Diclofenac+Misoprostol

Uses	Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.
Therapy	Drugs For Rheumatoid Arthritis, Drugs For Osteoarthritis
Side Effects	Nausea, Vomiting, Diarrhoea, Dizziness, Headache, Drowsiness, Stomach pain.

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Molecule Description

Diclofenac+Misoprostol is a pain-relieving medicine. Diclofenac+Misoprostol is used to treat pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Diclofenac+Misoprostol is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat. Diclofenac+Misoprostol contains Diclofenac and Misoprostol as active ingredients.

Uses

Pain
Swelling and inflammation in conditions like rheumatoid arthritis, osteoarthritis and ankylosing spondylitis
Muscle and back pain, toothache, or pain in the ear and throat
Ulcers

Contraindications

When should one not use Diclofenac+Misoprostol

If you have a known allergy to diclofenac, other NSAIDs, misoprostol, or other prostaglandin medicines.
If you have an active ulcer in the stomach or intestines.
If you have diseases like Asthma, Heart failure, Liver disease, Kidney disease, Gastrointestinal bleeding etc.
Diclofenac+Misoprostol is also not recommended for relieving pain before, during, or after a coronary artery bypass graft procedure.

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Indigestion
Diarrhoea
Loss of appetite
Dizziness
Drowsiness
Stomach pain
Headache

Precautions and Warnings

Pregnancy

No, this medicine isn't recommended for use in pregnant women. Taking this medicine during pregnancy can cause the unborn baby serious kidney or heart problems.

Breast Feeding

No, this medicine is not recommended for use in breastfeeding women. Diclofenac+Misoprostol may pass in the lactating mother's breast milk and harm the baby.

Driving

Diclofenac+Misoprostol may cause dizziness and drowsiness. So if you face these symptoms, you should not drive.

Alcohol

No, it is not recommended to take Diclofenac+Misoprostol while consuming alcohol because it may increase the risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness etc.

Other General Warnings

Talk to your doctor if

You have a known history of kidney or liver disease.
You have a dehydration problem.
You have a known history of ulcerative colitis.
You see any adverse symptoms.

Mode of Action

How Does It Work?

Diclofenac+Misoprostol contains two active ingredients, Diclofenac and Misoprostol. Diclofenac works by reducing the formation of certain substances in the body that cause pain and swelling. Misoprostol is a prostaglandin analogue that reduces gastric acid secretion and protects the walls of the stomach. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation and pain.

Interactions

Interactions with other medicines

Methotrexate (an antimetabolite): this medicine can increase methotrexate toxicity in the body.
Ramipril (an ACE inhibitor, i.e. angiotensin-converting enzyme inhibitor): using it with this medicine can increase severe adverse effects in the body.
Ketorolac (an NSAID): using it with this medicine can increase the toxicity level in the body.
Adefovir (a nucleoside analogue): using it with this medicine can cause side effects in the body.
Dinoprostone (a prostaglandin): using it with this medicine can increase the severe toxicity level in the body.

Interactions with food items

You should take Diclofenac+Misoprostol during or after a meal to avoid stomach upset or irritation.

Dosage

Overdose

Misoprostol overdose can result in breathing difficulty, drowsiness, seizures, dizziness, and irregular heartbeat. You should consult the doctor or seek emergency medical treatment in case of overdose.

Missed a Dose

If you miss a dose, you should take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Frequently Asked Questions (FAQs)

No, it is not a habit-forming medicine. Most medicines don't come with a potential for addiction or abuse. Usually, the government categorises medicines that can be addictive as controlled substances. You should read the product package to ensure that the medicine does not belong to such a special category of medicines.

The heart can be affected by this medicine. Diclofenac+Misoprostol may increase the risk of heart problems like heart attack, primarily when used in high doses or for a prolonged duration, and in patients who are smokers, have high blood pressure, diabetes, or high cholesterol. Before taking Diclofenac+Misoprostol, you should inform the doctor if you have any of these conditions or have a history of heart problems.

No, Diclofenac+Misoprostol should not be taken in dengue because it may increase the risk of internal bleeding.

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