Dutasteride

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Molecule Description

Dutasteride belongs to a group of medicine called 5-Alpha Reductase Inhibitors. It is used in men to treat noncancerous growth of the prostate gland which is caused by increased production of dihydrotestosterone (Benign Prostatic Hyperplasia).

Uses

It is used for the treatment of Symptomatic Benign Prostatic Hyperplasia (BPH) in men with an enlarged prostate.

Contraindications

When should one not use Dutasteride

Do not take Dutasteride if you are allergic to it or other 5-Alpha Reductase Inhibitor drugs (such as Finasteride), if you have a severe liver disease. This medicine is used in men patients only, women or children patients are prohibited from using this medicine.

Side effects

Common side effects of this drug are:

Allergic reaction like skin rash, itching, hives
Swelling of eye, legs
Unable to achieve or maintain an erection properly (impotence)
Decreased sex drive
Dizziness if this medicine is taken with Tamsulosin
Breast enlargement or tenderness (gynecomastia)222

Precautions and Warnings

Pregnancy

Dutasteride is not recommended in women. If in case pregnant women come in contact with leaked capsule of Dutasteride, immediately inform your physician as this medicine is absorbed through the skin and may affect the development of the unborn baby (if male). Watch out for this risk in the first 16 weeks of pregnancy Use contraceptives if your partner is pregnant

Breast Feeding

Dutasteride is not recommended to be used by women who are breastfeeding. This medicine is used for men only. Consult with a doctor for advice during breastfeeding.

Driving

Do not drive unless you feel well. This medicine may affect your ability to drive.

Alcohol

Be cautious and avoid the intake of alcohol with this medicine as alcohol may cause difficulty in urination.

Other General Warnings

Talk to your doctor if

You have any liver disease
Your partner is pregnant or may become pregnant

Mode of Action

How Does It Work?

When there is growth of the prostate gland, you may suffer from urine problems like frequent urination, difficulty in passing urine. It can also cause a decrease in the flow of urine and it increases the risk of acute urinary retention (completely block urine flow). Dutasteride decreases the production of dihydrotestosterone and helps to reduce the size of the prostate and reliefs from urinary problems.

Interactions

Interactions with other medicines

Some medicine may interact with Dutasteride e.g., Amiodarone, Amoxicillin, Ciprofloxacin, Cyclosporine, Diltiazem, Verapamil, Dasatinib, Fluconazole, Isoniazid, Itraconazole and Ketoconazole
Tell your doctor if you are taking Ritonavir because it may increase the risk of Dutasteride side effect

Interactions with food items

Do not eat grapefruit or drink grapefruit juice while taking this drug as this may cause too much concentration of Dutasteride in blood
Do not drink alcohol with Dutasteride because alcohol can dehydrate you and make urinating difficult

Dietary Restrictions

No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for further information.

Dosage

Overdose

If you think you have taken too much dose of Dutasteride medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

Take the missed dose as early as you remember. If the time for next sode is closer, skip the missed dose & do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Give a detailed account of your medical and surgical history to your doctor. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Do not donate your blood for at least 6 months after treatment with Dutasteride because this drug remains in the blood for 4 to 6 months. Use a condom during sexual intercourse. Dutasteride has been found in the semen of the men who were taking this medicine.

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