose

The symptoms of overdose can be - shallow breathing, feeling cold, muscle twitching, seizures, etc. These can be lethal and need immediate medical attention.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.

Frequently Asked Questions (FAQs)

Inform the doctor about your detailed medical & surgical historyInform your physician if you have any of the following conditions - Kidney diseaseHeart diseaseStomach disorder, reflux disease, or slow digestionThyroid disorderMyasthenia gravisHigh blood pressureVision problems or glaucomaBladder obstruction or other urination problemsBowel obstruction or severe constipationAlso, share information on all the ongoing medications that you may be taking

Glycopyrrolate should be taken in the exact dose as advised by the physicianThe liquid medicine should be measured in a measuring device and then consumedIt shouldn’t be taken on approximate measurementsShake the oral suspension before every useTake medicine on an empty stomach or at least 2-3 hours after mealsTake glycopyrrolate with a full glass of waterDrink plenty of liquids to prevent dehydration

This medicine blocks the acetylcholine receptors and decreases the secretions in mouth, eyes, and skin, leading to dryness of mouth, eyes, and skin.

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