Esmolol
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Molecule Summary
| Uses | Diabetic foot ulcers |
| Therapy | Anti-Hypertensive |
| Side Effects | Skin irritation, redness, itching or a burning sensation at the application site |
Medicines
available
19k pincodes
Molecule Description
Esmolol is a prescription topical treatment used to support the healing of diabetic foot ulcers, which are open wounds that can develop in people with diabetes due to poor blood circulation, nerve damage, and slow wound healing. These ulcers commonly appear on the feet and, if left untreated, may lead to serious complications. Esmolol is applied directly to the affected area to help improve healing when used along with proper wound care and medical supervision.
Esmolol is used to manage diabetic foot ulcers that do not show signs of infection. These ulcers may take a long time to heal because diabetes can affect blood flow and reduce the body's ability to repair damaged tissue. Using Esmolol as part of a comprehensive treatment plan may help improve healing and support wound closure.
Esmolol (as esmolol hydrochloride) helps stimulate the body's natural healing process in the affected area. When applied to the ulcer, it may support tissue repair, improve cellular activity involved in wound healing, and help the skin regenerate. This action can promote faster wound closure and help reduce the risk of complications when used together with proper wound care.
It should be used exactly as prescribed by your doctor. You should clean and dry the affected area before applying the medicine and follow proper dressing instructions if advised. While it is generally well tolerated, some people may experience mild skin irritation, redness, itching, or a burning sensation at the application site. These effects are usually temporary, but if they persist or worsen, consult your doctor.
Uses
Esmolol is used to promote healing in diabetic foot ulcers, open sores, or wounds commonly occurring in people with diabetes.
Contraindications
When should one not use Esmolol
- If you are allergic to any active ingredient of Esmolol
- If you have had a severe reaction to similar medicines, such as beta-blockers
- If the ulcer shows signs of infection, such as pus, severe redness, or swelling
- If you have severe circulation problems in the legs or feet
- If the wound has not been properly evaluated by a healthcare professional
Side effects
Common side effects of this drug are:
Some people may experience mild side effects while using Esmolol, such as skin irritation, redness, itching or a burning sensation at the application site.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a diabetic foot ulcer with signs of infection.
- You have severe peripheral vascular disease.
- You have a known allergy to esmolol or similar medicines.
- You have other serious foot complications related to diabetes.
- You have not received a proper wound assessment from a healthcare professional.
- You have applied more than the recommended amount.
Mode of Action
How Does It Work?
- Esmolol is used as esmolol hydrochloride.
- Esmolol Hydrochloride helps stimulate the body's natural wound-healing processes.
- It may improve cellular activity involved in tissue repair and skin regeneration.
- It supports the movement of cells that help rebuild damaged tissue.
- This helps promote faster healing and closure of diabetic foot ulcers when used with proper wound care.
Interactions
Interactions with other medicines
- Esmolol may interact with certain wound care medicines or treatments.
- Inform your doctor about all medicines, supplements, or herbal products you are taking.
- Let your doctor know if you are using other topical treatments on the same area.
- Your doctor will decide whether these treatments can be used together safely.
Dosage
Overdose
- Applying more than the recommended amount of Esmolol may increase the risk of skin irritation or discomfort.
- If you accidentally apply too much or notice unusual symptoms, consult your doctor immediately.
Missed a Dose
- If you forget to apply Esmolol, apply it as soon as you remember.
- If it is almost time for your next application, skip the missed one and continue with your regular schedule.
- Do not apply extra medicine to make up for the missed dose.
Frequently Asked Questions (FAQs)
Articles
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References:
- Kulkarni S, Deshpande P, Rastogi A. Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase and facilitating fibroblast migration. PubMed [Internet].[cited 6 June 2026].
- Rastogi A, Kulkarni SA, Agarwal S, et al. Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers: A Phase 3 Randomized Clinical Trial. PubMed [Internet]. [cited 6 June 2026].
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